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Gene Therapy Can Interrupt the Progression of Deadly Inherited Heart Condition

A new study in mice shows that replacement of a dysfunctional gene could prolong survival in some people with arrhythmogenic right ventricular cardiomyopathy (ARVC), a rare inherited disorder in which the muscular walls of the heart progressively weaken and put patients at risk of dangerous irregular heartbeats.

31 Jan 2024

Boosting Central Memory T Cells with Targeted Protein Modulation

The Hackensack Meridian Center for Discovery and Innovation's (CDI) Xue Lab has made yet another advancement in the understanding of the immune system and its potential for disease-fighting modulation.

22 Jan 2024

Traffic Jam in the Brain: Study Uncovers Cellular Cause of Rare Neurological Disease

Researchers from McGill University, led by Professor Alanna Watt of the Department of Biology, have identified previously unknown changes in brain cells affected by a neurological disease.

22 Jan 2024

Breakthrough 3D Vascular Sheet Mimics Atherosclerosis for High-Throughput Drug Screening

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials.

16 Jan 2024

Human Conjunctiva Model Developed For First Time

The Hubrecht Institute's Organoid group created the first organoid model of the human conjunctiva. The function of these organoids is mimicked by the human conjunctiva, a tissue involved in the formation of tears.

12 Jan 2024

AI-Powered Drug Breakthrough: Insilico Unveils Potent FGFR2/3 Inhibitor for Solid Tumors

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

29 Dec 2023

Xeno-Free Monkey PSC Culture System Enables Deriving, Tracking, and Differentiating Stem Cells

Non-human primates (NHPs) have a high degree of similarity to humans compared to other animal models.

26 Dec 2023

Brain Cell Genetics Drive Alzheimer's Progression

Developing treatments for Alzheimer's disease (AD) is difficult because complex underlying mechanisms drive different types of cells that may contribute to the disorder.

6 Dec 2023

Researchers Enhance CAR-T Cell Therapy by Preventing T-Cell Exhaustion

CAR-T cell therapy is a last hope for many patients with blood, bone marrow or lymph gland cancer when other treatments such as chemotherapy are unsuccessful.

7 Nov 2023

Developing Regenerative Therapies to Treat Neurological Conditions

The primary cells that make up our brain and spinal cord, called neurons, are among the slowest to heal after injury, and many neurons never fully recover. Although research into neural regeneration has advanced, it is still unclear why certain neurons recover while others do not.

17 Oct 2023

New Way to Visualize Tumors During Surgery

Surgeons often face the challenge of achieving precise tumor removal while preserving healthy tissue. Traditionally, they rely on their visual and tactile senses to determine where to make incisions.

17 Oct 2023

BioLizard Launches New AI-Empowered “BioVerse” Platform to Facilitate Data-Driven R&D for Global Life Sciences Community

BioLizard, the bioinformatics, data analytics and data management service and consulting company heading digital transformation in the life sciences industry, today announced the launch of its new BioVerse platform.

11 Oct 2023

New Approach to Treating Age-Related Diseases by Targeting Aging Cells

A research team, led by Professor Ja Hyoung Ryu from the Department of Chemistry at UNIST, in collaboration with Professor Hyewon Chung from Konkuk University, has achieved a significant breakthrough in the treatment of age-related diseases.

5 Oct 2023

Research Offers a Promising Avenue for Improving T-Cell-Based Cancer Therapies

Using laboratory-grown cells from humans and genetically engineered mice, scientists at Johns Hopkins Medicine say they have evidence that modifying a specific protein in immune white blood cells known as CD8+ T cells can make the cells more robust, potentially opening the door for better use of people's own immune system T cells to fight cancer.

4 Oct 2023

Pre-Targeted Radioimmunotherapy System Cures Fatal Ovarian Cancer in Preclinical Study

A new 225Ac-DOTA-based pre-targeted radioimmunotherapy (PRIT) system has been shown to cure a highly lethal form of advanced intraperitoneal ovarian cancer in a preclinical setting with minimal side effects.

19 Sep 2023

Key Proteins in Human Breast Milk Crucial for Baby’s Healthy Gut

The abundance of two species of bacteria known to be good for human health and used as probiotics, Clostridium butyricum and Parabacteroides distasonis, has been linked to high concentrations of key proteins in human breast milk, particularly osteopontin and κ-casein.

13 Sep 2023

PS Gene Editing Rebuilds Lost Neural Connections in Brain Disorder

A new study from the University of Minnesota is the first to show that gene therapy can mend neural connections in people with Hurler syndrome, a rare hereditary brain condition.

22 Aug 2023

Single Injection of CRISPR Gene-Editing Treatment Safely Removes SIV From Non-Human Primates

A single injection of a novel CRISPR gene-editing treatment safely and efficiently removes SIV – a virus related to the AIDS-causing agent HIV – from the genomes of non-human primates, scientists at the Lewis Katz School of Medicine at Temple University now report.

17 Aug 2023

Newly Developed Antibody Therapy to Have Benefits Over Existing Opioid-Overdose Treatments

An antibody in single-chain fragment variable (scFv) format that binds to the powerful opioid carfentanil was shown to reverse signs of carfentanil overdose in preclinical tests conducted by scientists at Scripps Research.

11 Aug 2023

Researchers Lead Innovative Studies on Mammalian Aging and Life Span

Scientists at UCLA David Geffen School of Medicine and UCLA Health led an international research team that published two articles detailing changes in DNA – changes that researchers found are shared by humans and other mammals throughout history and are associated with life span and numerous other traits.