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Versatile, Language-Based Approach Aids in the Design of New Proteins

Researchers discovered a new type of marine bacteria with distinct traits on the ocean floor.

30 Aug 2023

Age-Related Hearing Loss Associated With Decrease of Cholesterol in the Inner Ear

Researchers led by María Eugenia Gomez-Casati, the Institute of Pharmacology, School of Medicine, University of Buenos Aires-CONICET; Mauricio Martin, the Institute of Medical Research Mercedes; and Martín Ferreyra, (INIMEC-CONICET-UNC), National University of Córdoba in Argentina report that age-related hearing loss is associated with a decrease of cholesterol in the inner ear.

25 Aug 2023

Single Injection of CRISPR Gene-Editing Treatment Safely Removes SIV From Non-Human Primates

A single injection of a novel CRISPR gene-editing treatment safely and efficiently removes SIV – a virus related to the AIDS-causing agent HIV – from the genomes of non-human primates, scientists at the Lewis Katz School of Medicine at Temple University now report.

17 Aug 2023

Scaffolding Protein Helps in the Creation of Biomolecular Condensate

Biomolecular condensates are loosely organized assemblies that carry out a variety of vital tasks inside all live cells. However, the mechanism by which proteins and other biomolecules combine to create these assemblies within cells is not fully known.

16 Aug 2023

Unique Molecular Structure Has Effects on Age-Related Diseases

The mitochondria, sometimes known as the “powerhouses of the cell,” are widely recognized for their function as energy producers, but these organelles are also essential for preserving general health.

8 Aug 2023

Organization of Cells Using Polyelectrolyte Complexes

It has long been understood that a certain sort of molecular assembly called a “polyelectrolyte complex” aids the cells in maintaining their own organization.

1 Aug 2023

5-ALA Opens New Avenues for Treating Mitochondrial Disorders

At the Tokyo Metropolitan University, researchers have shown that 5-aminolevulinic acid (5-ALA) aids bypass deficiencies in Complex I (CI), the first in a series of protein complexes that transport electrons and assist in powering the mitochondria.

17 Jul 2023

Revealing the Function of Retrotransposons

A retrotransposon, a parasitic DNA sequence that borrows the cell’s own machinery to accomplish its objectives, has been discovered.

13 Jul 2023

Trim24 Limits the Ability of p53 to Function as a Tumor Suppressor

The tumor suppressor protein p53 has been nicknamed the “guardian of the genome” because it safeguards the DNA from long-term damage or stress by controlling the expression of numerous genes involved in DNA repair, cell division, and cell death.

3 Jul 2023

Loss of the Y Chromosome Impairs Body's Ability to Fight Cancer

According to recent Cedars-Sinai Cancer research, as men age, some of their cells lose the very feature that makes them biological males—the Y chromosome—and this loss impairs the body’s ability to fight cancer.

22 Jun 2023

Microglial Cells Serve as a Stable Viral Reservoir for Latent HIV

Human immunodeficiency virus-1 (HIV) introduces a copy of its DNA into human immune cells as part of its life cycle. Some of these newly infected immune cells can subsequently enter an inactive, latent state for an extended length of time, which is known as HIV latency.

19 Jun 2023

Understanding How Genes Predispose Humans to Allergies

New research is expanding the scientific understanding of why some people are more allergic than others. Researchers at the University of Pennsylvania’s Perelman School of Medicine discovered how genetic changes that modify a specific protein called ETS1 can affect our body’s response to allergens.

16 Jun 2023

Newly Identified Cellular Mechanism Enhances Photosynthesis in Marine Phytoplankton

Take a deep breath. Now take nine more. According to new research, the amount of oxygen in one of those 10 breaths was made possible thanks to a newly identified cellular mechanism that promotes photosynthesis in marine phytoplankton.

1 Jun 2023

New Phenology Product Monitors the Climate Change Impacts on Terrestrial Ecosystems

The cycle sequence of important activities in vegetation is a particularly sensitive indicator of climatic changes in terrestrial ecosystems. Most recent studies have focused on structural changes in plants, such as employing greenness indicators to represent the growth process of leaves.

30 May 2023

Virally Mediated Gene Therapy Rescues Hearing in Aging Mice

By 2050, one in 10 individuals are expected to live with some form of hearing loss. Of the hundreds of millions of cases of hearing loss affecting individuals worldwide, genetic hearing loss is often the most difficult to treat.

29 May 2023

Novel Gene-Editing Strategy Harnesses Unusual Protective Ability to Eliminate HIV-1 Infection

Genetic alterations that give rise to a rare, fatal disorder known as MOGS-CDG paradoxically also protect cells against infection by viruses.

22 May 2023

Reducing Intracellular Ice Formation in Advanced Cell Models

Researchers at the University of Warwick have discovered a way for storing advanced cell models.

From The University of Warwick 3 May 2023

The Pivotal Role of Combinatorial CRISPR Gene Editing in the Elimination of HIV-1 Infection

Recent research from Temple University’s Lewis Katz School of Medicine and the University of Nebraska Medical Center demonstrates that gene-editing therapy aimed at two targets - HIV-1, the virus that causes AIDS, and CCR5, the co-receptor that aids the virus getting into cells—can effectively eliminate HIV infection.

2 May 2023

Previously Unknown Regulatory Mechanism for Circadian and Temperature Signaling Pathways Revealed

Ever wondered why people become tired when the sun goes down? What causes some flower petals to open during the day and close at night? Or how monarch butterflies ascertain when to migrate south?