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New Insights into Recessive Genetic Causes of Developmental Disorders

Researchers have carried out the most extensive and varied investigation to date regarding the role that recessive genetic alterations play in developmental disorders.

24 Sep 2024

New Gene Editing Tool Shows Promise for Treating Diseases

Bacterial and archaeal CRISPR-Cas systems, comprising protein and RNA components, were initially developed as a natural defense mechanism against invading viruses.

24 Sep 2024

New Method Detects Peroxymonocarbonate and Its Role in Cellular Responses

High levels of carbon dioxide (CO2) in the atmosphere can alter not only the climate of our planet but also the functioning of our cells.

24 Sep 2024

Study Uncovers Cholesterol's Role in Membrane Structure and Function

A new study by Rice University researchers led by Jason Hafner could open new pathways for understanding how cholesterol influences cell membranes and their receptors, paving the way for future research on diseases linked to membrane organization.

24 Sep 2024

A Novel Function for STING in DNA Damage Response

A study published in the journal Molecular Cell has shed light on the multifaceted role of STING, a protein previously implicated in antiviral signaling pathways. The study reveals that STING also plays a crucial part in facilitating cellular stress resolution and promoting cell survival.

23 Sep 2024

A Computational Toolkit for Large-Scale Metabolomics Analysis

A computational workflow for analyzing massive data sets in metabolomics, the study of tiny chemicals found within cells, biofluids, tissues, and entire ecosystems has been developed by a research team led by experts at the University of California, Riverside.

23 Sep 2024

A New Understanding of How the Brain Adapts to Changing Situations

In a constantly changing world, animals, including humans, need to quickly adapt to their environment and learn to make decisions that lead to the best possible outcomes. In most cases, this type of learning happens through direct experience; when faced with a choice between two particular items or events, animals resort to previous experience involving the same options.

23 Sep 2024

Unveiling the Molecular Mechanisms of Shigella flexneri Infection

Virginia Tech researchers have learned how bacteria manipulate molecules to infect the host organism.

23 Sep 2024

A Novel Biosensor for Calcium Detection in Fruit Flies, Zebrafish, and Mice

In 2021, the Janelia group leaders reported that they had developed a way to combine Schreiter's engineered protein biosensors and Lavis's bright, fluorescent Janelia Fluor dyes.

23 Sep 2024

AI-Driven Insights into Lasso Peptide Biosynthesis

Lasso peptides are natural products made by bacteria. Their unusual lasso shape endows them with remarkable stability, protecting them from extreme conditions. In a new study, published in Nature Chemical Biology, researchers have constructed and tested models for how these peptides are made and demonstrated how this information might be used to advance lasso peptide-based drugs into the clinic.

23 Sep 2024

A New Understanding of the Effects of Fever on Immune Cells

Fever temperatures rev up immune cell metabolism, proliferation and activity, but they also -; in a particular subset of T cells -; cause mitochondrial stress, DNA damage and cell death, Vanderbilt University Medical Center researchers have discovered.

23 Sep 2024

Unraveling the Genetic Mechanisms Underlying Fruit Size and Sugar Content in Wax Apple

A recent study has successfully decoded the autotetraploid genome of the wax apple, uncovering its genetic evolution and key factors driving fruit diversity. The research highlights the fruit's rich antioxidant profile, with promising implications for human health and breeding strategies aimed at enhancing nutritional value.

23 Sep 2024

DNA Duplication Determines Horse Coat Color and Melanoma Risk

Scientists from the Texas A&M College of Veterinary Medicine and Biomedical Sciences (VMBS) and Uppsala University in Sweden now understand why some gray horses turn completely white as they age, while others remain an eye-catching "dappled" gray color.

23 Sep 2024

Harnessing the Power of Beneficial Bacteria to Fight Enterobacteriaceae

Antibiotic-resistant bacterial infections often occur in patients with chronic inflammatory intestinal conditions, such as inflammatory bowel disease, and in patients who have taken antibiotics for a long time. Gram-negative bacteria such as Enterobacteriaceae are a common cause of these infections and have few treatment options. Fecal microbiota transplants have shown promise to curb some of these infections, but their composition varies between batches and they aren't always successful.

23 Sep 2024

Scientists Develop Lab-Grown Muscle Stem Cells for Advanced Regenerative Therapies

Recent findings reveal that induced satellite cells can effectively regenerate muscle tissue, outperforming traditional myoblasts in engraftment and function.

23 Sep 2024

Novel Tool Helps Identify Snake Venom Genes Across Species

Only about ten percent of the world's roughly 4,000 snake species have venom strong enough to seriously hurt a human, but that's enough for snake bites to be an important public health concern.

20 Sep 2024

New Method Analyzes Tooth Enamel Proteins to Gain Insights into Human Health History

A new way of looking at tooth enamel could give scientists a path to deeper understanding of the health of human populations, from the ancient to the modern.

20 Sep 2024

Comprehensive multi-omics approach reveals detailed insights into diabetes mechanisms

In a recent study published in Nature Communications, researchers utilized a comprehensive multi-omics approach, integrating genomic, proteomic, and metabolomic data from a diverse cohort, to uncover detailed molecular interactions and identify distinct diabetes subgroups.

20 Sep 2024

Sodium Transport Found to Play a Surprising Role in Mitochondrial Energy Production

The GENOXPHOS (Functional Genetics of the Oxidative Phosphorylation System) group at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has discovered a crucial role of sodium in the generation of cellular energy.

20 Sep 2024

Gene-Based Tool Predicts Cherry Blossom Blooming Times

Japan is well-known for its sakura, or cherry blossoms, which bloom in the southern Kyushu region and ascend to the far north of Hokkaido in the spring.

20 Sep 2024