DNA Methylation News and Research

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DNA methylation is a type of chemical modification of DNA that can be inherited and subsequently removed without changing the original DNA sequence. As such, it is part of the epigenetic code and is also the most well characterized epigenetic mechanism.

Study Offers Valuable Insights Into Mutagenesis Mechanisms and Cancer Evolution

Mutations are the changes in the DNA that gradually occur in human cells as they replicate, and the organism grows and ages.

13 Apr 2024

Study Reveals Gut Microbiome's Influence on Premature Aging in Chronic HIV Patients

The Wistar Institute's associate professor Mohamed Abdel-Mohsen, Ph.D., has demonstrated, with his lab and collaborators, a connection between viral damage to the gut and premature biological aging.

22 Feb 2024

New DNA Methylation-Based Analysis Provides Accurate Assessment of Pancreas Cell Composition

Research introduces new DNA methylation-based method for accurately assessing cell composition in the human pancreas, addressing a critical gap in diabetes research.

7 Feb 2024

Study Suggests a Link Between DNA Methylation Disorder and Epigenetic Clocks

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, "Epigenetic drift underlies epigenetic clock signals, but displays distinct responses to lifespan interventions, development, and cellular dedifferentiation."

7 Feb 2024

NLRC5 Gene Reactivation Boosts Tumor-Killing Immunity

Every human cell has class I major histocompatibility complex (MHC) molecules on its surface, which are immune complexes. The immune system needs MHC class I molecules to identify and eradicate cancer.

30 Jan 2024

Epigenetic Key Unlocks Treatment Path for Endocrine-Resistant Breast Cancer

Endocrine resistance – a major cause of breast cancer deaths – can be underpinned by an epigenetic change called DNA methylation, researchers at the Garvan Institute of Medical Research have discovered.

10 Jan 2024

Examining the Link Between Sleep Alteration and Aging in Jewel Wasps

Parents of newborns might sense a rapid aging effect during the early months of sleepless nights. Currently, researchers at the University of Leicester are exploring the intriguing possibility that the key to a long and healthy life lies in a restful night's sleep and human DNA.

10 Nov 2023

Obesity Susceptibility may be Written Into Molecular Processes of Human Cells

A susceptibility to gain weight may be written into molecular processes of human cells, a Washington State University study indicates.

2 Nov 2023

DNA Methylation Enables Plants Adapt in a Warm World

Plants increasingly need to adapt quickly to preserve their existence as global warming continues to reshape ecosystems.

13 Oct 2023

Study Uncovers Epigenetic Mechanism in the Regulation of Phytopathogenic Fungal Virulence

This study is led by Dr Cheng-Guo Duan (Center of Excellence in Molecular Plant Sciences, Chinese Academy of Sciences).

25 Sep 2023

Epstein-Barr Virus Epigenome Targeted for Potential Cancer Treatment

Now, scientists at The Wistar Institute have discovered a potential target for gastric cancers associated with Epstein-Barr Virus; study results were published in the journal mBio.

23 Aug 2023

Researchers Lead Innovative Studies on Mammalian Aging and Life Span

Scientists at UCLA David Geffen School of Medicine and UCLA Health led an international research team that published two articles detailing changes in DNA – changes that researchers found are shared by humans and other mammals throughout history and are associated with life span and numerous other traits.

11 Aug 2023

Elephants may Hold Secrets to Long Life

Indiana University researcher Daniella Chusyd is studying human aging in an unlikely way: through elephants.

7 Aug 2023

New Method Facilitates Early Detection and Localization of Tumors

To help with early tumor diagnosis and tumor localization, researchers have devised a technology that concurrently detects many cancer-specific DNA circulating hallmarks.

26 Jul 2023

Discovering a Major Factor Causing Aggressive Cancer

Researchers from the University of Otago have identified a crucial factor that contributes to the aggressive spread of colon cancer, marking a significant advancement in the fight against fatal tumors.

27 Jun 2023

Study Links Timing of Childhood Adversity With Epigenetic Patterns in Adolescents

Childhood adversity-;circumstances that threaten to a child's physical or psychological well-being--has long been associated with poorer physical and mental health throughout life, such as greater risks of developing cardiac disease, cancer, or depression.

14 Jun 2023

Study Finds Link Between Chemical "Marks" on DNA in Father’s Sperm and Autistic Traits in Children

Among families with children diagnosed with autism spectrum disorder, Johns Hopkins University researchers say they have found a link between chemical "marks" on DNA in the sperm of fathers and autistic traits in their 3-year-old children.

28 Apr 2023

Molecular Mechanisms That Maintain the Tissue Specificity of PKMzeta

The protein PKMzeta has been strongly associated with long-term memory formation.

19 Apr 2023

Plant Response to Elevated Carbon Dioxide is Transgenerational and Orchestrated by DNA Methylation

New research lead by Keith Slotkin, PhD, member, Donald Danforth Plant Science Center opens the door for scientists to equip plants with the tools they need to adapt to rising levels of carbon dioxide (CO2), high heat, and other stressors associated with climate change.

12 Apr 2023

Variations in methylation linked to age in the human sperm epigenome

A higher risk of reproductive and child health issues is linked to advanced paternal age. Increasing evidence points to age-related alterations in the sperm epigenome as one underlying cause.

23 Mar 2023