DNA Damage News and Research

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The Hidden Link Between Cell Membrane Damage and Cellular Senescence Revealed

Researchers from the Okinawa Institute of Science and Technology (OIST) along with the researchers from University of Tokyo, Nagoya University, and Nagoya City University, found that disruption to the cell membrane accelerates cellular senescence or cell aging.

23 Feb 2024

Telomerase's Double-Edged Sword: Preventing DNA Repair Mishaps

The natural ends of chromosomes appear alarmingly like broken DNA, much as a snapped spaghetti strand is difficult to distinguish from its intact counterparts.

16 Feb 2024

Researchers Identify Genes Linked to Genomic Instability and DNA Damage

More than one hundred key genes linked to DNA damage have been uncovered through systematic screening of nearly 1,000 genetically modified mouse lines, in a new study published today (14 February) in Nature.

16 Feb 2024

New Understanding of DNA Damage and Disease Risk

Researchers identified 145 genes that are essential for the health of the genome and potential treatments for human genomic disorders.

15 Feb 2024

Unlocking RNA Secrets: New Method Exposes Gene Expression's Hidden Hurdles

A new study demonstrates that a method may identify, for the first time, the frequency and precise location of a molecular occurrence known as "backtracking" across the genetic material (genome) of any species.

12 Feb 2024

National Korea Maritime and Ocean University Researchers Explore the Impact of Microplastics and Toxin Exposure on Goldfish

Microplastic particles can travel long distances in oceans and are known to carry with them harmful and persistent organic pollutants like benzo[α]pyrene (BaP), a polycyclic aromatic hydrocarbon.

11 Jan 2024

Researchers Identify Key Protein in Maintaining Two Organelles, Thereby Preventing Cellular Aging

Healthy organelles are essential to the operation of the cell, just as healthy organs are essential to human well-being.

2 Jan 2024

Sirtuin 6 Boosts DNA Repair in Aging Cartilage Cells

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes."

20 Dec 2023

Tokyo Metropolitan University Decodes DNA Repair Mechanisms

Tokyo Metropolitan University researchers have uncovered crucial aspects of the DNA repair mechanism within human bodies.

16 Nov 2023

Nucleotide Metabolite Controls DNA Repair and Cancer Sensitivity

Scientists have unraveled the mechanism by which a particular metabolite regulates DNA repair activity and the susceptibility of tissues to cancer treatment.

3 Nov 2023

Targeting eIF4A with Zotatifin: A Promising Strategy for TNBC Treatment

Enhancing treatment options for triple-negative breast cancer (TNBC), a highly aggressive tumor with a grim prognosis and limited therapeutic possibilities has proven to be a formidable challenge.

31 Oct 2023

New Insights Into the Role of Autophagy in Yeast Aging

Aging is an inevitable process that impacts all cell types, making yeast cells a common choice as a model organism in aging research.

26 Oct 2023

Researchers Develop Drug Targeting lncRNA TUG1 to Control Brain Tumor Growth in Mice

A new study has unraveled a crucial link between how cancer cells cope with replication stress and the role of Taurine Upregulated Gene 1 (TUG1). By targeting TUG1 with a drug, the researchers were able to control brain tumor growth in mice, suggesting a potential strategy to combat aggressive brain tumors such as glioblastomas.

13 Oct 2023

Scientists Explain How Enhancer Reprogramming Promotes Tumor Cell Growth

Cancer cells can boost tumor development by hijacking enhancer DNA, which is typically utilized when tissues and organs form, according to researchers at the University of Toronto (U of T).

29 Sep 2023

Unraveling the Link Between Chromosomal Instability and Cancer Spread

Chromosomal instability is a phenomenon marked by rapid alterations in the count and configuration of chromosomes during cell division. This occurrence is prevalent in solid tumors and is closely associated with the aggressive dissemination of cancer, known as metastasis.

27 Sep 2023

Newly Discovered Fungus Helps Destroy a Harmful Food Toxin

Patulin is a harmful mycotoxin produced by fungi typically found in damaged fruits, including apples, pears, and grapes.

1 Sep 2023

Elephants may Hold Secrets to Long Life

Indiana University researcher Daniella Chusyd is studying human aging in an unlikely way: through elephants.

7 Aug 2023

Discovering Age and Sex-Specific Obesity Genes in the Genome

Right from impacting how the human body stores fat to how the brain regulates appetite, hundreds of genes, together with environmental factors, jointly identify weight and body size.

3 Aug 2023

Analyzing DNA Damage-Induced NF-κB Targeted by Novel Small Molecule Inhibitors

Chemotherapy and radiotherapy aim to destroy cancer cells by inducing DNA double-strand breaks – damage that, once inflicted, usually causes the cells to die. But damage to a cell's genetic material also activates a signaling pathway called IKK/NF-κB that helps prevent cell death, thus limiting the success of these treatments in patients.

28 Jul 2023

Cells with “Jumping Genes” Self-Destruct in the Early Stages of Development

A previously unknown type of cell that self-destructs within days of forming as part of a quality control procedure to protect the growing fetus has been found by researchers studying gene activity data of the early human embryo.

21 Jun 2023