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Herpes Gene Therapy Achieves 90% Viral Reduction in Pre-Clinical Studies

Researchers at Fred Hutch Cancer Center have found in pre-clinical studies that an experimental gene therapy for genital and oral herpes removed 90% or more of the infection and suppressed how much virus can be released from an infected individual, which suggests that the therapy would also reduce the spread of the virus.

16 May 2024

Transcriptomic Analysis Reveals Age-Dependent Gene Expression Patterns in Mouse Sweat Glands

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, "Characterization of age-associated gene expression changes in mouse sweat glands."

15 May 2024

LSTM Scientists Discover Treatment for Tissue Damage by African Spitting Cobra Venom

Scientists at Liverpool School of Tropical Medicine (LSTM) have discovered a groundbreaking new snakebite treatment to prevent the devastating tissue damage caused by African spitting cobra venom.

11 May 2024

Decoding Aging: The Role of Stochastic Variation in Biological Clocks

Aging clocks can measure the biological age of humans with high precision. Biological age can be influenced by environmental factors such as smoking or diet, thus deviating from the chronological age that is calculated using the date of birth.

10 May 2024

Rice University Develops AI-Powered Tools for Unraveling Microbial Genomes

Since the first microbial genome was sequenced in 1995, scientists have reconstructed the genomic makeup of hundreds of thousands of microorganisms and have even devised methods to take a census of bacterial communities on the skin, in the gut, or in soil, water and elsewhere based on bulk samples, leading to the emergence of a relatively new field of study known as metagenomics.

8 May 2024

Circadian Coordination: Key to Tissue Function and Aging Prevention

Discovered in the 1970s, circadian clocks are essential for the regulation of biological time in most cells in the human body.

3 May 2024

Novel Lantibiotic Unveiled Against Skin Microbiome Rivals

Many bacteria produce substances to gain an advantage over competitors in their highly competitive natural environment.

30 Apr 2024

Investigating Enhancer Function in Pluripotent Stem Cells

As embryos, all complex organisms are partially made up of pluripotent stem cells, a term for cells that have the capacity to differentiate into any kind of cell: nerve cells, muscle cells, blood cells, skin cells, and the like.

30 Apr 2024

New Organoid Model Offers Opportunities to Study Thymus Function

Researchers from the Organoid group have developed a new organoid model that can be used to study the thymus.

30 Apr 2024

Epigenetics May Spark Tumors Without DNA Mutations

Scientists from the CNRS are part of a research team that has found that epigenetic changes, or modifications that affect the regulation of gene expression, can be the sole cause of cancer, one of the world's leading causes of death.

25 Apr 2024

Microfluidics Paves the Way for More Efficient Neural Stem Cell Generation

Swedish researchers have enhanced a method for transforming ordinary skin cells into neural stem cells, a development they believe narrows the accessibility gap for personalized cell-based therapies for Alzheimer's and Parkinson's diseases.

25 Apr 2024

Ancient Gene Holds Key to Mammalian Gliding

People say "When pigs fly" to describe the impossible. But even if most mammals are landlubbers, the ability to glide or fly has evolved again and again during mammalian evolution, in species ranging from bats to flying squirrels.

25 Apr 2024

Unveiling the Evolutionary Origins of Bilaterian Species

700 million years ago, a remarkable creature emerged for the first time. Though it may not have been much to look at by today's standards, the animal had a front and a back, a top and a bottom.

16 Apr 2024

Cell's Garbage Disposal May Also Send Sensory Signals Beyond Recycling

The proteasome, the cell's garbage disposal mechanism, usually breaks down proteins into smaller pieces and recycles some of the pieces.

15 Apr 2024

Can Pets Harbor and Spread Antibiotic-Resistant Bacteria?

According to new research, pet dogs and cats are major contributors to the spread of bacteria resistant to antibiotics.

15 Apr 2024

Genomic Deletions Drive Development of Melanoma Drug Resistance

Melanoma is the deadliest form of skin cancer. With global incidence rates rising, new, more effective treatments are necessary to alleviate the health burden of the disease. Important advances in recent years include doctors using genetic tests to look for specific mutations they can target for more personalised, effective treatment.

15 Apr 2024

Different Chromosomes Found to Have Separate End-Specific Telomere-Length Distributions

We depend on our cells being able to divide and multiply, whether it's to replace sunburnt skin or replenish our blood supply and recover from injury.

12 Apr 2024

New Platform Reveals Individual Sensitivity to Disease-Causing Mutations

In humans, the exact same mutation in a specific gene can produce widely different outcomes. It's a bit like adding the same amount of salt to different recipes-;the effect on the finished dish can be quite different, depending on the mix of other ingredients.

4 Apr 2024

New Virus Offers Hope for Amphibians Ravaged by Fungus

A fungus devastating frogs and toads on nearly every continent may have an Achilles heel. Scientists have discovered a virus that infects the fungus, and that could be engineered to save the amphibians.

4 Apr 2024