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How Does DNA Unwind? Study Explores Helicase Mechanisms In DNA Replication

This study reveals how SV40 helicase unwinds DNA, highlighting ATP hydrolysis's role in translocation and offering insights into viral replication mechanisms.

28 Mar 2025

How Drug-Resistant Bacteria Use Antimicrobial Tools to Outcompete Others

A drug-resistant type of bacteria that has adapted to health care settings evolved in the past several years to weaponize an antimicrobial genetic tool, eliminating its cousins and replacing them as the dominate strain.

24 Mar 2025

UV Light Reshapes 3D Genome Structure, Altering DNA Repair and Gene Activity

Research shows UV radiation modifies 3D genome structure, affecting DNA damage response and gene activity, offering insights for cancer prevention strategies.

24 Mar 2025

AGD Initiative Drives Progress in Drug Discovery with Sequencing of 250,000 Whole Genomes

Nashville Biosciences LLC (NashBio), a leading clinical and genomic data company and wholly owned subsidiary of Vanderbilt University Medical Center, and global DNA sequencing giant Illumina Inc. today announced that 250,000 whole genomes have been sequenced for the Alliance for Genomic Discovery (AGD) initiative.

22 Mar 2025

New Resource for Improving Pistachio Quality

California generates around $3 billion in economic value from the production of 99% of the country's pistachios. The absence of a high-quality DNA map, however, has contributed to the minor understudies of pistachios.

21 Mar 2025

Bioengineering a Luminous Biosensor for Aberrant DNA Detection

Cells contain a DNA sensor called cGAS, which alerts the immune system to viral and bacterial infections, cell death, and cancer-related transformations.

20 Mar 2025

AI Revolutionizes Cell Analysis for Personalized Cancer Treatment

A groundbreaking artificial intelligence (AI)-driven neural network has been developed to swiftly analyze and interpret millions of cells from patient samples, enabling predictions of molecular alterations within tissues.

19 Mar 2025

Scientists Unlock Genetic Secrets of Wild Barley to Improve Crop Yields

An international team of scientists from Australia and China has unveiled the first chromosome-scale genome of a wild barley species, with their findings offering direct implications for more sustainable agriculture and significant yield improvements for Australian grain production.

17 Mar 2025

Extrachromosomal DNA Discovered as a Hidden Factor in Pancreatic Cancer Survival

Pancreatic cancer is one of the deadliest cancers worldwide, with a five-year survival rate of 13%.

14 Mar 2025

Study Reveals How DNA Reorganization Helps Cells Survive UV Damage

Ultraviolet (UV) radiation from the sun is a well-known cause of DNA damage, which can lead to diseases like skin cancer.

13 Mar 2025

Machine Learning Addresses Ancestral Diversity in Disease Prediction

To ensure that medical genetic research better represents and benefits people from all backgrounds, researchers at the University of Florida are filling a crucial gap in the field.

11 Mar 2025

Cryo-EM Reveals 3D Structure of Nipah Virus RNA Polymerase

The replication of the Nipah virus's genetic material in infected cells has been demonstrated for the first time by researchers from the Max Planck Institute (MPI) for Multidisciplinary Sciences and the University Medical Center Göttingen (UMG). In humans, the virus can cause fatal encephalitis.

11 Mar 2025

Lack of Genetic Diversity in Reference Groups Leads to Misdiagnoses

A new study has uncovered that a gene variant common in Oceanian communities was misclassified as a potential cause of heart disease, highlighting the risk of the current diversity gap in genomics research which can pose a greater risk for misdiagnosis of people from non-European ancestries.

8 Mar 2025

Genomics can Transform Care for Children with Rare Diseases

A simple genomics blood test could improve treatment and care for childhood epilepsy, but more investment is needed to make access fair and securely join up the data, finds a new study involving researchers at University College London (UCL) and Great Ormond Street Hospital for Children (GOSH).

8 Mar 2025

Mapping DNA's Hidden Switches: A Methylation Atlas

A new study, led by PhD student Jonathan Rosenski under the guidance of Prof. Tommy Kaplan from the School of Computer Science and Engineering and Prof. Yuval Dor from the Faculty of Medicine at the Hebrew University of Jerusalem and Hadassah Medical Center, has been published in Nature Communications, presenting the first comprehensive atlas of allele-specific DNA methylation across 39 primary human cell types.

7 Mar 2025

Cryo-ET Reveals Retrotransposon Replication Inside Cells

An arms race is occurring within human cells: Transposons, also known as jumping genes or mobile genetic elements, can replicate and reintegrate themselves into the genome, posing a threat to genomic integrity by inducing DNA rearrangements and mutations.

6 Mar 2025

Arab Pangenome Reference Provides New Path for Advancing Precision Medicine

Creation of a comprehensive genetic representation for more than 2.5 billion people across the Middle East and South Asia could make a major contribution towards advancing precision medicine, a publication in Nature Medicine reveals.

5 Mar 2025

New CRISPR Method Enhances Surveillance of Antibiotic Resistance in Wastewater

Antibiotic resistance is a global concern that threatens our ability to prevent and treat bacterial infections in humans and animals.

4 Mar 2025

New ctDNA Model Enhances Metastatic Cancer Surveillance

In metastatic cancer surveillance, monitoring the actual concentrations of circulating tumor DNA (ctDNA) may be critical. Researchers showed that absolute ctDNA concentration thresholds can be defined to rule out or predict impending cancer progression.

25 Feb 2025

Bacterial Cellulose Triggers Plant Regeneration Mechanism

A groundbreaking study, co-led by researchers from the Center for Plant Biotechnology and Genomics (CBGP) and Centre for Research in Agricultural Genomics (CRAG), has elucidated the mechanism by which bacterial cellulose mediates plant tissue regeneration.

13 Feb 2025