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Researchers Develop Innovative Human Macrophage Model for Disease Study

A human cell culture model of the lung's most important immune cells, alveolar macrophages, helped make a key finding that is prompting researchers to rethink the role of another immune protein in infectious disease.

15 Oct 2024

New Mouse Model Shows Superior Ability to Study Human Immune Response to Cancer

Immunity plays a central role in the fight against cancer. Many of the current immunotherapies aim at helping the patient's immune system to better recognize cancer cells – by using engineered antibodies – or by simply providing it with new cells, pre-equipped to search and destroy cancer. Either way, what is paramount is a deep understanding of how the immune system works and confronts tumors.

15 Oct 2024

New Insights into How Plants Regulate Growth and Development

Plants form new leaves, flowers and roots at the tips of shoots and roots, in specific growth regions known as meristems. These meristems contain stem cells that divide as needed and form new cells that develop into specialized tissue.

15 Oct 2024

Melanin May Act as a "Drug Sponge," Influencing Medication Effectiveness

Skin pigmentation may act as a "sponge" for some medications, potentially influencing the speed with which active drugs reach their intended targets, a pair of scientists report in a perspective article published in the journal Human Genomics.

15 Oct 2024

Scientists Uncover the Hidden Order in Chaotic Embryonic Development

Pipetting liquids into tiny test tubes, analyzing huge datasets, poring over research publications-;all these tasks are part of being a scientist.

15 Oct 2024

Disrupting a Gene Boosts T Cell Therapy, St. Jude Study Shows

Immunotherapy, using a patient's own immune system to treat disease, has shown promise in some patients with cancer but has not worked in most.

15 Oct 2024

Blood Vessel Cells Play a Crucial Role in Bone Development

Researchers have discovered a protein that inhibits the activity of bone-forming cells (osteoblasts) by preventing their maturation during the process of migrating to bone-formation sites.

14 Oct 2024

Unveiling a New Cellular Phase for Protein Compartmentalization

Classical mixture theory, which takes into account the percentage corresponding to each constituent as well as the interactions among constituents, can be used to model a system made up of two substances in physics.

14 Oct 2024

New Insights Into the Antibacterial Function of GBP1 Proteins

An essential part of the human body's defense mechanism against infections is the protein GBP1.

14 Oct 2024

Human Skin Map Gives ‘Recipe’ to Build Skin and Could Help Prevent Scarring

For the first time, researchers have created a single cell atlas of prenatal human skin to understand how skin forms, and what goes wrong in disease.

From Wellcome Sanger Institute 14 Oct 2024

De Novo Antibody Protein Sequencing Reveals Novel Functional and Neutralizing Antibodies Post-SARS-CoV-2 Vaccination

Rapid Novor has published a study that highlights the power of combining de novo antibody protein sequencing with conventional proteomics to uncover functional and neutralizing antibodies in human plasma following SARS-CoV-2 vaccination.

From Rapid Novor Inc 14 Oct 2024

A New Understanding of Dragonfly Adaptation to Climate Change

Temperature determines where species can live and if they are threatened by a warming climate. So, for a long time, biologists studied how heat tolerance affects survival. Yet, less is known about how thermal traits influence reproduction, which is directly linked to extinction risk.

14 Oct 2024

A New Technique Reveals the Behavior of OPCs in the Brain

Imagine yourself sometime in the far future aboard a routine rocket to Mars. Someone just spilled their drink. Without gravity, it collects in floating blobs that ripple right before your eyes. Now freeze.

14 Oct 2024

New Research Reveals Link Between Stress Response and C. difficile Severity

The portion of our nervous systems responsible for the "fight or flight" response can shape the severity of potentially deadly C. difficile infections, new research from the University of Virginia School of Medicine reveals.

14 Oct 2024

UC San Diego and UC Berkeley Collaborate on Innovative Antibiotic Resistance Solution

University of California San Diego and University of California Berkeley researchers have been awarded up to $7 million from the Advanced Research Projects Agency for Health (ARPA-H) to conduct research under the PROTECT project -; Pro/Prebiotic Regulation for Optimized Treatment and Eradication of Clinical Threats.

14 Oct 2024

Metabolic Profiling of Lung-Resident NK Cells Reveals Novel Therapeutic Targets

Trinity College Dublin researchers, based at St James's Hospital have provided important insights into the behavior and metabolic function of a previously largely unknown, but crucial 'natural killer' (NK) immune cell resident in the lungs.

14 Oct 2024

New Research Examines the Role of Skeletal Stem Cells in Bone Growth and Regeneration

Researchers at UTHealth Houston have been awarded an $8.1 million grant by the National Institutes of Health (NIH) to examine skeletal stem cells as potential drivers of craniofacial bone diseases and deformities. The study is led by Noriaki Ono, DDS, PhD, associate professor of orthodontics, and diagnostic and biomedical sciences at UTHealth Houston School of Dentistry.

14 Oct 2024

Bacterial Gene Expression Drives the Evolution of Antibiotic Resistance

As strains of pathogens resistant to frontline antibiotics become more common worldwide, clinicians are more often turning to combination treatments that degrade this resistance as a first treatment option.

14 Oct 2024

Cell Division Variability Promotes Healthy Embryo Development

There is variability in when and how cells divide during the development of embryos. While researchers traditionally believed this variability was an obstacle that needed to be regulated, the Hiiragi group now found that it actually promotes healthy development.

14 Oct 2024

Unveiling the Protective Role of KLF6 in Diabetic Kidney Disease

Research by Stony Brook Medicine nephrology specialists may help prevent or reduce diabetic kidney disease progression by targeting cellular signaling between kidney cells and inducing a specific gene.

11 Oct 2024