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New computer program can help map individual nerve cells in worms

A new computer program has been developed by scientists who are focused on interpreting the mechanism of the brain in high-definition and at the single-cell level of detail.

19 Mar 2020

Role of MCL1 in maintaining intestinal homeostasis

An international group of scientists from the University of Zurich, the University Hospital Zurich, Heidelberg, and Glasgow have discovered a new function of MCL1, the protein that regulates cell death.

19 Mar 2020

Study discovers structure of bacterial enzyme that breaks down amino acid found in collagen

Chemists from MIT and Harvard University have elucidated the structure of a strange bacterial enzyme with the ability to break down an amino acid found in collagen.

18 Mar 2020

New CRISPR technology targets thousands of genes

Thanks to CRISPR-based genetic screens, researchers were able to detect genes that play a major role in lung cancer metastasis, cancer immunotherapy, sickle-cell anemia, and a host of other medical disorders.

18 Mar 2020

Newly discovered genes can help grow crops with minimum synthetic fertilizer

By examining the first hornwort genomes, an international team of researchers headed by the University of Zurich (UZH) and the Boyce Thompson Institute has shed light on the origin of land plants.

17 Mar 2020

More efficient, cost-effective method for accurate synthesis of DNA

DNA is a genetic material that continues to survive only through replication, either naturally or synthetically. Humans require reproduction of DNA to replace damaged or old cells, but the potential to replicate DNA in a laboratory setting can allow scientists understand the disease mechanisms or the platform to develop treatments.

17 Mar 2020

Biochemical, analytical high-throughput methods used to map proteome of plants

Plants play a crucial role in the survival of life on earth. They offer oxygen for breathing and food for all organisms, as well as regulate the planet’s climate. Proteins are vital in controlling all aspects of life, including plants.

13 Mar 2020

Researchers uncover a surprising property of blood stem cells

A Franco-German research team led by Prof. Michael Sieweke, from the Center for Regenerative Therapies TU Dresden and the Center of Immunology of Marseille Luminy, today uncovered a surprising property of blood stem cells: not only do they ensure the continuous renewal of blood cells and contribute to the immune response triggered by an infection, but they can also remember previous infectious encounters to drive a more rapid and more efficient immune response in the future.

13 Mar 2020

Study finds impact of specific gene on neurodevelopment, causing ASD and macrocephaly

During the developmental phase of brains, a number of moving parts occur—and if mutations occur during the early neurodevelopment, it can result in disorders such as autism and macrocephaly.

12 Mar 2020

Study explains “dark” portion of human genome implicated in various disorders

A “dark” part of the human genome has puzzled researchers for many years, similar to an enigmatic dark matter that accounts for 85% of the universe.

12 Mar 2020

New canine study can benefit diagnostics and treatment of retinitis pigmentosa

A study performed on canines at the University of Helsinki characterizes a gene variant in the regulatory region of the retina that causes abnormal functioning of retinal genes and, ultimately, leads to loss of vision in dogs.

11 Mar 2020

Research on mice shows unexpected effect of intermittent fasting on fat metabolism

Australian scientists have used sophisticated analytical tools to understand the effect of intermittent fasting on the liver to help mitigate disease.

11 Mar 2020

Study reports first-ever application of CRISPR-Cas12b system in plant genome engineering

In a study reported recently in Nature Plants, Yiping Qi—assistant professor of Plant Science at the University of Maryland—has found a new CRISPR genome engineering system, called CRISPR-Cas12b, that is viable in plants for the first time.

10 Mar 2020

New chromosome-level detectors developed to monitor cellular activity

For researchers investigating the regulatory processes in cells that are vital to all life, an innovative system that amplifies gene expression signals could be a turning point.

10 Mar 2020

Statistics used to find how genetics influence coffee intake

Some people feel like drinking three cups of coffee in a day while others feel content with just one cup, and some others give up entirely. Why is it so?

9 Mar 2020

Nucleosomal DNA Dynamics Mediate Oct4 Pioneer Factor Binding

An international team of researchers has disproved the role of an essential protein, known as Oct4, in regulating gene expression.

22 Feb 2020

Distinct loss-of-function variants cause shared clinical features in neuronal development disorders

Researchers have shown that mutations in four distinct genes that lead to Kleefstra syndrome.

20 Feb 2020

Understanding bipolar disorder and its potential future developments

Bipolar disorder is estimated to affect around 1 to 4% of the population, but understanding the underlying genetics has proved a major challenge.

15 Feb 2020

Considering evolution of the cancer genome in metastatic disease

Metastasis refers to the spread of cancer cells from primary tumors to distant sites that they then colonize to form a metastatic tumor.

13 Feb 2020

A new study finds a potential immunotherapeutic pan-target on cancer cells

In a genome-wide CRISPR-Cas9 screen published in Nature Immunology in January 2020, a group of researchers described a potential universal target on cancer cells.

12 Feb 2020