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Unlocking the Mysteries of Repeat Expansion in Genetics

Research led by scientists at Queen Mary University of London is heralding in a new era for genetic sequencing and testing.

3 Oct 2024

Bipolar Disorder and Epilepsy Share Genetic Roots

A team of researchers from the Chinese Academy of Sciences has uncovered compelling evidence of a genetic link between bipolar disorder type I (BD-I) and epilepsy, potentially revolutionizing our understanding of these complex neuropsychiatric conditions.

1 Oct 2024

A Novel Genetic Inference Method for Detecting Rare Disease Variants

Undiagnosed cases of Long QT syndrome have been found, thanks to an inventive examination of shared genomic sequences, which is a sign of distant “relatedness” and can cause irregular heart rhythms, fainting, and sudden cardiac death.

30 Sep 2024

Huntington's Disease Protein Disrupts DNA Repair

Researchers at McMaster University have found that the mutated protein in Huntington's disease patients disrupts DNA repair as it should, which affects the capacity of brain cells to regenerate.

30 Sep 2024

Study Confirms Comparable Efficacy of Lamotrigine and Mexiletine in Muscle Channelopathy

The study, published in Lancet Neurology, detailed the "head-to-head" trial implemented by the researchers to test two drugs, mexiletine and lamotrigine, on people with the condition.

30 Sep 2024

The Role of Macrophages in Shaping the Inflammatory Environment in Rheumatoid Arthritis

Currently there are no cures for rheumatoid arthritis (RA) which affects 40,000 people in Ireland. The disease costs an estimated €20,000 per patient, per year with an overall cost to the health system of ~€544 million. Only 1 in 4 patients achieve remission and a significant proportion of patients have suboptimal responses or no response at all to current available therapies.

30 Sep 2024

Research Reveals How the Brain Encodes Time and Experiences at the Neuronal Level

A landmark study led by UCLA Health has begun to unravel one of the fundamental mysteries in neuroscience – how the human brain encodes and makes sense of the flow of time and experiences.

26 Sep 2024

blotRig Tool Transforms Western Blot Design and Statistical Analysis for Reproducibility

Improving reproducibility in Western blot experiments through rigorous design and advanced statistical analysis is crucial for accurate protein quantification.

26 Sep 2024

The Lasting Effects of COVID-19 on the Brain

In the UK’s largest study to date, novel steps have been taken to gain a better understanding of the immediate and long-term effects of COVID-19 on the brain.

25 Sep 2024

A Computational Toolkit for Large-Scale Metabolomics Analysis

A computational workflow for analyzing massive data sets in metabolomics, the study of tiny chemicals found within cells, biofluids, tissues, and entire ecosystems has been developed by a research team led by experts at the University of California, Riverside.

23 Sep 2024

Sodium Transport Found to Play a Surprising Role in Mitochondrial Energy Production

The GENOXPHOS (Functional Genetics of the Oxidative Phosphorylation System) group at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has discovered a crucial role of sodium in the generation of cellular energy.

20 Sep 2024

Low Extracellular Sodium Concentrations Can Suppress mRNA Expression in Brain Cells

Brain and mental problems can result from chronic hyponatremia, a disorder marked by low blood salt levels.

19 Sep 2024

Early Detection of Off-Target Binding Could Improve Drug Safety

Integral Molecular, a pioneer in antibody discovery and characterization, has published new findings in the journal mAbs, revealing that up to one-third of antibody-based drugs exhibit nonspecific binding to unintended targets.

18 Sep 2024

One-Third of Antibody Drugs Show Unintended Target Binding

Integral Molecular, a leader in antibody discovery and characterization, has published new research in the journal mAbs, revealing that as many as one-third of antibody-based drugs exhibit nonspecific binding to unintended targets.

18 Sep 2024

Lipids Found to Play Key Role in Cancer Immune Evasion

Cancer cells seldom start off stealthy. Quite to the contrary, they announce their presence to the immune system by planting chemical red flags right on their membranes.

18 Sep 2024

Breakthrough Discovery on How TGF-Beta Communicates in Cells

Scientists discover how TGF-Beta, a crucial protein in development and cancer, sends its message even while tethered to the cell membrane.

17 Sep 2024

Potassium Isotope Ratios: A Potential Biomarker for Early Alzheimer's Disease Diagnosis

Potassium isotope ratios in serum show promise as biomarkers for Alzheimer's disease, revealing significant differences between patients and healthy controls.

16 Sep 2024

CHIEF Model Transforms Cancer Evaluation with Enhanced Generalizability Across Diverse Histopathology Samples

The CHIEF model revolutionizes cancer diagnosis, leveraging histopathological imaging to predict tumor origins and survival outcomes with exceptional accuracy.

16 Sep 2024

New Initiative Targets High-Risk Genes to Understand Neurodevelopmental and Psychiatric Disorders

Neurodevelopmental and psychiatric disorders (NPD) including schizophrenia, bipolar disorder, autism, and depression are detrimental to individuals, their families and society as a whole, and in many cases still lack effective treatments.

13 Sep 2024

CRISPR and Antibodies Offer New Hope for Improving CAR-T Cell Therapy Outcomes

Mayo Clinic researchers mined the molecular foundations of cancer and uncovered a new reason chimeric antigen receptor (CAR-T cell therapy) fails in some patients.

13 Sep 2024

Clinical News and Research

Unlocking the Mysteries of Repeat Expansion in Genetics

Bipolar Disorder and Epilepsy Share Genetic Roots

A Novel Genetic Inference Method for Detecting Rare Disease Variants

Huntington's Disease Protein Disrupts DNA Repair

Study Confirms Comparable Efficacy of Lamotrigine and Mexiletine in Muscle Channelopathy

The Role of Macrophages in Shaping the Inflammatory Environment in Rheumatoid Arthritis

Research Reveals How the Brain Encodes Time and Experiences at the Neuronal Level

blotRig Tool Transforms Western Blot Design and Statistical Analysis for Reproducibility

The Lasting Effects of COVID-19 on the Brain

A Computational Toolkit for Large-Scale Metabolomics Analysis

Sodium Transport Found to Play a Surprising Role in Mitochondrial Energy Production

Low Extracellular Sodium Concentrations Can Suppress mRNA Expression in Brain Cells

Early Detection of Off-Target Binding Could Improve Drug Safety

One-Third of Antibody Drugs Show Unintended Target Binding

Lipids Found to Play Key Role in Cancer Immune Evasion

Breakthrough Discovery on How TGF-Beta Communicates in Cells

Potassium Isotope Ratios: A Potential Biomarker for Early Alzheimer's Disease Diagnosis

CHIEF Model Transforms Cancer Evaluation with Enhanced Generalizability Across Diverse Histopathology Samples

New Initiative Targets High-Risk Genes to Understand Neurodevelopmental and Psychiatric Disorders

CRISPR and Antibodies Offer New Hope for Improving CAR-T Cell Therapy Outcomes

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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