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5-ALA Opens New Avenues for Treating Mitochondrial Disorders

At the Tokyo Metropolitan University, researchers have shown that 5-aminolevulinic acid (5-ALA) aids bypass deficiencies in Complex I (CI), the first in a series of protein complexes that transport electrons and assist in powering the mitochondria.

17 Jul 2023

New Insights into the Regulatory Network of Th17 Cells

N6-methyladenosine (m6A) is the most extensively studied RNA modification across multiple species, and its importance in the immune system has been demonstrated in a variety of contexts, including mRNA metabolism, cell differentiation, proliferation, and response to stimulation.

17 Jul 2023

Research Reveals How Living Matter Can Be Reproduced on a Cellular Scale

A team of scientists has devised a system that replicates the movement of naturally occurring phenomena, such as hurricanes and algae, using laser beams and the spinning of microscopic rotors.

14 Jul 2023

Scientists Develop New Method to Grow Mycocrete Using Fungi and Knitted Molds

Scientists hoping to reduce the environmental impact of the construction industry have developed a way to grow building materials using knitted molds and the root network of fungi. Although researchers have experimented with similar composites before, the shape and growth constraints of the organic material have made it hard to develop diverse applications that fulfil its potential.

14 Jul 2023

New Toxin Found to Enhance Pathogen Infection and Disease Spread in Wheat

Although wheat was among the first domesticated food crops, it remains a global dietary staple several millennia later.

14 Jul 2023

Extrusion-Mediated Self-Renewal: A New Way for Kidney Cells to Stay Healthy

University of Texas at Dallas scientists have discovered a previously unknown "housekeeping" process in kidney cells that ejects unwanted content, resulting in cells that rejuvenate themselves and remain functioning and healthy.

14 Jul 2023

New Simulations Reveal How Nuclear Pore Complex Regulates Protein Trafficking

If the human cell is a nightclub, then the nucleus is a VIP lounge. Inside are the DNA, fiercely maintained by the nuclear pore complex, which is charged with the task of protecting every strand. To do this, the NPC acts as gatekeeper against unworthy proteins.

14 Jul 2023

Rensselaer Professor Receives $400,000 Grant to Study Deep Sea Enzymes

Rensselaer Polytechnic Institute's Catherine Royer, Constellation Chair Professor of Bioinformatics and Biocomputation at the Shirley Ann Jackson, Ph.D. Center for Biotechnology and Interdisciplinary Studies (CBIS) and professor of biological sciences, has received a grant of over $400,000 from the National Science Foundation to investigate enzymes from organisms living in deep sea environments.

14 Jul 2023

New P38 Inhibitors Selectively Target Cardiac Cell Death

The p38 protein regulates a wide variety of cellular functions and is related to diseases such as chronic inflammation, immunological disorders, or cancer.

14 Jul 2023

Xenogeneic-Free Brain Organoids Offer New Hope for Studying Neurodegenerative Diseases

Researchers at University of Michigan developed a method to produce artificially grown miniature brains -; called human brain organoids -; free of animal cells that could greatly improve the way neurodegenerative conditions are studied and, eventually, treated.

14 Jul 2023

AI-Powered Collaboration Aims to Transform Drug Development

Critical Path Institute (C-Path), a leading global nonprofit committed to expediting drug development through the acceleration of regulatory-endorsed solutions, today announced a newly formalized Memorandum of Understanding (MOU) with Vivpro, an industry-leading provider of a revolutionary biointelligence software platform and innovative services.

14 Jul 2023

Using CRISPR to Improve Forest Resilience and Productivity

Researchers at North Carolina State University used a CRISPR gene-editing system to breed poplar trees with reduced levels of lignin, the major barrier to sustainable production of wood fibers, while improving their wood properties.

14 Jul 2023

Metabolic Systems Share Previously Unknown Universal Properties: Study

A team from the University of Tokyo has combined economic theory with biology to understand how natural systems respond to change. The researchers noticed a similarity between consumers' shopping behavior and the behavior of metabolic systems, which convert food into energy in our bodies. The team focused on predicting how different metabolic systems might respond to environmental change by using an economic tool called the Slutsky equation.

14 Jul 2023

Scientists Discover How Brain's "Population Clock" Guides Behavior

From Aristotle's musings on the nature of time to Einstein's theory of relativity, humanity has long pondered: how do we perceive and understand time? The theory of relativity posits that time can stretch and contract, a phenomenon known as time dilation. Just as the cosmos warps time, our neural circuits can stretch and compress our subjective experience of time. As Einstein famously quipped, "Put your hand on a hot stove for a minute, and it seems like an hour. Sit with a pretty girl for an hour, and it seems like a minute".

14 Jul 2023

Scientists Identify "Footprints" of Participation Bias in Genetic Data

Why do some people take part in genetic studies while others do not? The answer may lie within our genetic makeup. According to a groundbreaking study by Oxford's Leverhulme Centre for Demographic Science and Big Data Institute, people who participate in genetic studies are genetically more likely to do so, leaving detectable 'footprints' in genetics data. This breakthrough equips researchers with the ability to identify and address participation bias, a significant challenge in genetic research.

14 Jul 2023

New Study Shows How Butterflies and Moths Can Help Understand Evolution

Butterflies and moths share "blocks" of DNA dating back more than 200 million years, new research shows.

14 Jul 2023

Novel Drug Compound Reduces Sensory Hypersensitivity in Fragile X Mice

Boosting the activity of inhibitory interneurons in Fragile X mice reduced their hypersensitivity to sensory stimuli, according to a new Neuron study led by UCLA Health researchers.

14 Jul 2023

Revealing the Function of Retrotransposons

A retrotransposon, a parasitic DNA sequence that borrows the cell’s own machinery to accomplish its objectives, has been discovered.

13 Jul 2023

Mast Cells May Help Humans Avoid Harmful Antigens

Mast cells, which are part of the immune system, are still a puzzle. Mast cells function as a sensor that signifies the animals to avert antigens, including harmful allergens, and thus safeguard themselves from health-threatening inflammatory reactions, according to researchers at the German Cancer Research Center (DKFZ). The research was published in the journal Nature.

13 Jul 2023