Microscopy

Microscopy is an umbrella term to describe techniques used to analyse small samples that cannot be viewed with the naked eye. There is a wide range of microscopy techniques and scientific instruments available that can be used depending on their applications. A microscope magnifies tiny objects or samples and can provide a wealth of vital information about their cell structure, contamination, parasites and so much more.

This hub will contain all of the information you need to know about microscopy and will include the latest news and fascinating research articles. Whether you are looking to expand your knowledge of compound microscopes or fluorescence microscopy, you will find it all here under featured articles and the latest interviews.

What is Microscopy?

The word microscope is derived from the Greek “mikros”, meaning small and, “skopein” meaning to see.

Microscopy and Artificial Intelligence

Scanning Electron Microscopy (SEM): An Overview

Investigating the Intersection between Microscopy and Healthcare

Fluorescence Microscopy: An Overview

Using Scanning Electron Microscopy to Image SARS-CoV-2

Confocal Microscopy: An Overview

Electron Microscopy: An Overview

Using Electron Microscopy to Detect Viruses

Applications of Scanning Electron Microscopy

Uses of Microscopy in Forensics

What are Polarized Light Microscopes and How Do They Work?

See more featured articles »

Role of Microscopy in Ballistics

Applications of Polarized Light Microscopy

Phase-Contrast Microscopy: An Overview

Avoiding Cell Death in Fluorescence Microscopy

Photobleaching in Fluorescence Microscopy

TEM Imaging Modes

Visualizing the 3D Architecture of Tissues

What is Confocal Imaging?

The Determination of Post-Mortem Interval (PMI) Using Transmission Electron Microscopy

The Digital Evolution of Microscopy

What is FIB-SEM?

‘Staining’ of Biological Samples when Using Electron Microscopy: Why stain density matters

Why Size Matters in Microscopy

Light Microscopy Techniques in Virology: An Overview

Identifying Corpses Using Microscopy

What is Environmental Forensic Microscopy?

Imaging Techniques in Drug Discovery

Microscopy and Artificial Intelligence

Deep Learning in Fluorescence Microscopy

Optimizing Live Cell Imaging with FRET Microscopy

‘Staining’ of Biological Samples when Using Electron Microscopy: Why stain density matters

Applications of IVIS (In Vivo Imaging Systems)

Advances in Scanning Electron Microscopy

Microscopes in Forensic Epidemiology- An Overview

What is 3D X-Ray Microscopy?

TEM Imaging Modes

Imaging Nuclear Structures Using AFM

Advances in Fluorescence Microscopy

Cryo-Electron Microscopy: An Overview

Confocal Reflection Microscopy for Cell Migration Studies

Transmission Electron Microscopy: An Overview

How do Epifluorescence Microscopes Work?

What is High-Resolution TEM (HR-TEM)?

Applications of 3D X-ray Microscopy

Two-photon Microscopy Principles and Methodology

Advantages and Limitations of Fluorescence Microscopy

Optical Microscopy: An Overview

Light Microscopy Techniques in Virology: An Overview

Optimizing Live Cell Imaging with FRET Microscopy

Using Microscopy for Deep In Vivo Brain Imaging

Microscopy’s Involvement in Brain Imaging

Differentiating Tumors using Microscopy

Expansion Microscopy in Neurology

Scanning Helium Microscopy: An Overview

X-ray Microscopy: An Overview

Diagnosing Alzheimer's Using Microscopy

Intravital Kidney Microscopy: An Overview

Investigating the Applications of Meoscopy

What is Expansion Microscopy?

Live-Cell Imaging with Super-Resolution Microscopy

Understanding the Brain Through Electron Microscopy

How Do Spectrometer Accessories Elevate Instrument Capabilities?

Microscopy in Oncology Research: Visualizing Tumor Microenvironments

Latest Microscopy News and Research

Novel Microscopy Reveals Two-Stage T-Cell Activation During Viral Infection

The research teams led by Wolfgang Kastenmüller and Georg Gasteiger utilized advanced microscopy techniques to investigate the activation and proliferation of specific immune cells, known as T-cells, during viral infections.

11 Apr 2025

Unraveling the Interaction Between Mitochondrial Proteins HAX1 and CLPB

A recent study published in Magnetic Resonance Letters has revealed for the first time the interaction mechanism between the mitochondrial proteins HAX1 and CLPB, filling the research gap between these two key proteins in the field of structural dynamics and functional association.

10 Apr 2025

Scientists Unveil Dynamic Structure of Vision-Linked Protein RBP3

Scientists have for the first time looked deep into the protein structure that may determine our vision - and discovered that it is much more dynamic than previously thought.

8 Apr 2025

Digital Holographic Microscopy Reveals Microbial Biosignatures in Harsh Environments

New research from Portland State University focused on identifying signs of life - biosignatures - in extreme environments here on Earth.

7 Apr 2025

Scientists Capture Dynamic Process of Chromatin Remodeling in Action

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases.

7 Apr 2025

Breakthrough Ultrasound Technique Reveals Living Cells in 3D

While medical centers use ultrasound daily, so far this technology is not capable of observing body tissues at the scale of cells.

4 Apr 2025

Mapping Larger Tissue Sections Without Specialized Equipment

By creating comprehensive maps of the locations of gene expression in tissue, spatial transcriptomics technologies have made it possible to perform new types of biological assessments.

4 Apr 2025

Innovative Imaging Technique Tracks Cellular Processes with Minimal Damage

An advancement in imaging technology has the potential to revolutionize the understanding of the inner workings of living cells and offer insights into a variety of diseases.

3 Apr 2025

How Does DNA Unwind? Study Explores Helicase Mechanisms In DNA Replication

This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights into viral replication mechanisms.

28 Mar 2025

Thermo Fisher Scientific and Chan Zuckerberg Institute for Advanced Biological Imaging Collaborate to Further Understanding of Human Cells

Thermo Fisher Scientific Inc., the world leader in serving science, has announced a Technology Alliance Agreement with the Chan Zuckerberg Institute for Advanced Biological Imaging (CZ Imaging Institute).

28 Mar 2025

Unlocking CBD’s Potential with Phospholipid Tech

Research shows phospholipid complexation enhances CBD's solubility and absorption, paving the way for more effective treatments for epilepsy and chronic pain.

26 Mar 2025

Researchers Capture Breakthrough Images of Cellulose Synthesis in Living Plant Cells

In a groundbreaking study on the synthesis of cellulose – a major constituent of all plant cell walls – a team of Rutgers University-New Brunswick researchers has captured images of the microscopic process of cell-wall building continuously over 24 hours with living plant cells, providing critical insights that may lead to the development of more robust plants for increased food and lower-cost biofuels production.

24 Mar 2025

Scientists Identify Crucial Mechanism for Maintaining Neuronal Identity in the Brain

A team of researchers from the Institute for Neurosciences, a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) of Elche, in collaboration with researchers from Columbia University (New York, USA), has identified a mechanism that regulates the production of two different proteins from the same gene.

24 Mar 2025

Unraveling the Evolutionary Link to Eukaryotic Cells

A decade ago, the existence of Asgard archaea was unknown. However, in 2015, researchers analyzing deep-sea sediments uncovered gene fragments that suggested the presence of a new, previously unidentified group of microbes.

24 Mar 2025

First-Ever Molecular Movie Shows DNA Unzipping Mechanism in Action

Scientists at the University of Leicester have captured the first detailed "molecular movie" showing DNA being unzipped at the atomic level – revealing how cells begin the crucial process of copying their genetic material.

22 Mar 2025

Visualizing the Fundamental Process of DNA Strand Separation

The exact moment DNA starts to unravel has been seen by scientists for the first time, exposing a chemical process that is essential for DNA to be the molecule that codes for all life.

20 Mar 2025

Breakthrough Microscopy Sheds Light on the Dynamics of Biomolecular Condensates

Biomolecular condensates are shifting blobs in our cells that organize cellular matter. They are distinct molecular communities made of DNA, RNA and proteins that "condense" molecules to key locations, yet they frequently defy description.

17 Mar 2025

New Tool for Microscopic Temperature Mapping

At the cellular level, temperature is a crucial factor that affects innumerable biological processes. It is still difficult to measure temperatures inside living cells precisely, though.

17 Mar 2025

SRS Microscopy Unlocks New Insights into Cellular Metabolism and Disease

Cellular metabolism plays a critical role in various physiological and pathological processes. High resolution imaging of intracellular metabolic activities is crucial for understanding many biological pathways, and for facilitating disease prognosis and treatment assessment.

14 Mar 2025

Molecular Intelligence Simplifies Cryo-EM Data Analysis with AI

Scientists from Purdue University’s College of Science and the Rosen Center for Advanced Computing have established Molecular Intelligence, a software company dedicated to assisting researchers in determining the 3D structures of biomolecules captured through cryogenic-electron microscopy (cryo-EM).

13 Mar 2025