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Researchers Develop Mycobacteria Strains with Kill Switches for Safer TB Vaccines

Working toward more effective tuberculosis (TB) vaccines, researchers at Weill Cornell Medicine have developed two strains of mycobacteria with "kill switches" that can be triggered to stop the bacteria after they activate an immune response.

26 Feb 2025

T Cells May Hold the Secret to Fighting Dengue Virus

Children who experience multiple cases of dengue virus develop an army of dengue-fighting T cells, according to a new study led by scientists at La Jolla Institute for Immunology (LJI).

25 Feb 2025

Zinc-Carrying Proteins Activate Proton Pump Inhibitors in Neutral Environments

Acid reducing medicines from the group of proton pump inhibitors (PPIs) are best-selling drugs that prevent and alleviate stomach problems.

22 Feb 2025

Intermittent Fasting Disrupts Development of Insulin-Producing Beta Cells in Young Mice

A recent study reveals that age plays a significant role in the outcomes of intermittent fasting. Researchers from Technical University of Munich (TUM), LMU Hospital Munich, and Helmholtz Munich discovered that chronic intermittent fasting disrupted the development of insulin-producing beta cells in young mice.

17 Feb 2025

Scientists Uncover Mechanism Linking OPN3 to Food Intake Regulation

Scientists discovered years ago that the hypothalamus - which helps to manage body temperature, hunger, sex drive, sleep and more - includes neurons that express the protein opsin 3 (OPN3).

17 Feb 2025

Study Reveals Limits of Epigenetic Clocks in Predicting Biological Age

Epigenetic clocks show varying accuracy across tissues, underscoring the need for tissue-specific calibration in biological age assessments and health research.

13 Feb 2025

Researchers Unveil Mechanisms Behind Neural Stem Cell Activation and Quiescence

A University of Ottawa neuroscientist has led a Canadian research team to reveal important new insights into the activation dynamics of neural stem cells (NSCs).

8 Feb 2025

New Technology for Visualizing Gene Activity in Single Cells

How do bacteria whether harmless ones residing in human bodies or those causing diseases coordinate their activities?

6 Feb 2025

First Cell Atlas of Focal Cortical Dysplasia Offers New Insights for Treatment

Using a single-cell sequencing technique, Brazilian researchers have created the first cell atlas of focal cortical dysplasia (FCD), a malformation of the cerebral cortex that leads to drug-resistant epilepsy.

31 Jan 2025

New Consensus Paper Advances Nomenclature for Mitochondria Transfer and Transplantation

Most animal, plant and fungal cells contain organelles called mitochondria. These descendants of a primordial bacterial endosymbiont still preserve distinct genes and are known for their ability to create ATP as chemical energy.

28 Jan 2025

Long-Read Sequencing Brings New Hope for Rare Disease Diagnosis and Treatment

One in every 10 people worldwide is impacted by a rare genetic disease but about 50% of them remain undiagnosed despite rapid increases in genetic technology and testing.

27 Jan 2025

New Research Sheds Light on Y Chromosome’s Role in Male Infertility

Researchers at the Crick have uncovered which genes on the Y chromosome regulate the development of sperm and impact fertility in male mice.

24 Jan 2025

Immune System Insights Could Lead to Tailored Treatments for Childhood Cancer

Researchers at Karolinska Institutet and the Astrid Lindgren Children's Hospital in Sweden have determined how children's immune systems react to different kinds of cancer depending on their age.

21 Jan 2025

Epigenetic Mechanism Controls Placental Blood Vessel Formation

If the development of blood vessels in the placenta is impaired, fetal growth retardation may result. Scientists from the German Cancer Research Center (DKFZ) and the Mannheim Medical Faculty of Heidelberg University discovered that the correct development of functioning blood vessels in the mouse placenta is controlled epigenetically: One of the enzymes that modify gene activity using methyl groups is responsible.

16 Jan 2025

Outer Ears Evolved From Fish Gills Through Unique Genetic Mechanism

The outer ear is unique to mammals, but its evolutionary origin has remained a mystery. According to a new study published in Nature from the USC Stem Cell lab of Gage Crump, this intricate coil of cartilage has a surprisingly ancient origin in the gills of fishes and marine invertebrates.

10 Jan 2025

Scientists Uncover Circuit Controlling Neuron Migration in Brain Development

The journey of a thousand miles begins with a single step, but for developing neurons, this first step relies on collaboration from multiple signaling pathways.

10 Jan 2025

Multi-Site Effort to Understand Viral Influences on Human Health

For more than ten years, researchers have been investigating the microbiome, the ecosystem of microorganisms that inhabit the body, and its impact on health and disease.

10 Jan 2025

New Discovery Sheds Light on How Monoamines Regulate Brain Rhythms

A collaborative effort between Mount Sinai and Memorial Sloan Kettering Cancer Center has shed valuable light on how monoamine neurotransmitters such as serotonin, dopamine, and now histamine help regulate brain physiology and behavior through chemical bonding of these monoamines to histone proteins, the core DNA-packaging proteins of our cells.

9 Jan 2025