Preclinical News and Research

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Study indicates a powerful treatment for pulmonary fibrosis

A pre-clinical study led by scientists at Cincinnati Children's demonstrates that in mice the drug barasertib reverses the activation of fibroblasts that cause dangerous scar tissue to build up in the lungs of people with idiopathic pulmonary fibrosis (IPF).

7 Aug 2020

Researchers develop new models to study molecular characteristics of lung and pancreatic cancers

Scientists at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) report today the development of new models to study molecular characteristics of tumors of the lung and pancreas.

5 Aug 2020

Old part of immune system may influence severity of COVID-19

One of the immune system's oldest branches may be influencing the severity of COVID disease, according to a new study from researchers.

4 Aug 2020

Researchers develop CAR-T cell therapy based on TCR signal transduction

The T cell receptor (TCR) is a key receptor that is responsible for detecting tumor antigens in T cells.

4 Aug 2020

A new cell-based gene therapy approach to correct hemophilia A

In a new study from the Wake Forest Institute for Regenerative Medicine (WFIRM) researchers have developed an optimized cellular platform for delivering Factor 8 to better treat patients with hemophilia A.

29 Jul 2020

Specific protein found at high levels in the blood of people with early signs of Alzheimer's

Two decades or more before symptoms arise, plaques of a sticky protein called amyloid begin forming in the brains of people later diagnosed with Alzheimer's disease.

29 Jul 2020

Experimental mRNA-based vaccine protects animals against SARS-CoV-2

An experimental messenger RNA (mRNA)-based vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits protective immune responses in mice and non-human primates, researchers report on July 23rd in the journal Cell.

27 Jul 2020

Study reveals the role of embryonic stem cells in cell repair

Chaperone-mediated autophagy (CMA) is a self-eating process that occurs in embryonic stem cells.

27 Jul 2020

Study shows efficacy of L-Grb2 in preclinical models of ovarian and uterine cancer

The cover for issue 29 of Oncotarget features Figure 5, "In vivo effects of treatment with L-Grb2 in combination with anti-angiogenic therapy in an ovarian tumor model," by Lara, et al. which reported that adaptor proteins such as growth factor receptor-bound protein-2 play important roles in cancer cell signaling.

23 Jul 2020

New startup launched to overcome the challenge of delivering next-generation therapeutics

Harvard University's Office of Technology Development (OTD) and the Harvard T.H. Chan School of Public Health today announced the launch of Vesigen Therapeutics, a startup company that aims to overcome the challenge of delivering next-generation therapeutics, such as gene-editing complexes, RNA molecules, and other large proteins, to intracellular targets in specific tissues of interest.

23 Jul 2020

Study shows how T cells become cancer-killing cells

Within the immune system, the T lymphocytes operate to kill cancer cells or infected cells.

21 Jul 2020

Josep Carreras Institute creates spin-off to develop CAR-T based therapies for leukemia

The Josep Carreras Leukaemia Research Institute, a public centre pertaining to the Generalitat de Catalunya's (Government of Catalonia) CERCA network, has created the OneChain Immunotherapeutics spin-off, the aim of which is to develop new immuno-oncological therapeutic tools with various preclinical candidates, based on CAR-T technology for different tumors, such as cortical T-cell acute lymphoblastic leukemia (coT-ALL), a rare subtype of leukemia that mainly affects children, and which has a poor prognosis.

21 Jul 2020

New radiopharmaceutical offers precise diagnosis and treatment of prostate cancer in preclinical studies

Researchers have developed a new pair of agents that show exceptional effectiveness for precision diagnosis and treatment of prostate cancer in preclinical studies.

14 Jul 2020

PET reveals the existence of inter-organ communication between the heart and kidneys after heart attack

Whole body positron emission tomography (PET) has, for the first time, illustrated the existence of inter-organ communication between the heart and kidneys via the immune system following acute myocardial infarction, or heart attack.

14 Jul 2020

Less addictive opioid may have the ability to slow progression of osteoarthritis

A novel preclinical study by Keck Medicine of USC researchers, published in Arthritis & Rheumatology, reveals that a potential new opioid medication may have the ability to slow the progression of osteoarthritis while being less addictive than commonly prescribed opioid drugs.

14 Jul 2020

Altimmune reports positive results on intranasal COVID-19 vaccine candidate

Altimmune, Inc., a clinical-stage biopharmaceutical company, has announced positive results from the preclinical studies conducted in mice at the University of Alabama at Birmingham of its intranasal COVID-19 vaccine candidate, AdCOVID.

14 Jul 2020

Researchers discover promising drug candidate for treatment of brain disorders

Researchers at IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology) discovered a novel chemical compound, which has the potential to became a new drug for the treatment of core symptoms of brain disorders like Down syndrome and autism.

13 Jul 2020

New start-up to exploit novel drug-transporting technology

Researchers from IRB Barcelona, the University of Barcelona (UB) and the Sant Joan de Déu Research Institute - Hospital Sant Joan de Déu (SJD) have set up Gate2Brain, a company based on a novel technology developed at IRB Barcelona to transport drugs into the brain.

10 Jul 2020

Long-term culture of human pancreatic slices as a model to study regeneration of beta cells

Scientists from the Diabetes Research Institute at the University of Miami Miller School of Medicine have developed a method allowing for the long-term culture of "pancreatic slices" to study the regeneration of the human pancreas in real time.

2 Jul 2020

Research unravels molecular circuitry that controls cancer growth and spread

Research led by Queen Mary University of London has revealed novel insights into the molecular circuitry controlling cancer cell growth and spread. The findings highlight new pathways involved in these key processes of cancer progression that may represent targets for therapies.

24 Jun 2020

Preclinical News and Research

Study indicates a powerful treatment for pulmonary fibrosis

Researchers develop new models to study molecular characteristics of lung and pancreatic cancers

Old part of immune system may influence severity of COVID-19

Researchers develop CAR-T cell therapy based on TCR signal transduction

A new cell-based gene therapy approach to correct hemophilia A

Specific protein found at high levels in the blood of people with early signs of Alzheimer's

Experimental mRNA-based vaccine protects animals against SARS-CoV-2

Study reveals the role of embryonic stem cells in cell repair

Study shows efficacy of L-Grb2 in preclinical models of ovarian and uterine cancer

New startup launched to overcome the challenge of delivering next-generation therapeutics

Study shows how T cells become cancer-killing cells

Josep Carreras Institute creates spin-off to develop CAR-T based therapies for leukemia

New radiopharmaceutical offers precise diagnosis and treatment of prostate cancer in preclinical studies

PET reveals the existence of inter-organ communication between the heart and kidneys after heart attack

Less addictive opioid may have the ability to slow progression of osteoarthritis

Altimmune reports positive results on intranasal COVID-19 vaccine candidate

Researchers discover promising drug candidate for treatment of brain disorders

New start-up to exploit novel drug-transporting technology

Long-term culture of human pancreatic slices as a model to study regeneration of beta cells

Research unravels molecular circuitry that controls cancer growth and spread

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