Histones News and Research

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Researchers identify a novel approach that sheds light on epigenetics

A new Cornell research throws light on a contentious dispute in epigenetics.

16 Mar 2022

New technique controls gene activity without altering the DNA sequence of the genome

By combining CRISPR technology with a protein designed with artificial intelligence, it is possible to awaken individual dormant genes by disabling the chemical "off switches" that silence them.

7 Mar 2022

Hematopoietic stem cells play key focus of stem-cell-based medical research

According to a recent study, a protein that controls how DNA is wrapped within chromosomes plays a key role in the proper functioning of blood stem cells.

2 Feb 2022

Study may pave the way for designing next generation of artificial chromosomes for data storage

Previously, researchers from Tianjin University designed and created a 254 kb digital data carrying artificial chromosome in yeast.

12 Jan 2022

Research shows how bacteria silence potentially deadly genes

Humans are all made of collections of cells, where each cell contains instructions in the DNA to become another cell.

7 Jan 2022

Experts identify proteins that regulate dual processes

According to recent research, the protein UBR7 acts as a histone chaperone and controls histone re-deposition at certain sites at the time of DNA replication.

22 Dec 2021

Developing Sperm Cells from Primate Stem Cells

We speak to Professor Charles Easley about his latest research into male infertility, and how sperm cells could be potentially developed from primate stem cells.

From University of Georgia 15 Dec 2021

Researchers identify a new approach to triggering differentiation in acute myeloid leukemia

In the late 1980s, scientists developed a revolutionary approach to treating acute myeloid leukemia (AML), a type of blood cancer. Called differentiation therapy, it amounted to a bona fide cure for many patients.

2 Dec 2021

Study sheds light on the regulation of epigenetic modifications during the development

The hereditary material, DNA, interacts with proteins present in the cell nuclei and forms a tightly packed complex with proteins called “chromatin”.

29 Oct 2021

Scientists find two proteins that pair up to build lifelines to cancer cells

In human cancer cell and mouse studies, researchers from Johns Hopkins Medicine have found that a set of proteins work in tandem to build supply lines that deliver oxygen and nutrients to tumors, enabling them to survive and grow.

21 Sep 2021

Changes in epigenome responsible for reduced stem cell function upon aging

The bones become thinner with age, resulting in frequent fractures and making them susceptible to bone diseases like osteoporosis.

From The Max Planck Institute 20 Sep 2021

Study uncovers mechanism where two transcription factors stabilize each other’s binding to DNA

Researchers have discovered an exclusive mechanism through which two transcription factors stabilize each other’s binding to DNA in fission yeast.

14 Sep 2021

New approach uses engineered yeast cells to study proteins that regulate gene expression

Researchers have developed a more efficient platform for studying proteins that play a key role in regulating gene expression. The approach uses engineered yeast cells to produce enzyme and histone proteins, conduct biochemical assays internally, and then display the results.

2 Jul 2021

Study explains the rapid adaptation of plants to changing environmental conditions

For a long time, researchers and gardeners have known that plants grow taller and flower sooner when they are surrounded by other close-growing flora.

2 Jul 2021

First real-time observation of DNA-histone interactions

The genetic material of most organisms is carried by DNA, a complex organic molecule. DNA is very long -- for humans, the molecule is estimated to be about 2 m in length.

2 Jun 2021

Study shows that inactivation of BRG1 leads to high genetic instability

Following the p53 tumor suppressor gene, the genes encoding two proteins of the SWI/SNF chromatin remodeling complex are the most often identified mutated.

17 May 2021

Cancer cells re-organize DNA structure to ramp up the activity of oncogenes

A lot of biological mechanisms go wrong in cancer—for example genes mutate and cells proliferate in an uncontrollable manner.

11 May 2021

Researchers study the unique genomic organization of coral symbionts

According to recent findings, the genome of single-celled plankton, called dinoflagellates, is arranged in an extremely unusual and strange manner. The study results set the foundations for further research into these vital aquatic species and significantly broaden the understanding of what a eukaryotic genome can look like.

3 May 2021

DNAJC9 protein plays a key role in protecting histones in the cell nucleus

Histones play an important role in the cell nucleus by packaging DNA into chromatin.

15 Apr 2021

New method helps map the epigenetics of mouse brain

Histones are essentially small proteins that attach to DNA and store information that can be used to switch individual genes on or off.

14 Apr 2021