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Novel platform identifies genes that control biologic processes

Inflammatory neurological diseases, such as multiple sclerosis (MS), can arise when cell-to-cell communication between cells in the central nervous system (CNS) goes awry. But exactly how this cellular crosstalk leads to the molecular changes that drive disease remain unknown.

13 Mar 2023

COVID-19 has taken a limited toll on the mental health, finds study

COVID-19 has taken a relatively limited toll on the mental health of most people around the globe, according to a paper published today in the BMJ by a McGill University-led research team involving collaborators from McMaster University, the University of Toronto, and other institutions.

10 Mar 2023

Study identifies a novel rare mutation in gene linked to Harlequin Ichthyosis

Harlequin ichthyosis (HI) is a severe genetic skin disorder characterized by thick white, brown, or dark brown patches on the skin covering a newborn's entire body. HI has a low incidence of 1 per 300,000 live births but comes with the highest mortality rate among skin conditions. It is caused by a mutation in the ABCA12 gene, which codes for a protein involved in transporting lipids necessary for the formation of the skin barrier. Such protein shortage leads to a weaker epidermal barrier.

9 Mar 2023

Monitoring the development and maturation of cardiomyocytes using tissue-embedded devices

Research in animal models has demonstrated that stem-cell derived heart tissues have promising potential for therapeutic applications to treat cardiac disease. But before such therapies are viable and safe for use in humans, scientists must first precisely understand on the cellular and molecular levels which factors are necessary for implanted stem-cell derived heart cells to properly grow and integrate in three dimensions within surrounding tissue.

9 Mar 2023

Liver-produced hormone protects mice against the harmful effects of intoxication

A shot of a liver-produced hormone called FGF21 sobered up mice that had passed out from alcohol, allowing them to regain consciousness and coordination much faster than those that didn't receive this treatment, UT Southwestern researchers report in a new study.

8 Mar 2023

Study pinpoints a splicing deregulation that causes therapeutic vulnerability in pediatric AML

Pediatric acute myeloid leukemia or pAML is a childhood blood cancer, one that has proved confounding to clinicians and researchers, with a high relapse rate and relatively few identified genetic mutations (compared to the adult version) that might explain its cause.

8 Mar 2023

Revolutionary drug blocks a gene associated with driving the spread of bone cancer

Researchers at the University of East Anglia have developed a new drug that works against all of the main types of primary bone cancer.

8 Mar 2023

Socioeconomic and genetic factors likely interact in an additive way to increase risk of metabolic diseases

New research led by investigators at Massachusetts General Hospital, a founding member of Mass General Brigham, indicates that socioeconomic and genetic factors likely interact in an additive way to affect people's risks of developing obesity and type 2 diabetes.

8 Mar 2023

AI tool can accurately identify normal and abnormal chest X-rays in a clinical setting

An artificial intelligence tool can accurately identify normal and abnormal chest X-rays in a clinical setting, according to a study published in Radiology, a journal of the Radiological Society of North America.

8 Mar 2023

Study pinpoints a key cause of metastasis from an aggressive form of pediatric brain cancer

New research pinpoints a key cause of metastasis from an aggressive form of brain cancer in children and provides a potential new therapy for treating these tumors in the future.

7 Mar 2023

New insights into the distribution and regulation of meiotic DSB hotspots

A new method, DNA End tailing and sequencing (DEtail-seq), for meiotic DNA double-strand break (DSB) profiling was developed recently.

3 Mar 2023

Researchers provide an entirely new perspective on tissue oxygenation

Cardiovascular medicine, hematology and pulmonary medicine may soon have the first-ever therapies to correct poor tissue oxygenation, a key driver of disease in millions, including peripheral artery disease, sickle cell disease, heart failure, stroke, emphysema and many others.

2 Mar 2023

Novel framework provides solutions to evade detoxification networks

Scientists at St. Jude Children's Research Hospital have demonstrated how drug makers can avoid two key problems: toxicity and resistance. The researchers made slight changes to a small molecule to reduce its metabolism and elimination by the cellular detoxification network regulated by the pregnane X receptor (PXR). This research provides a framework to develop solutions to the long-standing issue of how to evade detoxification networks using medicinal chemistry. The findings were published today in Proceedings of the National Academy of Sciences.

1 Mar 2023

Women over 50 with genetic BRCA1 or BRCA2 mutation face a high risk of cancer

Although genetic mutations in BRCA1 or BRCA2 are associated with a younger onset of breast and ovarian cancer, women with these genetic mutations continue to face a high risk of cancer incidence after age 50, even if they have not been previously diagnosed with cancer.

27 Feb 2023

Herpesvirus infection boosts host cellular immunity: Study

A new editorial was published in Genes & Cancer on January 19th, 2023, entitled, "Severe herpesvirus infection beats adult T-cell leukemia/lymphoma."

27 Feb 2023

Researchers tease apart the molecular components involved in abdominal aneurysms

When the artery that supplies the stomach and the liver forms a bulge that ruptures, this medical emergency results in the deaths of 50 percent of patients before they reach the hospital.

24 Feb 2023

Discovery of a lung stem cell subset provides opportunity for new COPD treatments

Respiratory viral infections pose significant morbidity and mortality to patients with chronic lung diseases like emphysema and COPD, causing exacerbations that drive destruction of normal lung tissue, and leading to one of the most common diagnoses for hospital admissions.

24 Feb 2023

Study uncovers differences in how AstraZeneca and Pfizer COVID-19 vaccines affect the immune system

A new Australian study led by SAHMRI and Flinders University has uncovered fundamental differences in how the AstraZeneca and Pfizer COVID-19 vaccines impact the immune system.

23 Feb 2023

MIT engineers develop new procedure to 3D print a soft, flexible replica of patient's heart

No two hearts beat alike. The size and shape of the the heart can vary from one person to the next. These differences can be particularly pronounced for people living with heart disease, as their hearts and major vessels work harder to overcome any compromised function.

23 Feb 2023

Limiting antibiotic use in livestock associated with reduction in antibiotic-resistant infection

A California policy restricting antibiotic use in animals raised for food is associated with a reduction in one type of antibiotic-resistant infection in people in the state, according to a new study published today in the journal Environmental Health Perspectives.

23 Feb 2023

Hospital News and Research

Novel platform identifies genes that control biologic processes

COVID-19 has taken a limited toll on the mental health, finds study

Study identifies a novel rare mutation in gene linked to Harlequin Ichthyosis

Monitoring the development and maturation of cardiomyocytes using tissue-embedded devices

Liver-produced hormone protects mice against the harmful effects of intoxication

Study pinpoints a splicing deregulation that causes therapeutic vulnerability in pediatric AML

Revolutionary drug blocks a gene associated with driving the spread of bone cancer

Socioeconomic and genetic factors likely interact in an additive way to increase risk of metabolic diseases

AI tool can accurately identify normal and abnormal chest X-rays in a clinical setting

Study pinpoints a key cause of metastasis from an aggressive form of pediatric brain cancer

New insights into the distribution and regulation of meiotic DSB hotspots

Researchers provide an entirely new perspective on tissue oxygenation

Novel framework provides solutions to evade detoxification networks

Women over 50 with genetic BRCA1 or BRCA2 mutation face a high risk of cancer

Herpesvirus infection boosts host cellular immunity: Study

Researchers tease apart the molecular components involved in abdominal aneurysms

Discovery of a lung stem cell subset provides opportunity for new COPD treatments

Study uncovers differences in how AstraZeneca and Pfizer COVID-19 vaccines affect the immune system

MIT engineers develop new procedure to 3D print a soft, flexible replica of patient's heart

Limiting antibiotic use in livestock associated with reduction in antibiotic-resistant infection

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