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The Role of DNA Repair Pathways in Antibody Somatic Hypermutation

In a recent online publication in SCIENCE CHINA Life Sciences, researchers from the laboratory of Leng-Siew Yeap at the Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine published a review article entitled "Molecular Mechanisms of DNA Lesion and Repair During Antibody Somatic Hypermutation". This review comprehensively summarizes the mechanisms involved in the generation of antigen-specific diversified antibodies, with a particular focus on the mechanisms that generate high-frequency point mutations and low-frequency deletions and insertions (indels) in antibody genes.

22 Aug 2024

New Approach for Targeted Genome Editing in Wild Populations

Researchers from Macquarie University and the California Institute of Technology have discovered a novel method that, when published in Nature Communications on August 13th, 2024, might make it easier and more controllable for scientists to modify the genetic composition of wild populations than when using gene drives.

14 Aug 2024

Multispecies Transmission of Avian Flu Virus Includes Dairy Cattle, Cats, and Raccoons

A viral spillover of the highly pathogenic avian influenza virus belonging to the hemagglutinin 5 neuraminidase 1 (H5N1) 2.3.4.4b clade among herds of dairy cattle.

5 Aug 2024

New Insights into the Mechanisms of Gene Misbehavior

Researchers have discovered that a startlingly widespread occurrence in the healthy human population is "gene misbehavior," or the state in which genes are active when they should be inactive.

25 Jul 2024

New RNA Sequencing Dataset Reveals Genetic Diversity Across Global Populations

An open-access dataset of RNA sequences from lymphoblastoid cell lines of 731 individuals spanning 26 populations and five continental groups.

24 Jul 2024

Few Chicken Products with Highly Virulent Salmonella Strains Responsible for Most Illnesses

Raw poultry is one of the main causes of Salmonella poisoning, which affects thousands of people in the U.S. every year. A new study from the University of Illinois Urbana-Champaign shows that few products with high levels of very virulent Salmonella strains are responsible for most of the illnesses from raw chicken parts.

16 Jul 2024

3D-Printed Device Transforms Blood Conductivity Measurement with AI Precision

A novel lab-on-a-chip device consisting of a portable millifluidic nanogenerator that can gauge blood conductivity at low frequency.

9 Jul 2024

Study Finds Bacteria in Commercial Tattoo and Permanent Makeup Inks

Commercial tattoo and permanent makeup inks have been found to contain both aerobic and anaerobic bacteria by researchers.

3 Jul 2024

Study Offers Insights Genetic Variants Influencing Pubertal Timing

Genes can indirectly influence the age at which girls have their first period by accelerating weight gain in childhood, a known risk factor for early puberty, a Cambridge-led study has found.

2 Jul 2024

TATSI Technology Enhances Crop Genome Editing with Transposase-Assisted Integration

With the goal of reducing the time and cost it takes to bring an improved crop to the marketplace, research conducted in the laboratory of Keith Slotkin, PhD, and his colleagues in the Plant Transformation Facility at the Donald Danforth Plant Science Center, was recently published in the scientific journal.

1 Jul 2024

Enhanced Maize Transformation Efficiency Through Ternary Vectors and Morphogenic Regulators

Maize is one of the classical model organisms for genetic research. However, the low transformation frequency remains an important bottleneck for many gene-editing applications.

25 Jun 2024

Ultrasound-Triggered Nanodroplets for Targeted Drug Delivery

Conventional drug delivery is often like cracking a nut with a sledgehammer. Whether the drug is swallowed, injected, inhaled, or absorbed through the skin, it ultimately diffuses to most parts of the body, including those where it isn’t needed – or where it even might cause harm.

22 Jun 2024

Stick Insect Research Sheds Light on Evolutionary Dynamics

A long-standing debate among evolutionary scientists goes something like this: Does evolution happen in a predictable pattern or does it depend on chance events and contingency?

27 May 2024

Researchers Develop Strategy to Replace Diseased Blood System Affected by Leukemia

Researchers have developed an approach to "deleting" a blood system affected by leukemia while simultaneously building up a new, healthy system with donor blood stem cells.

24 May 2024

Sonification Reveals Hidden Patterns in Protein Folding Dynamics

By converting their data into sounds, scientists discovered how hydrogen bonds contribute to the lightning-fast gyrations that transform a string of amino acids into a functional, folded protein.

21 May 2024

Herpes Gene Therapy Achieves 90% Viral Reduction in Pre-Clinical Studies

Researchers at Fred Hutch Cancer Center have found in pre-clinical studies that an experimental gene therapy for genital and oral herpes removed 90% or more of the infection and suppressed how much virus can be released from an infected individual, which suggests that the therapy would also reduce the spread of the virus.

16 May 2024

Frequency News and Research

The Role of DNA Repair Pathways in Antibody Somatic Hypermutation

New Approach for Targeted Genome Editing in Wild Populations

Multispecies Transmission of Avian Flu Virus Includes Dairy Cattle, Cats, and Raccoons

New Insights into the Mechanisms of Gene Misbehavior

New RNA Sequencing Dataset Reveals Genetic Diversity Across Global Populations

Few Chicken Products with Highly Virulent Salmonella Strains Responsible for Most Illnesses

3D-Printed Device Transforms Blood Conductivity Measurement with AI Precision

Study Finds Bacteria in Commercial Tattoo and Permanent Makeup Inks

Study Offers Insights Genetic Variants Influencing Pubertal Timing

TATSI Technology Enhances Crop Genome Editing with Transposase-Assisted Integration

Enhanced Maize Transformation Efficiency Through Ternary Vectors and Morphogenic Regulators

Ultrasound-Triggered Nanodroplets for Targeted Drug Delivery

Stick Insect Research Sheds Light on Evolutionary Dynamics

Researchers Develop Strategy to Replace Diseased Blood System Affected by Leukemia

Sonification Reveals Hidden Patterns in Protein Folding Dynamics

Herpes Gene Therapy Achieves 90% Viral Reduction in Pre-Clinical Studies

Revealing the Genetic Mechanisms Driving SARS-CoV-2 Variants

SARS-CoV-2 Variants Detected in Flood-Control Channels Near Homeless Encampments

AI Predicts Multiple Protein Shapes, Boosting Drug Development

The Secrets of Toxic Algal Blooms: A Deep Dive into Prorocentrum cordatum's Cell Biology

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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