Proteomics, Metabolomics and Lipidomics

The ‘omics revolution ensued from the surge in genetic sequencing seen in the 1990s as scientists aimed to sequence the whole human genome. Advances in sequencing and analytical technologies allowed for increased efficiency and precision, and an integrated, comprehensive approach to understanding organisms followed.
This approach is termed “’omics” and includes the following fields; genomics, transcriptomics, proteomics, fluxomics, and metabolomics. These fields collectively consider all of their respective constituents.
For example, proteomics is the large-scale study of the entire complement of proteins in cell types or organisms. Unlike it’s predecessors, genomics and transcriptomics, proteomics is more complicated as it involves the consideration of post translational modifications, such as phosphorylation. Proteomics has practical applications in protein networks where the study of ways proteins interact aids the field of systems biology, the computational and mathematical analysis and modeling of complex biological systems. Proteomic technologies can be applied to high-throughput techniques, such as mass spectroscopy.
Over the last 30 years, the ’omics have received attention from the research community, the media, and the public alike, largely owing to the advances in scientific understanding that have resulted from ‘omics research. It remains an exciting and fast-paced field of study that is set to continue expanding our knowledge of biological molecules and systems.

Global Market Report: Proteomics

In this article, we discuss the applications of proteomics and its recent developments, along with reviewing the current global market and predicting how the field may evolve in the future.

Applications of Bone Proteomics

Insight into the Human Proteoform Project

Importance of Solubility and Lipophilicity in Drug Development

How Can Proteins Help Organisms to Tell the Time?

The ‘omics’ Revolution

Understanding Native Protein Characterization

How does the Proteome Differ Between Individuals?

Using Omics to Harness the Power of Personalized Nutrition

Role of Applied Omics in Precision Medicine

Metabolomics in Toxicology

Protein Degradability

See more featured articles »

Role of Proteomics in COVID-19

What is Forensic Proteomics?

Interpreting Proteomics Data

Analyzing Proteomes Using LC-MS/MS

Combating Counterfeit Green Tea with Metabolomic Profiling

What is the Metabolome?

Importance of Lipidomics in Stem Cell Research

How have Fluorescent Proteins Transformed Science?

Investigating the Evolution of Microbiome Science

The Human Metabolome Project

Combating Infectious Diseases Through Computational Protein Design

Exploring Biosynthetic Diversity

Role of Proteomic Analysis in Skin Regeneration

The Role of Metabolomics in Precision Medicine

A Beginners Guide to Plasma Proteomics

Ethics in Clinical Proteomics

How do we Radiolabel Proteins?

What is Metabolomics?

The Steps of Protein Synthesis

Protein Production: Initiation, Elongation and Termination

Compound Identification for Nontargeted Metabolomics

What is Single-Cell Proteomics?

Racial Differences in Protein Biomarkers

What is 'Bottom-Up' Proteomics?

What is Pharmacometabolomics?

What is 4D Proteomics?

Effects of Filtered Coffee on Plasma Metabolites

An Overview of Quantitative Proteomics

What is Western Blotting?

Challenges with Standardization in Lipidomics

What is Proteomics?

What is Immunoliposome Therapy?

What Role do Proteins Play in Disease?

How are the Metabolome and Proteome Related?

Omics Approaches to Biomarker Analysis

How are Advancements in Mass Spectrometry Impacting Metabolomics Research?

What are G-Protein-Coupled Receptors?

What are Prions?

Compound Identification for Nontargeted Metabolomics

Comparison Between Metabolic Target Analysis and Metabolic Profiling

Protein Biosynthesis

Discovering Misfolded Proteins using Fluorescent Probes

Quantifying Protein Diversity: Using DIA-MS to Measure Post-Translational Modifications

What is Phosphoproteomics?

Pharmacokinetics of Cannabis and its Secondary Metabolites

Liver Disease Biomarkers

What is Phenomics?

Challenges in Environmental Metabolomics

An Overview of Protein Localization

Environmental Metabolomics

Importance of Blood Serum Calorimetry in Lung Cancer Treatment

How to Analyze Macromolecular Protein Complexes

What is Clinical Proteomics?

How is Omics Revolutionizing Cancer Research?

What is Protein Ubiquitylation?

Lipidomics in Food Science

A Guide to Optimizing Protein Design

Determining Proteins in Milk Using Dumas Analysis

Eliminating American Foulbrood using Endolysins

Challenges in Metabolomic Fingerprinting

Cytometric Bead Arrays: A Breakdown of the Technique

Combining Proteomics and Genomics to Eliminate Disease

Studying the Metabolic Pathways Between Tissues

What is Shotgun Lipidomics?

Applications of Peptidomics

To the Bone: How Proteomics is Uncovering the Mysteries of Ancient DNA

Global Market Overview: Metabolomics

Understanding Neurobiology through Proteins

Heritability Differences in Metabolic Classes

Latest Proteomics, Metabolomics and Lipidomics News and Research

A Python-Inspired Molecule Suppresses Appetite After Eating

The study identifies pTOS as a key metabolite in appetite suppression, highlighting a gut–liver–brain pathway with implications for obesity therapy.

2 Apr 2026

Excessive RNA Editing May Explain Neurological Differences in Down Syndrome

A collaborative research study co-led by scientists at the Icahn School of Medicine at Mount Sinai and the Liber Institute for Brain Development has for the first time identified a biological process that may help explain how the brain develops differently in people with Down syndrome. The study was a collaboration among scientists from the Icahn School of Medicine at Mount Sinai, the Lieber Institute for Brain Development, the Medical University of Sofia in Bulgaria, and the University of Arizona.

2 Apr 2026

Researchers Use Retron Systems to License DNA for Cellular Tasks

Stepping away from its billions-of-years-old role as a genetic "blueprint," DNA is now embarking on a new journey as an active "field agent" within cells. This research by a team led by Professor Jongmin Kim and Ph.D. candidate Geonhu Lee from the Department of Life Sciences at POSTECH (Pohang University of Science and Technology) was published in the online edition of the international chemistry journal, Nature Chemistry.

2 Apr 2026

Study Reveals How Biological Machines Write New Genetic Information

New research has discovered that the molecular machines responsible for copying our DNA have a surprising hidden talent – an ability to create entirely new and highly sophisticated DNA sequences from scratch.

1 Apr 2026

New Framework Prioritizes Uncertain Genetic Variants in Cancer Profiling

Hiroshima University researchers have developed a practical framework to identify candidate pathogenic variants hidden among the large number of variants of uncertain significance (VUS) detected in comprehensive genomic profiling (CGP) of cancers.

1 Apr 2026

Cysteine Pathways Shape T Cell Expansion and Cancer Defense

A research team from the Johns Hopkins Kimmel Cancer Center, its Bloomberg~Kimmel Institute for Cancer Immunotherapy and the Johns Hopkins Bloomberg School of Public Health have discovered how the immune system's CD8+ T cells use the nutrient cysteine to control two essential functions that compete for this resource - the immune cell's ability to multiply and its ability to kill cancer cells.

1 Apr 2026

Mirror Protein Design Blocks Amyloid Beta in Alzheimer’s Disease

Understanding how proteins interact with their own mirror images enabled a Kobe University research team to design a small mirror protein that disables a causal factor of Alzheimer's disease, amyloid-beta.

1 Apr 2026

Nonviral Nanoparticles Show Promise for Safer Gene Delivery Methods

In a demonstration that helps pave the way for gene therapies with fewer side effects, several human cell types were genetically modified with protein nanoparticles designed at University of Michigan Engineering and Michigan Medicine.

1 Apr 2026

Study Reveals How Trypanosomes Fine-Tune Protein Production Through Destruction

To survive in the human bloodstream, the African trypanosome parasite wears a "cloak" made of proteins known as a variant surface glycoprotein (VSG). The study, published in Nature Microbiology, identifies the protein that allows the parasite to fine-tune this "cloak".

31 Mar 2026

Study Links ER Stress From Fat Buildup to Senescence

When cells experience enough chronic stress, they can stop dividing permanently. In this state of cellular limbo, known as replicative senescence, cells remain alive but no longer proliferate.

31 Mar 2026

Novel Immunotherapy Disrupts the Protective Tumor Microenvironment Ecosystem

Chimeric antigen receptor T-cell therapy - CAR T for short - has been a major advance in treating blood cancers like leukemia and lymphoma. But the immunotherapy has struggled against solid tumors for two main reasons: tumor cells often don't share one consistent surface target, and many solid tumors are protected by a dense network of scar tissue and immune-suppressive cells that blocks T cells.

31 Mar 2026

Sweat Peptide Dermcidin Prevents Flu Virus Entry Into Cells

A research team led by the Fisabio Foundation has demonstrated that dermcidin, an antimicrobial peptide produced constitutively by the human body, also exhibits antiviral activity against the influenza virus. The study also shows that people who do not develop flu-like symptoms have higher baseline levels of this molecule, which could be associated with lower susceptibility to infection.

31 Mar 2026

Study Highlights the Vast Untapped Potential Within the Global Protein Universe

The number of known proteins is infinitely small in comparison to the universe of possible proteins which could in theory be realized. Yet these known proteins are the only major training ground for future protein design. Understanding how representative these proteins are of the overall potential diversity can therefore help inform strategies for a wide range of applications, including therapeutic, biocatalysis, or biomaterials development.

31 Mar 2026

New Computational Tools Improve Gene Function Determination Within Fungal Organisms

While RNA sequencing (RNA-seq) has become a standard tool for profiling which genes are active in an organism, determining the actual biological functions of those genes in fungi remains a significant technical challenge. Most existing software tools are designed to cover a broad range of species, often lacking the specificity required for the unique genetic landscape of fungi.

31 Mar 2026

Identifying the Cellular Origin of MS-Related Neuroinflammation

Signals from the gut have been linked to autoimmune inflammation, but fundamental cellular processes remain poorly understood.

30 Mar 2026

Genome-Wide Screen Reveals Drivers of Ciprofloxacin Tolerance Mechanisms

Persisters are a bacterial subpopulation that exhibits tolerance to antibiotics and plays a critical role in chronic and recurrent infections.

28 Mar 2026

Fusion Protein Rewires Brain Development to Trigger Pediatric Cancer

A team of researchers at Baylor College of Medicine, St. Jude Children's Research Hospital, Texas Children's Hospital and collaborating institutions reveal in the journal Nature a novel mechanism that drives the development of pediatric supratentorial ependymoma (EPN), the third most common pediatric brain tumor.

28 Mar 2026

Study Reveals How STING Protein Migrates to Trigger Immune Responses

UT Southwestern Medical Center researchers have identified how the quintessential immune protein known as stimulator of interferon genes (STING) migrates from one cellular organelle to another, a necessary step in its activation.

27 Mar 2026

Microtubules Act as Active Regulators of Key Cellular Enzymatic Reactions

Microtubules, the dynamic filaments that form the cell's internal scaffolding, have long been viewed as mere passive structural supports. But a new study reveals they play a far more active signaling role.

27 Mar 2026

Newly Discovered CRISPR System Activates Genes Without Cutting DNA

In back-to-back studies published in Nature, researchers from Purdue University and Columbia University report a naturally evolved gene-editing system that can activate genes, offering an advantage over existing CRISPR gene-editing systems that merely find and cut DNA.

26 Mar 2026