Inflammation News and Research

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Blunted inflammatory response could make obese patients more susceptible to severe COVID-19

Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists.

21 Mar 2023

Uncovering the role of the third intracellular loop in the GPCR’s signaling mechanism

Over a one-third of FDA-approved drugs tend to function by targeting a G protein-coupled receptor, or so-called GPCR. The human body consists of over 800 kinds of GPCRs that offer cells with data concerning the external surrounding to calibrate responses.

20 Mar 2023

Study discovers the ability of certain blood immune cells to proliferate

The ability of a cell to divide, to proliferate, is essential for life and gives rise to the formation of complex organisms from a single cell.

20 Mar 2023

Researchers uncover the role of third intracellular loop in GPCR's signaling mechanism

More than a third of FDA-approved drugs work by targeting a G protein-coupled receptor, or GPCR. The human body has more than 800 types of GPCRs that provide cells with information about the external environment to calibrate responses.

20 Mar 2023

Potential approach to improve solid tumor T cell therapy

Researchers at the Perelman School of Medicine at the University of Pennsylvania have been working on a preclinical study that focuses on a new strategy that uses a “one-two punch” to assist T cells in attacking solid tumors.

17 Mar 2023

Study examines the role of dietary vitamin A in preventing or treating AAP

Consuming a diet rich in vitamin A or its analogs may help prevent children and young adults with acute lymphoblastic leukemia (ALL) reduce their risk of developing painful pancreas inflammation during chemotherapy treatment.

16 Mar 2023

Gut microbiome may modulate the efficacy of CAR-T cell cancer immunotherapy

Scientists from German Cancer Research Center (DKFZ), together with colleagues from Germany, Israel, and the USA, have found that the gut microbiome may modulate the efficacy of CAR-T cellular immunotherapy CAR-T cells in patients with B cell lymphomas.

14 Mar 2023

Investigating the potential cellular effects of C-reactive protein

The biological function of the C-reactive protein, CRP, has long been unidentified. Investigators at LiU have discovered that this protein has a useful function in the inflammatory disease systemic lupus erythematosus or SLE.

10 Mar 2023

Olive oil by-products could have antioxidant benefits

New research has found that a natural by-product of olive oil production could potentially have antioxidant benefits and support exercise.

10 Mar 2023

Scientists shed new light on aging processes in the brain

Scientists from the Trinity Biomedical Sciences Institute (TBSI) have shed new light on aging processes in the brain.

9 Mar 2023

Study shows link between a mitochondrial metabolite and activation of inflammatory response

A new study shows for the first time a connection between a mitochondrial metabolite and the activation of an inflammatory response.

9 Mar 2023

Pentamer shape of C-reactive protein can suppress the immune response in inflammatory disease

The biological function of the C-reactive protein, CRP, has long been unknown. Researchers at Linköping University in Sweden now show that this protein has a beneficial function in systemic lupus erythematosus, SLE, an inflammatory disease.

9 Mar 2023

Study pinpoints a splicing deregulation that causes therapeutic vulnerability in pediatric AML

Pediatric acute myeloid leukemia or pAML is a childhood blood cancer, one that has proved confounding to clinicians and researchers, with a high relapse rate and relatively few identified genetic mutations (compared to the adult version) that might explain its cause.

8 Mar 2023

Researchers track a specialized garbage disposal cell inside lymph nodes for the first time

For almost 140 years, the origin and behavior of an enigmatic cell type inside lymph nodes, called a tingible body macrophage, has remained a mystery.

3 Mar 2023

Using nanoparticles to carry drugs across the blood-brain barrier

Brain tumors are notoriously hard to treat. One reason is the challenge posed by the blood-brain barrier, a network of blood vessels and tissue with closely spaced cells.

3 Mar 2023

Regulatory T cells produced in the gut play a role in repairing injured muscles

The human immune system is incredibly versatile. Among its most skilled multitaskers are T cells, known for their role in everything from fighting infection to reining in inflammation to killing nascent tumors.

3 Mar 2023

Cell therapy trial promises long-term improvement for patients with chronic heart failure

Physician-scientists at The Texas Heart Institute announced today the results of the largest cell therapy trial to date in patients with chronic heart failure due to low ejection fraction.

28 Feb 2023

New molecular understanding of how head injury may contribute to glioma risk

Researchers from the UCL Cancer Institute have provided important molecular understanding of how injury may contribute to the development of a relatively rare but often aggressive form of brain tumor called a glioma.

27 Feb 2023

Insilico Medicine: IND application for first generative AI-designed drug for COVID-19 approved

Insilico Medicine, a clinical-stage biotech company powered by generative AI, today announces that China National Medical Products Administration (NMPA) has approved the Investigational New Drug (IND) application for ISM3312, an orally available 3CLpro inhibitor generated and designed with the support of Insilico's proprietary generative chemistry platform Chemistry42 for the treatment of COVID-19.

24 Feb 2023

Discovery of a lung stem cell subset provides opportunity for new COPD treatments

Respiratory viral infections pose significant morbidity and mortality to patients with chronic lung diseases like emphysema and COPD, causing exacerbations that drive destruction of normal lung tissue, and leading to one of the most common diagnoses for hospital admissions.

24 Feb 2023

Inflammation News and Research

Blunted inflammatory response could make obese patients more susceptible to severe COVID-19

Uncovering the role of the third intracellular loop in the GPCR’s signaling mechanism

Study discovers the ability of certain blood immune cells to proliferate

Researchers uncover the role of third intracellular loop in GPCR's signaling mechanism

Potential approach to improve solid tumor T cell therapy

Study examines the role of dietary vitamin A in preventing or treating AAP

Gut microbiome may modulate the efficacy of CAR-T cell cancer immunotherapy

Investigating the potential cellular effects of C-reactive protein

Olive oil by-products could have antioxidant benefits

Scientists shed new light on aging processes in the brain

Study shows link between a mitochondrial metabolite and activation of inflammatory response

Pentamer shape of C-reactive protein can suppress the immune response in inflammatory disease

Study pinpoints a splicing deregulation that causes therapeutic vulnerability in pediatric AML

Researchers track a specialized garbage disposal cell inside lymph nodes for the first time

Using nanoparticles to carry drugs across the blood-brain barrier

Regulatory T cells produced in the gut play a role in repairing injured muscles

Cell therapy trial promises long-term improvement for patients with chronic heart failure

New molecular understanding of how head injury may contribute to glioma risk

Insilico Medicine: IND application for first generative AI-designed drug for COVID-19 approved

Discovery of a lung stem cell subset provides opportunity for new COPD treatments

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