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Scientists Unveil Molecular Process of Polymerase Theta in Cancer Cells

DNA repair proteins act like the body's editors, constantly finding and reversing damage to our genetic code.

4 Mar 2025

Lactylation Levels Influence Cardiac Development and Regeneration in Mice

This study is led by Dr. Xiaodong Luan (Institute of Clinical Medicine, Peking Union Medical College Hospital), Dr. Shuyang Zhang (Department of Rare Diseases, Peking Union Medical College Hospital) and Dr. He Huang (Shanghai Institute of Materia Medica, Chinese Academy of Sciences).

3 Mar 2025

Mapping Bacterial Responses to Reactive Nitrogen and Oxygen Species

A study in Microbiological Research explored the impact of varying ratios of Reactive Nitrogen Species (RNS) and Reactive Oxygen Species (ROS) on pathogenic bacteria, including Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, and Pseudomonas aeruginosa.

28 Feb 2025

Unveiling the Role of Flexibility in Designer Proteins

Artificially designed proteins typically rely on building blocks with strict symmetrical rules, allowing for computational prediction of their structures.

27 Feb 2025

Danforth Center Scientists Innovate Cryopreservation for Plant Tissue Imaging

Danforth Center scientists Tessa Burch-Smith, PhD, and Kirk Czymmek, PhD, in collaboration with researchers at the CryoEM Facility at Stanford University, are embarking on a pioneering initiative to develop new cryopreservation and nanoscale imaging procedures for volume electron microscopy (vEM) of plant tissues.

26 Feb 2025

Innovative AI Software Automates Complex Microscopy Image Segmentation Tasks

Identifying and delineating cell structures in microscopy images is crucial for understanding the complex processes of life.

26 Feb 2025

Bacterial Cellulose Boosts Plant Healing, Opening New Frontiers in Agricultural Regeneration

Research shows bacterial cellulose stimulates plant tissue regeneration, activating key genes and signaling pathways for improved wound healing in agriculture.

24 Feb 2025

New Discoveries Challenge Textbook Knowledge of Mitochondrial Respiration

In an article published in the journal Trends in Biochemical Sciences, Alicia Kowaltowski, full professor at the University of São Paulo's Institute of Chemistry (IQ-USP) in Brazil, advocates the "rewriting" of textbooks on the location of the electron transport chain in mitochondria and the role of sodium in mitochondrial respiration.

20 Feb 2025

Novel Anti-CRISPR Protein Targets Cas13b RNA Nuclease

There are numerous potential uses for the CRISPR-Cas gene scissors, ranging from antiviral treatments and diagnostics to the treatment of genetic disorders.

18 Feb 2025

Gene Editing Breakthrough Creates CoQ10-Producing Rice Varieties

A team of Chinese scientists has used targeted gene editing to develop rice that produces coenzyme CoQ10 (CoQ10), a vital compound for human health.

17 Feb 2025

Computational Modeling Streamlines Antiviral Discovery

Viruses, such as those responsible for COVID-19 and HIV, present significant challenges once they enter the human body. Antiviral therapies aim to obstruct a virus or prevent its replication.

17 Feb 2025

Study Reveals Mechanisms Behind Bacterial Flagellar Motor Movement

When speaking of motors, most people think of those powering vehicles and human machinery. However, biological motors have existed for millions of years in microorganisms.

14 Feb 2025

Understanding the Complex Architecture of the Minor Spliceosome

In human cells, only a small proportion of the information written in genes is used to produce proteins. How does the cell select this information? A large molecular machine called the spliceosome continuously separates the coding and non-coding regions of our genes – and it's doing this even as you read these lines.

13 Feb 2025

High-Resolution Images Reveal How Cells Discard Faulty Spliceosomes

A sophisticated molecular machine, the spliceosome, ensures the accurate assembly of genetic information from the genome into mature mRNA after it has been transcribed into mRNA precursors.

10 Feb 2025

Cryo-EM Uncovers Hidden Complexity in Collagen Structure

The most prevalent protein in the body, collagen, has long been thought to be a predictable structural element of tissues.

10 Feb 2025

Research Reveals Key Mitochondrial Role in Social Recognition Memory

Virginia Tech neuroscientists have uncovered a mitochondrial process that supports the brain cells critical for learning, memory, and social recognition.

10 Feb 2025

Nutrient Starvation Impedes Antibiotic Efficacy in Salmonella Infections

A new study from the University of Basel, published in Nature, challenges the conventional understanding of antibiotic treatment failure. Rather than attributing such failures to a small population of highly resistant bacteria, the research suggests a different explanation.

6 Feb 2025

Scientists Decode ApoB100 Structure for Targeted Heart Disease Treatments

Low-density lipoproteins (LDL) - commonly known as bad cholesterol - have long been on scientists' radar as a major contributor to heart disease.

4 Feb 2025

New Protein Structures Could Lead to Better Treatments for Transthyretin Amyloidosis

The tiny protein known as transthyretin can cause big problems in the body when it misfolds after secretion.

29 Jan 2025

Unveiling the Architecture of Native NMDA Receptors in the Mammalian Brain

A research team led by Shujia Zhu from the Chinese Academy of Sciences’ (CAS) Center for Excellence in Brain Science and Intelligence Technology and Yang Li from the Shanghai Institute of Materia Medica of CAS examined the architecture and assembly of endogenous N-methyl-ᴅ-aspartate receptors (eNMDARs) in the cerebral cortex and hippocampus of adult mammals in a study published in Cell on January 23rd, 2025.

27 Jan 2025