Neurodegenerative Diseases News and Research

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New Insights into the Mechanism of Glycan Branch Formation

Glycans are sugar chains that bind to cells via proteins or lipids, altering their chemical properties

30 Oct 2024

C. elegans Model Revolutionizes Search for Amyloid Inhibitors

An international team led by researchers at the University of Toronto has developed an efficient and robust system, using the C. elegans nematode, to screen for compounds that can stop the growth of amyloid proteins.

29 Oct 2024

Study Uncovers How MANF Protein Enhances Cellular Homeostasis and Longevity

McMaster University researchers have discovered a previously unknown cell-protecting function of a protein, which could open new avenues for treating age-related diseases and lead to healthier aging overall.

21 Oct 2024

A Novel Regulator of RNA Processing in Alzheimer's Disease

A research team from the University of Barcelona's Institute of Neurosciences described a novel molecular mechanism that modifies the process of protein synthesis and impacts RNA processing in Alzheimer's patients' brains.

21 Oct 2024

MANF Protein Found to Boost Cellular Clean-Up and Efficiency

Researchers at McMaster University have uncovered a previously unrecognized function of a protein that helps protect cells, potentially leading to new treatments for age-related conditions and promoting healthier aging.

18 Oct 2024

Researchers Develop Fluorescent Biosensor to Study PKC Activity

Working in organoid models, researchers at University of California San Diego School of Medicine have developed a new tool to study protein-kinase C (PKC) enzymes, which play a critical role in cell growth, differentiation and survival.

14 Oct 2024

Study Unravels the Mystery of Hsp70 Chaperones

Proteins control most of the body's functions, and their malfunction can have severe consequences, such as neurodegenerative diseases or cancer. Therefore, cells have mechanisms in place to control protein quality.

9 Oct 2024

Scientists Uncover Secrets of Circadian Rhythm Control

Scientists from Duke-NUS Medical School and the University of California, Santa Cruz, have discovered the secret to regulating our internal clock.

8 Oct 2024

Two Alzheimer’s Genetic Risk Factors Trigger Harmful Inflammation in Females

Weill Cornell Medicine investigators have found that two genetic variants that confer high risk of Alzheimer's disease (AD) together trigger a harmful inflammatory response in the brain's immune cells, particularly in females, in a preclinical model.

1 Oct 2024

Gut Bacteria Influence Hormonal Balance and Hypopituitarism Symptoms in Mice

Researchers at the Francis Crick Institute have shown that the balance of bacteria in the gut can influence symptoms of hypopituitarism in mice.

27 Sep 2024

Sodium Transport Found to Play a Surprising Role in Mitochondrial Energy Production

The GENOXPHOS (Functional Genetics of the Oxidative Phosphorylation System) group at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has discovered a crucial role of sodium in the generation of cellular energy.

20 Sep 2024

UChicago Team Secures $7.4 Million Grant to Study Cellular Adaptation

Cells use a variety of processes to adapt to changes and stressors in their environment, like increased temperature.

21 Aug 2024

Rapid Parkinson's Model Opens Door to Personalized Treatments

Scientists at Brigham and Women’s Hospital, a key member of the Mass General Brigham healthcare system, have created a model that swiftly transforms stem cells into brain cells exhibiting protein structures associated with Parkinson’s disease (PD).

30 Jul 2024

Traffic-Related Ultrafine Particles Cause Mitochondrial Dysfunction in Olfactory Mucosa

Ultrafine particles, UFPs, the smallest contributors to air pollution, hinder the function of mitochondria in human olfactory mucosa cells, a new study shows.

25 Jul 2024

New Tool GeneMAP Unveils Key Insights into Cell Metabolism

There's a glaring gap in our knowledge of cell metabolism: in many cases, we still don't know exactly how nutrients are transported into the cell.

24 Jul 2024

Macrophage Inflammation may Contribute to LSD Symptoms

Researchers at The Hospital for Sick Children (SickKids) have found that inflammation in an immune cell may be responsible in part for some severe symptoms in a group of rare genetic conditions called lysosomal storage diseases (LSDs).

15 Jul 2024

A New Tool to Unravel the Mysteries of Metabolic Genes

A novel discovery platform has been created by a multidisciplinary research team to investigate the role of genes involved in metabolism, which is the culmination of all chemical reactions necessary for life.

9 Jul 2024

UCL Study Uncovers Astrocytes' Role in Brain Energy Boosting Mechanism

A key mechanism which detects when the brain needs an additional energy boost to support its activity has been identified in a study in mice and cells led by UCL scientists.

4 Jul 2024

Novel Epigenetic Tool CHARM Offers Hope for Prion Disease Treatment

In a new study in mice, researchers introduce "CHARM," a compact and versatile epigenetic editor that can be used to silence prion protein throughout the brain.

28 Jun 2024

Breakthrough in Understanding Connexin-Drug Interactions

Researchers have gained new knowledge of how drugs bind to connexin molecules. These molecules form channels that allow neighboring cells to send direct messages to one another.

27 Jun 2024