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Researchers Identify Natural Compounds for Parasitic Worm Treatment

An international team led by researchers at the University of Toronto has found a family of natural compounds with potential as new and more effective treatments for parasitic worms.

9 May 2024

UCLA Study Reveals Novel Mechanism for Memory Formation During Sleep

UCLA Health researchers have discovered a mechanism that creates memories while reducing metabolic cost, even during sleep.

9 May 2024

Hydrogel Therapy: A Novel Defense Against Viral Infections

Vaccines remain the gold standard of protection against dangerous pathogens, but take considerable time and vast resources to develop.

24 Apr 2024

Leveraging the Materiobiology Approach to Design Biomaterials for Aged Bone Repair

In the elderly, a multitude of factors contribute to diminished bone regeneration capabilities, including a reduction in the self-renewal and differentiation abilities of mesenchymal stem cells, an excessive accumulation of inflammatory signals, compromised blood vessel regeneration capacity, an imbalance between bone anabolism and catabolism, and inadequate bone innervation.

13 Apr 2024

Non-Immune Cells Form Memory, Boosts Inflammatory Response

An essential component of adaptive immunity is immunological memory, which is the capacity to react to a foreign material or antigen more quickly and intensely when exposed again.

21 Mar 2024

DNA Origami Revolutionizes Cancer Immunotherapy: The DoriVac Breakthrough

Therapeutic cancer vaccines are a form of immunotherapy in the making that could not only destroy cancer cells in patients, but keep a cancer from coming back and spreading.

15 Mar 2024

uLIPSTIC Tool: Tracking Cell-to-Cell Interactions

Gaining an understanding of how various cell types cooperate to form tissues, organs, and organ systems is one of the main objectives of basic biology.

8 Mar 2024

Researchers Identify Proteins to Reprogram Fibroblasts into Limb Progenitor Cells

In a collaborative study, researchers from Kyushu University and Harvard Medical School have identified proteins that can turn or "reprogram" fibroblasts -; the most commonly found cells in skin and connective tissue -; into cells with similar properties to limb progenitor cells.

5 Mar 2024

Scientists Discover Dual Challenges in DNA Replication Process

Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how our DNA gets copied.

29 Feb 2024

Discovery of a Subset of Human Short Introns That Are Spliced Out by a Novel Mechanism

The well-known essential pre-mRNA splicing factor U2AF heterodimer (U2AF2–U2AF1) has been considered to mediate early splicing reaction in all introns of different lengths.

15 Feb 2024

Identifying Phosphorylation Sites in Legume-Rhizobia Symbiosis

Legume plants are unique in that they can interact with rhizobia, which are soil-dwelling bacteria that fix nitrogen.

13 Feb 2024

Safer and More Effective Cell Therapy for Spinal Cord Injuries

For patients with spinal cord injuries, a small gadget developed by researchers at MIT and the Singapore-MIT Alliance for Research and Technology may help to increase the efficacy and safety of cell therapy treatments.

8 Feb 2024

How the Brain Controls its Cravings for Water and Salt

For terrestrial creatures, including humans, to survive, they must drink plenty of water and eat enough salt. Neural pathways comprising many brain regions intriguingly control both thirst and salt appetite.

29 Jan 2024

Boosting Central Memory T Cells with Targeted Protein Modulation

The Hackensack Meridian Center for Discovery and Innovation's (CDI) Xue Lab has made yet another advancement in the understanding of the immune system and its potential for disease-fighting modulation.

22 Jan 2024

Breakthrough 3D Vascular Sheet Mimics Atherosclerosis for High-Throughput Drug Screening

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials.

16 Jan 2024

Novel Amino Acid Nanoparticles Offer Hope for Fighting Multi-Drug Resistant Cancers

Amino acids, such as tyrosine and tryptophan, are the fundamental building blocks that make up proteins.

9 Jan 2024

Breakthrough in Synthetic Biology: Researchers Build Artificial CO2-Fixing Pathway

Synthetic biology offers the opportunity to build biochemical pathways for the capture and conversion of carbon dioxide (CO2).

3 Jan 2024

Mettl3 Drives Powerful Immune Defense of CD8 T Cells

This study is led by Dr. Shuyang Yu (College of Biological Sciences, China Agricultural University), Dr. Jingyu Xu (The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University) and Dr. Xuguang Du (College of Biological Sciences, China Agricultural University) and illustrated the key role of Mettl3 in CD8 T cell response during acute infection model.

2 Jan 2024

AI-Powered Drug Breakthrough: Insilico Unveils Potent FGFR2/3 Inhibitor for Solid Tumors

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

29 Dec 2023

Xeno-Free Monkey PSC Culture System Enables Deriving, Tracking, and Differentiating Stem Cells

Non-human primates (NHPs) have a high degree of similarity to humans compared to other animal models.

26 Dec 2023