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New mouse line reveals the state of proteostasis in mammalian brain for the first time

Proteins are the "tools" of our cells – they are essential to all vital tasks. However, they are only able to do their jobs if they fold correctly and adopt their respective, very specific 3D structure.

20 Aug 2021

Restoring cholesterol levels could be a new therapeutic approach for neurodegenerative diseases

Scientists have found that the brain lacks the ability to maintain the cholesterol-rich myelin sheath that insulates neurons when a protein is absent.

From National University of Singapore (NUS) 10 Aug 2021

Largest study identifies causal genetic variants associated with type 1 diabetes risk

Scientists have completed the largest and most diverse genetic study of type 1 diabetes ever undertaken, identifying new drug targets to treat a condition that affects 1.3 million American adults.

23 Jul 2021

Study reveals neurotransmitter releases impairments in schizophrenia patients

A research team revealed that neurotransmitter release in the brain is impaired in patients with schizophrenia who possess a rare, single-gene mutation.

16 Jul 2021

Isoflavone diet plus metabolizing gut bacteria may provide protection against MS

A new University of Iowa study suggests that metabolism of plant-based dietary substances by specific gut bacteria, which are lacking in patients with multiple sclerosis (MS), may provide protection against the disease.

14 Jul 2021

Mass spectrometry: Important analytical tool to understand Huntington’s disease proteome

Mass spectrometry has emerged as an important analytical tool for gaining a better understanding of mechanisms underlying Huntington's disease (HD), alongside the increased availability of cell and animal models of the disease.

14 Jul 2021

Study reveals the relationship between gut microbiome and neurodegenerative disorders

Eran Blacher bagged the NOSTER & Science Microbiome Prize 2021 for his work in highlighting the relationship between the microbiome and neurodegenerative diseases.

12 Jul 2021

World’s first cancer cell model helps modern cancer research and drug development

For many years, computer models have been standard tools in fundamental biomedical research.

5 Jul 2021

Western high-fat diet can increase the risk of painful conditions

A typical Western high-fat diet can increase the risk of painful disorders common in people with conditions such as diabetes or obesity, according to a groundbreaking paper authored by a team led by The University of Texas Health Science Center at San Antonio, also referred to as UT Health San Antonio.

24 Jun 2021

Fluorescence microscopy and deep learning predict viral infections

Researchers have now used fluorescence images from live cells to train an artificial neural network to reliably detect cells that are infected by herpes viruses.

22 Jun 2021

New types of glial cells in the brain may treat neurodegenerative diseases

Researchers from the University of Basel have discovered two types of glial cells that may play an important role in brain plasticity and repair.

15 Jun 2021

Study finds a link between progression of Alzheimer’s disease and corpuscles in cell nuclei

Studies conducted on patients’ tissue as well as mini-brains created from stem cells have provided a better insight into Alzheimer’s disease.

15 Jun 2021

Single biomarker in the blood can accurately indicate underlying neurodegeneration

Levels of a protein called neurofilament light chain (NfL) in the blood can identify those who might have neurodegenerative diseases such as Down's syndrome dementia, motor neuron disease (ALS) and frontotemporal dementia, when clinical symptoms are not definitive.

8 Jun 2021

News study may lead to future therapeutic strategies against obesity, diabetes

The gut and the brain communicate with each other in order to adapt satiety and blood sugar levels during food consumption. The vagus nerve is an important communicator between these two organs.

3 Jun 2021

Mouse model reveals new insights about amyotrophic lateral sclerosis

ALS is a very severe neurodegenerative disease in which nerve cells in the spinal cord controlling muscles and movement slowly die.

2 Jun 2021

New study shows why some children get secondary leukemia after neuroblastoma treatment

Researchers from the Wellcome Sanger Institute and the University of Cambridge discovered that in children with neuroblastoma—a tumor of immature nerve cells—platinum chemotherapy created mutations in the genome that might lead to leukemia in some children later on.

31 May 2021

Light-controlled on/off switch can help reset the biological clock

The biological clock is present in almost all cells of an organism. As more and more evidence emerges that clocks in certain organs could be out of sync, there is a need to investigate and reset these clocks locally.

26 May 2021

Researchers suggest new strategies for finding drugs that neutralize key enzymes

Scientists from the UK's University of Bath explore racemases - an important type of enzyme that is linked to certain cancers and other life-threatening diseases while also being critical to cell function - in a paper published in the prestigious journal Chemical Society Reviews. The scientists also propose new strategies for finding drugs that neutralize these enzymes.

From University of Bath 26 May 2021

Researchers gain new insights into the physiological functions of APP protein

The pivotal role played by the APP protein in Alzheimer’s disease is well known.

20 May 2021

Study: Individuals who recovered from depression had increased level of serotonin transporter

Low levels of serotonin in the brain are seen as a possible cause of depression and many antidepressants act by blocking a protein that transports serotonin away from the nerve cells.

11 May 2021