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Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Knocking out a protein known to stifle T cell activation on CAR T cells using the CRISPR/Cas9 technology enhanced the engineered T cells' ability to eliminate blood cancers, according to new preclinical data from researchers in the Perelman School of Medicine at the University of Pennsylvania and Penn's Abramson Cancer Center.

8 Dec 2020

Researchers develop new tool to study genes associated with autism spectrum disorder

Researchers have developed technology to analyze the function of different types of genes found in many types of cells in a living organism, at the same time.

1 Dec 2020

First functional analysis of cytokine IL-15L using rainbow trout

The cytokine family including interleukin-2 and -15 (IL-2 and IL-15) started out in a primitive vertebrate species with three related cytokines IL-2, IL-15, and IL-15-like (IL-15L), all sharing binding capacity for receptor chain IL-15Rα. IL-15L was conserved in fishes, reptiles, and some mammals but lost in humans and mice.

23 Nov 2020

Gaining new insights into bacterial pneumonia

Jacqueline Kimmey speaks to AZoLifeSciences about her research into bacterial pneumonia and the genes that drive its spread from the lungs into the blood.

From University of California Santa Cruz 23 Nov 2020

Astrocytes regulate inhibitory synapses by binding to neurons

In the orchestra of the brain, the firing of each neuron is controlled by two notes--excitatory and inhibitory-- that come from two distinct forms of a cellular structure called synapses.

16 Nov 2020

Discovering a new step in immune cell generation

In this interview, Dr. Shalin Naik speaks to AZoLifeSciences about his team's latest research that led to the discovery of a new step in the development of T and B cells that could help us to better understand leukemia.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 12 Nov 2020

Dietary induction of hepatocyte regeneration could help enhance gene repair in the liver

The thyroid hormone used to promote the proliferation of hepatocytes improved the efficiency of CRISPR/Cas9-mediated gene repair in the mouse liver.

11 Nov 2020

Nanoparticles could be used to deliver drugs to the brain to treat neurodegenerative diseases

Researchers from the Institut national de la recherche scientifique (INRS) have shown that nanoparticles could be used to deliver drugs to the brain to treat neurodegenerative diseases.

10 Nov 2020

Genetic predispositions affect the efficacy of COVID-19 drugs

A paper recently uploaded to bioRxiv* aimed to utilize genome-wide CRISPR screening to identify genes involved in modulating the activity of COVID-19 drugs.

29 Oct 2020

Scientists develop human airway stem cells to accelerate research on COVID-19, influenza

For the first time, researchers have successfully created airway basal stem cells in vitro from induced pluripotent stem cells by reprogramming blood cells taken from patients.

27 Oct 2020

New research indicates the link between diabetes and SARS-CoV-2 viral infection

Recently, researchers explained that infection by certain enteroviruses could possibly activate diabetes.

22 Oct 2020

Researchers demonstrate the impact of epithelial cells, mammary microenvironment on breast cancer cells

The cover for issue 30 of Oncotarget features Figure 4, "RNAseq results demonstrating differences between normal, cancer, and redirected cells," by Frank-Kamenetskii, et al. which reported that the influence of breast cancer cells on normal cells of the microenvironment, such as fibroblasts and macrophages, has been heavily studied but the influence of normal epithelial cells on breast cancer cells has not.

19 Oct 2020

Researchers develop a new method for siRNA stabilization

In the gene controlling mechanism, known as RNA interference, the expression of particular genes is downregulated by siRNAs or endogenic microRNAs.

19 Oct 2020

VAV1 gene mutations may promote growth of T-cell tumors in laboratory mice

Life is an exquisite orchestration of growth and change, with checks and balances that fine-tune complex entwined interactions, both intrinsic and external.

13 Oct 2020

Oncopig fulfills the unmet clinical modeling needs for hepatocellular carcinoma

Volume 11, Issue 28 of Oncotarget features "Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation" by Gaba et, al. which reported that reliable development of Oncopig HCC cell lines was demonstrated through hepatocyte isolation and Cre recombinase exposure across 15 Oncopigs.

12 Oct 2020

in vivo News and Research

Mice infused with CD5-deleted CAR T cells showed significant reduction in tumor size

Researchers develop new tool to study genes associated with autism spectrum disorder

First functional analysis of cytokine IL-15L using rainbow trout

Gaining new insights into bacterial pneumonia

Astrocytes regulate inhibitory synapses by binding to neurons

Discovering a new step in immune cell generation

Dietary induction of hepatocyte regeneration could help enhance gene repair in the liver

Nanoparticles could be used to deliver drugs to the brain to treat neurodegenerative diseases

Genetic predispositions affect the efficacy of COVID-19 drugs

Scientists develop human airway stem cells to accelerate research on COVID-19, influenza

New research indicates the link between diabetes and SARS-CoV-2 viral infection

Researchers demonstrate the impact of epithelial cells, mammary microenvironment on breast cancer cells

Researchers develop a new method for siRNA stabilization

VAV1 gene mutations may promote growth of T-cell tumors in laboratory mice

Oncopig fulfills the unmet clinical modeling needs for hepatocellular carcinoma

Researchers test the effect of hydroxychloroquine versus favipiravir in SARS-CoV-2−infected hamsters

Safe, efficient concentration of low volume samples with BioChromato's Smart Evaporator C1

Study sheds new light on cell migration in 3D environments

Dried plum diet prevents bone loss associated with spinal cord injury

Microscope Lens Inspired By Lighthouse

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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