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Researchers use genome-wide CRISPR technology to identify leukemia's weakness

A team of researchers at University of California San Diego School of Medicine and Moores Cancer Center used CRISPR technology to identify key regulators of aggressive chronic myeloid leukemia, a type of cancer that remains difficult to treat and is marked by frequent relapse.

From UC San Diego 21 Apr 2020

Study reveals the formation of tuft cells and their role in immunity

Chronic pancreatitis, or persistent inflammation of the pancreas, is a known risk factor that leads to the development of pancreatic cancer, which is the third-deadliest cancer in the United States.

20 Apr 2020

Study shows how human embryonic stem cells commit to early specialization

Scientists at the Francis Crick Institute have identified the point when stem cells in human embryos irreversibly commit to specialization.

20 Apr 2020

Genetic variability of immune system affects severity of COVID-19

Genetic variations in the immune system of humans may have an impact on the vulnerability to, and severity of the coronavirus disease (COVID-19).

20 Apr 2020

Advanced simulations show how to improve efficiency of gene therapy

Diseases with a genetic cause could, in theory, be treated by supplying a correct version of the faulty gene.

20 Apr 2020

Stem Cells In Embryos Commit To Specialization Surprisingly Early

The point when human embryonic stem cells irreversibly commit to becoming specialized has been identified by researchers at the Francis Crick Institute.

20 Apr 2020

Study Reveals Bile Metabolite Of Gut Microbes Boosts Immune Cells

A study has discovered a novel means by which bacterial colonies in the small intestine support the generation of regulatory T cells.

20 Apr 2020

Genetics Linked To Childhood Problems

Emotional, social and psychiatric problems in children and adolescents have been linked to higher levels of genetic vulnerability for adult depression.

20 Apr 2020

Cancer Drug Resistance Study Raises Immune Red Flags

Sooner or later, most cancer patients develop resistance to chemotherapy drugs designed to kill their cancer, forcing oncologists to seek alternatives.

20 Apr 2020

Novel protein facilitates a critical event in mammalian fertilization

Fertilization is a fundamental process in sexual reproduction when the combination of male and female gametes blends genetic material to create a new unique individual. Now, researchers from Japan have identified a new factor that may help orchestrate this vitally complex life event.

From Osaka University 17 Apr 2020

Sensitive technique makes it possible to study the delivery of RNA drugs

In recent years, RNA molecules, with the ability to affect or turn off pathogenic genes, have become promising drug candidates in several areas.

17 Apr 2020

Study clears potential obstacle to using gene drive strategy to control mosquitoes

New research from entomologists at UC Davis clears a potential obstacle to using CRISPR-Cas9 "gene drive" technology to control mosquito-borne diseases such as malaria, dengue fever, yellow fever and Zika.

From The University of California, Davis 17 Apr 2020

Rare structural genetic variants could play a role in schizophrenia

Most of the research focused on the genetics of schizophrenia has aimed at understanding the function played by genes in the development and heritability of schizophrenia.

17 Apr 2020

Experience Matters For Immune Cells

The discovery that immune T cells have a spectrum of responsiveness could shed light on how our immune system responds to infections and cancer.

17 Apr 2020

Whole Genome Sequencing Reveals Secrets Of Schizophrenia

Most research about the genetics of schizophrenia has sought to understand the role that genes play in the development and heritability of schizophrenia.

17 Apr 2020

UTSW researchers solve structure of key protein involved in muscle contraction

Researchers at UT Southwestern Medical Center have uncovered the detailed shape of a key protein involved in muscle contraction.

16 Apr 2020

Study shows how vulnerable cells armor themselves against infection

Cells in some of the body's most vulnerable entry routes to bacterial infection buffer themselves when the immune system detects danger by reorganizing the cholesterol on their surfaces, a new study led by UTSW scientists suggests.

16 Apr 2020

New study on transposable elements could help advance understanding of genetic evolution

There has been very little knowledge of ways in which transposable elements play a role in gene regulation. Transposable elements are small DNA pieces with the ability to replicate and scatter themselves in the genome.

16 Apr 2020

Identifying Potential Drugs Earlier In Discovery

Scientists have developed a technique that could significantly reduce the time of discovering potential new antibody-based drugs to treat disease.

16 Apr 2020

Improving drug targets for asthma and rheumatoid arthritis

Researchers have found that immune T cells exhibit a range of responsiveness. This finding could offer insights into how the immune system of humans responds to infections and cancer, and what goes wrong in immune diseases.

16 Apr 2020