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Stem cells that promote bone repair can also generate arthritic bone spurs

The same stem cells that heal broken bones can also generate arthritic bone spurs called osteophytes, according to a new study in the Annals of the Rheumatic Diseases.

13 Oct 2020

Dopamine and serotonin found to be involved in perception, cognitive capacities

In first-of-their-kind observations in the human brain, an international team of researchers has revealed two well-known neurochemicals -- dopamine and serotonin -- are at work at sub-second speeds to shape how people perceive the world and take action based on their perception.

13 Oct 2020

Researchers trace neurons in mosquitoes that sense blood's distinctive flavor

It's one of the world's deadliest animals, and it has a taste for human blood: the mosquito. Mosquitoes spread diseases like malaria, dengue, and yellow fever that kill at least a half a million people each year. Now researchers are learning what humans taste like to mosquitoes, down to the individual neurons that sense blood's distinctive, delectable flavor.

13 Oct 2020

Enzyme SSH1 impairs disposal of damaged tau and mitochondria leaking toxins

In a healthy brain, the multistep waste clearance process known as autophagy routinely removes and degrades damaged cell components - including malformed proteins like tau and toxic mitochondria.

13 Oct 2020

Severe cases of COVID-19 resemble systemic lupus erythematosus

Scientists from Emory Health Sciences have been observing an intense stimulation of immune cells in severe cases of COVID-19 disease. This activation of immune cells is similar to acute flares of systemic lupus erythematosus (SLE)—an autoimmune disease.

13 Oct 2020

Oncopig fulfills the unmet clinical modeling needs for hepatocellular carcinoma

Volume 11, Issue 28 of Oncotarget features "Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation" by Gaba et, al. which reported that reliable development of Oncopig HCC cell lines was demonstrated through hepatocyte isolation and Cre recombinase exposure across 15 Oncopigs.

12 Oct 2020

Researchers test the effect of hydroxychloroquine versus favipiravir in SARS-CoV-2−infected hamsters

Virologists at the KU Leuven Rega Institute have been working on two lines of SARS-CoV-2 research: searching for a vaccine to prevent infection, and testing existing drugs to see which one can reduce the amount of virus in infected people.

12 Oct 2020

Developing a 'Trojan Horse' nanotherapy to fight breast cancer

With a nearly $2.6 million grant from the National Institutes of Health, Michigan State University researchers are using nanoscopic particles to turn the body's own cells into weapons that cancer won't see coming.

12 Oct 2020

Bone destruction caused by too little sugar

Bone marrow cancer is currently an incurable disease that affects about 400 people in Norway every year. Professor Therese Standal at NTNU has now found an important reason for bone destruction in people with this disease.

12 Oct 2020

New radioimmunotherapy effectively reverses resistance to lymphoma therapy

A new radioimmunotherapy has proven effective in reversing resistance to the most commonly used lymphoma drug, rituximab, according to research published in the October issue of The Journal of Nuclear Medicine.

9 Oct 2020

New approach to determine the structure of large RNA molecules

Researchers have designed a new technique to establish the structures of huge RNA molecules at high resolution.

9 Oct 2020

Researchers identify specific neurons that may contribute to epileptic seizures

Epilepsy, results from impairment in brain cells and is often treated with drugs that counteract or control the seizures.

9 Oct 2020

Immune cell biomarker may help identify patients at risk for graft-versus-host disease

A recent report published in Science Translational Medicine by MUSC Hollings Cancer Center investigator Sophie Paczesny, M.D., Ph.D., sheds light on immune cell biomarkers that may reveal which patients are most at risk for graft-versus-host disease (GVHD), a life-threatening condition that can arise after hematopoietic stem cell transplantation (HSCT) for treatment of liquid cancers such as leukemia.

8 Oct 2020