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First-in-human clinical trial to test safety, efficacy of gene therapy for Alzheimer's disease

Researchers at University of California San Diego School of Medicine have launched a first-in-human Phase I clinical trial to assess the safety and efficacy of a gene therapy to deliver a key protein into the brains of persons with Alzheimer's disease (AD) or Mild Cognitive Impairment (MCI), a condition that often precedes full-blown dementia.

From UC San Diego 19 Feb 2021

Using soil bacteria for antibiotic production

In this interview, AZoLifeSciences speaks to Dr. Christophe Corre about his latest research that investigated soil bacteria and how it could be used to produce antibiotics.

From The University of Warwick 19 Feb 2021

Cryogenic electron microscopy reveals shape of glutamate transporters involved in neurological diseases

An international research team has uncovered the shape of the glutamate transporter and helps explain how the human brain cells interact with each other.

18 Feb 2021

Almost one in five people lack key protein in their muscle fibers

About one in five individuals do not have the α-actinin-3 protein in their muscle fiber.

18 Feb 2021

Study reveals novel antibody binding implicated in liver and breast cancer

In the field of structural biology, certain molecules are so uncommon that they can only be captured with a special set of tools.

18 Feb 2021

Study identifies how CTLA-4 blockade can disable suppressive immune cells to aid tumor destruction

A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors.

18 Feb 2021

Research links blood-clotting protein with CNS B-cell lymphoma growth

In people with central nervous system (CNS) lymphoma, cancerous B cells--a type of white blood cell--accumulate to form tumors in the brain or spinal cord, often in close proximity to blood vessels.

18 Feb 2021

Study identifies 20 "hot spots of opportunity" for nitrogen reduction efforts

A pioneering study of U.S nitrogen use in agriculture has identified 20 places across the country where farmers, government, and citizens should target nitrogen reduction efforts.

18 Feb 2021

Understanding the herbivory-sensing mechanism of plants through elicitors

Plants are known to possess solid immune response mechanisms. One such response is “sensing” attack by herbivorous animals.

From Tokyo University of Science 18 Feb 2021

New statistical study shows how pairs of cancer cells interact

One of the fundamental principles of biology is the fact that cells are motile and make contact with one another.

17 Feb 2021

Study reveals a major genetic risk factor for severe COVID-19

In 2020, a research team demonstrated that a significant genetic risk factor for severe COVID-19 infection was inherited from Neanderthals.

17 Feb 2021

Protein imbalance leads to cataract

Cataracts are the most prevalent eye disease in humans. But despite this fact, the actual processes that lead to this disease are not entirely known.

17 Feb 2021

Study shows link between metabolic and cell division mechanisms

Several biological processes are subject to rhythmic variations. Popular examples of this include the supposed circadian rhythm.

17 Feb 2021

Oncotarget review highlights molecular connections between cancer stem cells and macrophages

Oncotarget published "Cancer stem cells and macrophages: molecular connections and future perspectives against cancer" which reported that Cancer stem cells have been considered the key drivers of cancer initiation and progression due to their unlimited self-renewal capacity and their ability to induce tumor formation.

17 Feb 2021

Testing for inherited genes can help understand future cancer risk in pediatric patients

Because cancers in children are rare, many details about their biology remain unknown. In the field of cancer genetics, there's a limited understanding of how inherited genetic changes may contribute to the formation and growth of tumors.

17 Feb 2021

A new method for quantitative single-molecule colocalization analysis

WWU researchers develop a new method for quantitative single-molecule colocalization analysis /Study published in Nature Communications.

17 Feb 2021

Regular caffeine intake can change gray matter of the brain

Coffee, cola, or an energy drink: caffeine is the world's most widely consumed psychoactive substance. Researchers from the University of Basel have now shown in a study that regular caffeine intake can change the gray matter of the brain. However, the effect appears to be temporary.

17 Feb 2021

Study suggests a way to improve immunotherapy by altering immune cells’ access to sugar

Cancer cells and immune cells share something in common: They both love sugar. Sugar is an important nutrient. All cells use sugar as a vital source of energy and building blocks. For immune cells, gobbling up sugar is a good thing, since it means getting enough nutrients to grow and divide for stronger immune responses. But cancer cells use sugar for more nefarious ends.

17 Feb 2021

Researchers use zebrafish to identify role of gene involved in cardiac rhythm

Researchers have used the zebrafish (Danio rerio) to identify the role of a gene involved in cardiac rhythm, which could help explain the fundamentals of what it takes to make a human heartbeat.

17 Feb 2021

Combining cholesterol-lowering medications and lifestyle interventions may yield better benefits

Combining healthy lifestyle interventions reduces heart disease through beneficial effects on different lipoproteins and associated cholesterols, according to a study published February 9 in eLife.

17 Feb 2021

Research News and Research

First-in-human clinical trial to test safety, efficacy of gene therapy for Alzheimer's disease

Using soil bacteria for antibiotic production

Cryogenic electron microscopy reveals shape of glutamate transporters involved in neurological diseases

Almost one in five people lack key protein in their muscle fibers

Study reveals novel antibody binding implicated in liver and breast cancer

Study identifies how CTLA-4 blockade can disable suppressive immune cells to aid tumor destruction

Research links blood-clotting protein with CNS B-cell lymphoma growth

Study identifies 20 "hot spots of opportunity" for nitrogen reduction efforts

Understanding the herbivory-sensing mechanism of plants through elicitors

New statistical study shows how pairs of cancer cells interact

Study reveals a major genetic risk factor for severe COVID-19

Protein imbalance leads to cataract

Study shows link between metabolic and cell division mechanisms

Oncotarget review highlights molecular connections between cancer stem cells and macrophages

Testing for inherited genes can help understand future cancer risk in pediatric patients

A new method for quantitative single-molecule colocalization analysis

Regular caffeine intake can change gray matter of the brain

Study suggests a way to improve immunotherapy by altering immune cells’ access to sugar

Researchers use zebrafish to identify role of gene involved in cardiac rhythm

Combining cholesterol-lowering medications and lifestyle interventions may yield better benefits

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