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UConn Health scientists explain why Shigella bacteria can infect humans but not mice

Shigella bacteria can infect humans but not mice. In the March 29 issue of Nature, a team from UConn Health explains why. Their findings may explain the multifariousness of a key weapon of our immune system.

31 Mar 2023

Revealing the structural basis underpinning the biophysical properties of pili

According to the World Health Organization, enterotoxigenic Escherichia coli (ETEC) bacteria are the most common cause of traveler’s diarrhea and cause the greatest number of known community-acquired cases of childhood diarrhea in the developing world.

31 Mar 2023

Previously unknown telomere and cancer connection to the immune system revealed

Johns Hopkins Medicine scientists say their 20-year study of more than 200 people with premature aging syndromes caused by abnormally short telomeres, or shortened repetitive DNA sequences at the ends of chromosomes, may upend long-held scientific dogma and settle conflicting studies about how and whether short telomeres contribute to cancer risk.

31 Mar 2023

Ancient DNA reveals African founders intermingled with southwest Asian people around 1000 CE

While serfs toiled and knights jousted in Europe and samurai and shoguns rose to power in Japan, the medieval peoples of the Swahili civilization on the coast of East Africa lived in multicultural, coral-stone towns and engaged in trade networks spanning the Indian Ocean.

30 Mar 2023

Study expands understanding of PAK1-related IDDMSSD

A recent study from Texas Children's Hospital and Baylor College of Medicine has expanded the clinical spectrum of a new epileptic disorder called Intellectual Developmental Disorder with Macrocephaly, Seizures, and Speech Delay (IDDMSSD) with the identification of the first recurrently affected residue identified in the protein kinase domain of PAK1 protein.

30 Mar 2023

No more needles? Future vaccines could be delivered by a puff of air

In the future, vaccines may be delivered with a puff of air rather than a needle, according to the promising results of new research presented at a meeting of the American Chemistry Society this March.

27 Mar 2023

New findings could help target the causes of aging and cancer development

A protein complex prevents the repair of genome damage in human cells, in mice and in the nematode Caenorhabditis elegans, a team of researchers at the University of Cologne has discovered.

24 Mar 2023

Generating functional patient-specific thymic organoids from human pluripotent stem cells

Researchers have used pluripotent stem cells to make thymus organoids that support the development of patient-specific T-cells, researchers report March 23rd in the journal Stem Cell Reports.

24 Mar 2023

Blunted inflammatory response in obese individuals responsible for susceptibility to severe COVID-19

Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists.

23 Mar 2023

Inaugural college and career program for oncology, hematology patients helps 'unlock' their future

On Thursday, March 2, 42 teens and young adults, all patients in the Adolescent and Young Adult Oncology Program (AYA), attended “Unlock Your Future,” the inaugural college and career program for oncology and hematology patients.

21 Mar 2023

Blunted inflammatory response could make obese patients more susceptible to severe COVID-19

Individuals who are obese may be more susceptible to severe COVID-19 because of a poorer inflammatory immune response, say Cambridge scientists.

21 Mar 2023

Unique region of the brain's cortex used when visually navigating an area by foot

Using vision to efficiently move through an area by foot uses a unique region of the brain's cortex, according to a small study funded by the National Eye Institute.

16 Mar 2023

Study reveals: Coronaviruses that cause common colds boost immune response to COVID-19

During the pandemic, it became clear that children who contracted COVID-19 became less ill than adults. One hypothesis has been that common colds would give children immunity protecting against a severe form of the disease. Researchers at Karolinska Institutet are now able to show that OC43, one of the coronaviruses that cause common colds, boosts the immune response to COVID-19. The study, which is published in PNAS, could give rise to more tailored vaccine programmes for children and adults.

16 Mar 2023

Study reveals the cellular composition and circuit organization of the locus coeruleus

A small nucleus in the brainstem called locus coeruleus (literally the "blue spot,") is the primary source of a major neuromodulator, norepinephrine (NE), an important mediator of the 'fight or flight' response in animals. However, very little is known about the local connections of this small albeit critically important group of neurons.

16 Mar 2023

Artificial pancreas helps improve blood sugar control in children with type 1 diabetes

An artificial pancreas originally developed at the University of Virginia Center for Diabetes Technology improves blood sugar control in children ages 2 to 6 with type 1 diabetes, according to a new study.

16 Mar 2023

Study examines the role of dietary vitamin A in preventing or treating AAP

Consuming a diet rich in vitamin A or its analogs may help prevent children and young adults with acute lymphoblastic leukemia (ALL) reduce their risk of developing painful pancreas inflammation during chemotherapy treatment.

16 Mar 2023

Age-related sarcopenia prevented by AAV1.NT-3 gene therapy

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, "AAV1.NT-3 gene therapy prevents age-related sarcopenia."

16 Mar 2023

Aston University receives funding for the development of a diagnostic tool for children with brain tumors

Birmingham based charity, Help Harry Help Others and Aston University researchers, are working together to develop a pioneering pre-surgical diagnostic tool, which could see the eventual outcome of children with brain tumors drastically improve.

15 Mar 2023

Study reveals the detrimental effects of even a few extra pounds on young people

A Kaiser Permanente study of more than 800,000 young people between the ages of 3 and 17 showed that youth at the upper range of average weight had a 26% higher risk of developing hypertension than those closer to what is considered average weight. The study was published March 14, 2023, in JAMA Network Open.

15 Mar 2023

Study shows mothers provide necessary microbes to babies born via cesarean

Can newborns delivered by cesarean surgery lack vital microbes? Recent data suggests that “no” could be the answer. Mothers are able to transmit bacteria to their babies through alternative, compensating channels, according to research published in the journal Cell Host & Microbe on March 8th, 2023.

10 Mar 2023

Children News and Research

UConn Health scientists explain why Shigella bacteria can infect humans but not mice

Revealing the structural basis underpinning the biophysical properties of pili

Previously unknown telomere and cancer connection to the immune system revealed

Ancient DNA reveals African founders intermingled with southwest Asian people around 1000 CE

Study expands understanding of PAK1-related IDDMSSD

No more needles? Future vaccines could be delivered by a puff of air

New findings could help target the causes of aging and cancer development

Generating functional patient-specific thymic organoids from human pluripotent stem cells

Blunted inflammatory response in obese individuals responsible for susceptibility to severe COVID-19

Inaugural college and career program for oncology, hematology patients helps 'unlock' their future

Blunted inflammatory response could make obese patients more susceptible to severe COVID-19

Unique region of the brain's cortex used when visually navigating an area by foot

Study reveals: Coronaviruses that cause common colds boost immune response to COVID-19

Study reveals the cellular composition and circuit organization of the locus coeruleus

Artificial pancreas helps improve blood sugar control in children with type 1 diabetes

Study examines the role of dietary vitamin A in preventing or treating AAP

Age-related sarcopenia prevented by AAV1.NT-3 gene therapy

Aston University receives funding for the development of a diagnostic tool for children with brain tumors

Study reveals the detrimental effects of even a few extra pounds on young people

Study shows mothers provide necessary microbes to babies born via cesarean

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