DNA Replication News and Research

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DNA replication, the basis for biological inheritance, is a fundamental process occurring in all living organisms to copy their DNA. This process is "semiconservative" in that each strand of the original double-stranded DNA molecule serves as template for the reproduction of the complementary strand. Hence, following DNA replication, two identical DNA molecules have been produced from a single double-stranded DNA molecule. Cellular proofreading and error-checking mechanisms ensure near perfect fidelity for DNA replication.

Protein RAD51 Acts as Guardian Against DNA Over-Replication

Every time a cell divides, its DNA is duplicated so that the two daughter cells have the same genetic material as their parent.

5 Mar 2024

3D Visualizations of the Copying Machinery Found in Chloroplasts

Plants have to carry out photosynthesis and ultimately synthesize oxygen and chemical energy with the assistance of sunlight to support life on Earth.

4 Mar 2024

Scientists Discover Dual Challenges in DNA Replication Process

Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how our DNA gets copied.

29 Feb 2024

Researchers Identify Genes Linked to Genomic Instability and DNA Damage

More than one hundred key genes linked to DNA damage have been uncovered through systematic screening of nearly 1,000 genetically modified mouse lines, in a new study published today (14 February) in Nature.

16 Feb 2024

Big Data Analysis Reveals Hidden Patterns in Human Chromosomes

IRB Barcelona researchers find 13 unique genomic patterns in unexpected patterns in mutation risks across individuals.

11 Jan 2024

How 3D DNA Architecture Shapes Cell Fate in Early Embryos

The intricate process of duplicating genetic information, referred to as DNA replication, lies at the heart of the transmission of life from one cell to another and from one organism to the next. This happens by not just simply copying the genetic information; a well-orchestrated sequence of molecular events has to happen at the right time.

21 Dec 2023

Revolutionizing Precision in Super-Resolution Microscopy

Cutting-edge super-resolution microscopy techniques can now achieve optical resolutions within the range of a few nm, corresponding to the size of cellular molecules.

4 Dec 2023

Researchers Develop Drug Targeting lncRNA TUG1 to Control Brain Tumor Growth in Mice

A new study has unraveled a crucial link between how cancer cells cope with replication stress and the role of Taurine Upregulated Gene 1 (TUG1). By targeting TUG1 with a drug, the researchers were able to control brain tumor growth in mice, suggesting a potential strategy to combat aggressive brain tumors such as glioblastomas.

13 Oct 2023

Unraveling the Link Between Chromosomal Instability and Cancer Spread

Chromosomal instability is a phenomenon marked by rapid alterations in the count and configuration of chromosomes during cell division. This occurrence is prevalent in solid tumors and is closely associated with the aggressive dissemination of cancer, known as metastasis.

27 Sep 2023

New Insights into MCM8/9 Enzyme Could Lead to Treatments for Infertility and Cancer

Scientific research requires patience. The rewards are not always immediate, and the technology needed does not always exist. Michael A. Trakselis, Ph.D., professor and director of graduate affairs for the Department of Chemistry and Biochemistry at Baylor University, understands this.

30 Aug 2023

Study Reports High-Resolution Structures of CAF-1

Since the passage of the DNA replication fork destroys nucleosomes on the DNA, chromatin inheritance during cell division requires the replication of DNA and the assembling of nucleosomes onto the duplicated DNA.

28 Aug 2023

Study Shows How Genomic Topography Influences Where Cancer Mutations Arise

Researchers at the University of California San Diego have uncovered a connection between the topography of the human genome and the presence of mutations in human cancer. They found that certain regions of the genome, which exhibit unique features, act as hotspots for the accumulation of mutations.

25 Aug 2023

Dietary Fiber Regulates Gut Microbiota and Improves Epithelial Cell Proliferation

A high-fiber diet is known to have several health benefits. Scientific studies point to protection against such diseases as cancer and diabetes.

25 Jul 2023

New View of Euchromatin in the Cell Analyzed

In their study performed, the research group discusses their novel view of euchromatin present in the cell and displays how the disclosed organization is appropriate to genome functions.

28 Jun 2023

Study Provides Evidence for Involvement of p53/p16/RB-E2F-DREAM Repressional Targets in Cellular Senescence

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 10, entitled, "Key elements of cellular senescence involve transcriptional repression of mitotic and DNA repair genes through the p53-p16/RB-E2F-DREAM complex."

14 Jun 2023

Understanding Potential Mechanisms Underlying Genetic Variation in Older Trees

Older, long-lived trees are thought to contribute more to the creation and maintenance of genetic mutations than short-lived trees, according to research on the link between the growth rate of tropical trees and the frequency of genetic mutations they collect.

7 Jun 2023

New Mechanism Controlling Cellular Proliferation in Response to Serum Revealed

Researchers of the Genome Dynamics Project team at Tokyo Metropolitan Institute of Medical Science revealed new mechanism controlling cellular proliferation in response to serum, which triggers growth of resting cells.

13 Apr 2023

How specialized plant “train tracks” can be used to feed the expanding population

A new study will examine the possibility that specialized plant “train tracks” that transport chemicals within cells could help in feeding the world’s expanding population.

From The University of Warwick 23 Mar 2023

Neural-network-based image recognition models for examining SCC defects

Scientists from Tokyo Metropolitan University have used machine learning to automate the identification of defects in sister chromatid cohesion. They trained a convolutional neural network (CNN) with microscopy images of individual stained chromosomes, identified by researchers as having or not having cohesion defects. After training, it was able to successfully classify 73.1% of new images. Automation promises better statistics, and more insight into the wide range of disorders which cause cohesion defects.

14 Mar 2023

New hexameric structure of the protein triggering antibiotic resistance discovered

All living organisms require DNA replication to ensure the genetic integrity of the following generation. On the other hand, bacteria have the ability to horizontally transfer genetic information to other bacteria.

6 Feb 2023