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AI-Driven Insights into Lasso Peptide Biosynthesis

Lasso peptides are natural products made by bacteria. Their unusual lasso shape endows them with remarkable stability, protecting them from extreme conditions. In a new study, published in Nature Chemical Biology, researchers have constructed and tested models for how these peptides are made and demonstrated how this information might be used to advance lasso peptide-based drugs into the clinic.

23 Sep 2024

Sodium Transport Found to Play a Surprising Role in Mitochondrial Energy Production

The GENOXPHOS (Functional Genetics of the Oxidative Phosphorylation System) group at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has discovered a crucial role of sodium in the generation of cellular energy.

20 Sep 2024

Low Extracellular Sodium Concentrations Can Suppress mRNA Expression in Brain Cells

Brain and mental problems can result from chronic hyponatremia, a disorder marked by low blood salt levels.

19 Sep 2024

PKN Inhibition Reduces Cardiac Fibrosis and Improves Heart Function

The number of people suffering from heart failure is rising quickly as society ages. Heart failure progression is linked to fibrosis, or the overgrowth of fibrotic tissue in the heart.

16 Sep 2024

Potassium Isotope Ratios: A Potential Biomarker for Early Alzheimer's Disease Diagnosis

Potassium isotope ratios in serum show promise as biomarkers for Alzheimer's disease, revealing significant differences between patients and healthy controls.

16 Sep 2024

Automated DNA Separation for Sexual Assault Cases: A Breakthrough in On-Site Forensic Analysis

This study presents a digital microfluidics approach for rapid DNA extraction from sexual assault samples, significantly improving forensic analysis efficiency.

11 Sep 2024

CRISPR/Cas System Revolutionizes Tumor Variant and Biomarker Detection

The CRISPR-Cas system is transforming tumor biomarker detection, enabling ultra-sensitive diagnostics and improving accuracy in cancer detection and monitoring.

4 Sep 2024

The Molecular Process That Causes MS and Autoimmune Diseases

A human immune system suppressor known as “regulatory T cells” was first identified more than 20 years ago by a research team working in the lab of Yale researcher David Hafler, who was at Harvard at the time.

29 Aug 2024

Bifidobacterium in Maternal Gut Found to Alter Fetal Brain Growth

Bifidobacterium breve supplementation in pregnant mice alters fetal brain metabolism, highlighting its role in enhancing gestational health and development.

29 Aug 2024

The Influence of 'Silent' Mutations on Genetic Disorders

Genetic disorders -; like cystic fibrosis and Huntington's disease -; are considered incurable, with gene mutations occurring in essentially every cell of the body.

29 Aug 2024

Cryo-EM Study Sheds Light on HSV Drug Resistance Mechanisms Through Protein Movement

All organisms -; from fungi to mammals -; have the capacity to evolve and adapt to their environments. But viruses are master shapeshifters with an ability to mutate greater than any other organism. As a result, they can evade treatments or acquire resistance to once-effective antiviral medications.

28 Aug 2024

Unraveling the Molecular Mechanism Behind Neocapritermes taracua's Explosive Defense

Researchers from the Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, in cooperation with colleagues from the Faculty of Tropical AgriScience of the Czech University of Life Sciences in Prague, are unraveling the mysteries of the life of termites.

28 Aug 2024

Engineering Purple Bacteria for Enhanced Bioplastic Synthesis

In a world overrun by petroleum-based plastics, scientists are searching for alternatives that are more sustainable, more biodegradable and far less toxic to the environment.

27 Aug 2024

Cryo-EM Reveals CDCA7's Hemimethylation Sensing in Nucleosome Core Particles

DNA methylation, a process by which methyl groups are added to DNA molecules, is essential for the maintenance of DNA and the overall health of an organism. Disruptions in the standard DNA methylation patterns can lead to immunodeficiency and diseases such as cancer.

27 Aug 2024

New Human Intestinal Immuno-Organoids Reveal Insights into Immune Cell Dynamics and Cancer Immunotherapy

Research on intestinal immuno-organoids reveals their potential in modeling immune interactions and studying intestinal diseases linked to cancer therapies.

26 Aug 2024

The Complex Link Between DNA Modification and ALS

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease which remains incurable. The disease is characterized by the selective degeneration of upper motor neurons in the motor cortex as well as the lower motor neurons in the brainstem and spinal cord. The cause of ALS remains unknown in 90 percent of cases, which are referred to as sporadic ALS because there is no family history for the disease. Cumulative evidence suggests that sporadic ALS may result from complex interactions between genetic susceptibility and aging.

23 Aug 2024

Enzyme Therapy Shows Promise for Parkinson's Disease

A preclinical investigation conducted by Weill Cornell Medicine researchers has shown an unexpectedly important role for an enzyme called PGK1 in the synthesis of chemical energy in brain cells.

22 Aug 2024

Understanding the Molecular Basis of Avian Influenza Host Shift

A recent study by the Cusack group clarifies how a crucial enzyme of the avian influenza virus can change, enabling the virus to spread to mammals.

20 Aug 2024

Harnessing Proteomics to Explore the Role of Probiotic Bacteria in Human Health

The currently available proteomics strategies can be used to identify and quantify probiotic bacterial proteins.

19 Aug 2024

Researchers Uncover Role of OpgH in Bacterial Cell Shape

In what they labeled a "surprising" finding, Johns Hopkins Medicine researchers studying bacteria from freshwater lakes and soil say they have determined a protein's essential role in maintaining the germ's shape. Because the integrity of a bacterial cell's "envelope" or enclosure is key to its survival, the finding could advance the search for new and better antibiotics.

16 Aug 2024

Enzyme News and Research

AI-Driven Insights into Lasso Peptide Biosynthesis

Sodium Transport Found to Play a Surprising Role in Mitochondrial Energy Production

Low Extracellular Sodium Concentrations Can Suppress mRNA Expression in Brain Cells

PKN Inhibition Reduces Cardiac Fibrosis and Improves Heart Function

Potassium Isotope Ratios: A Potential Biomarker for Early Alzheimer's Disease Diagnosis

Automated DNA Separation for Sexual Assault Cases: A Breakthrough in On-Site Forensic Analysis

CRISPR/Cas System Revolutionizes Tumor Variant and Biomarker Detection

The Molecular Process That Causes MS and Autoimmune Diseases

Bifidobacterium in Maternal Gut Found to Alter Fetal Brain Growth

The Influence of 'Silent' Mutations on Genetic Disorders

Cryo-EM Study Sheds Light on HSV Drug Resistance Mechanisms Through Protein Movement

Unraveling the Molecular Mechanism Behind Neocapritermes taracua's Explosive Defense

Engineering Purple Bacteria for Enhanced Bioplastic Synthesis

Cryo-EM Reveals CDCA7's Hemimethylation Sensing in Nucleosome Core Particles

New Human Intestinal Immuno-Organoids Reveal Insights into Immune Cell Dynamics and Cancer Immunotherapy

The Complex Link Between DNA Modification and ALS

Enzyme Therapy Shows Promise for Parkinson's Disease

Understanding the Molecular Basis of Avian Influenza Host Shift

Harnessing Proteomics to Explore the Role of Probiotic Bacteria in Human Health

Researchers Uncover Role of OpgH in Bacterial Cell Shape

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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