Progenitor Cells News and Research

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Extended generation of blood cells in wild-type animals from pluripotent stem cells

Cells present in the blood like red blood cells, immune cells, and other crucial cell types are renewed continually from stem cells, the alleged hematopoietic stem and progenitor cells (HSPCs).

17 Feb 2023

Reversal of ADAR1 hyper-editing with small molecule inhibitor

Researchers at University of California San Diego School of Medicine, Sanford Stem Cell Institute and Moores Cancer Center report that a late-stage, pre-clinical small molecule inhibitor, called rebecsinib, reverses malignant hyper-editing by an inflammation-induced protein isoform, known as ADAR1 p150.

17 Feb 2023

Role of clonal hematopoiesis as a broad driver of atherosclerosis

A group at the Centro Nacional de Investigaciones Cardiovasculares (CNIC), collaborating with institutions in the USA, has shown that acquired mutations in the gene encoding the protein p53 contribute to the onset of atherosclerotic cardiovascular disease.

18 Jan 2023

Molecular regulation underlying emergency hematopoiesis uncovered

If the body’s emergency hematopoiesis program activates, it signifies an alert state of the immune system and serves two functions: In comparison to “normal mode” hematopoiesis, the emergency program results in enhanced replacement of immune cells consumed during infections or inflammations.

12 Dec 2022

Using nanotechnology and magnetic manipulations to bioengineer 3D neural networks

Neurons are the fundamental units of the brain and nervous system, the cells responsible for receiving sensory input from the external world, for sending motor commands to our muscles, and for transforming and relaying the electrical signals at every step in between.

30 Nov 2022

RNA-edited regions in brain shed light on neurodevelopment and disease

Numerous sites in the brain where RNA is altered over the course of a person’s lifespan through a process known as adenosine-to-inosine (A-to-I) editing have been identified by Mount Sinai researchers.

3 Nov 2022

Researchers reveal key developmental difference between the brains of modern humans and Neanderthals

AZoLifesciences speaks to Dr. Anneline Pinson and Prof. Dr. Wieland B. Huttner from The Max Planck Institute of Molecular Cell Biology and Genetics about their latest research which found a greater neuron production in the frontal lobe during brain development in modern humans than Neanderthals, due to the change of a single amino acid in the protein TKTL1.

From The Max Planck Institute 20 Sep 2022

Spatial transcriptomic data highlights the features of the axolotl brain

The first spatiotemporal cellular atlas of axolotl (Ambystoma mexicanum) brain growth and regeneration, created by a multi-institute research team under the direction of BGI-Research, reveals how brain damage may recover itself.

8 Sep 2022

Scientists discover latent stem cells that respond to injury in the central nervous system of mice

Scientists at the Francis Crick Institute have identified a group of latent stem cells that respond to injury in the central nervous system of mice. If a similar type of cell exists in humans, they could offer a new therapeutic approach to treat brain and spinal cord injuries.

23 Aug 2022

Novel molecule probe accomplishes live B cells distinction over T cells

The human body is regularly exposed to bacteria, parasites, viruses, and other pathogens, making the immune system vital for survival.

25 Jul 2022

Research identifies the main gene that causes developmental disability syndrome

A single gene that was previously discovered to be the main factor in a rare disease associated with epilepsy, autism, and developmental delay has been named as a key player in the development of healthy neurons.

1 Jul 2022

Researchers conduct a comprehensive survey of the aging epigenome across the chromatin hierarchy

Highly structured chromatin encodes the program of life with only one set of genes in the core of every cell. Since various genes are stimulated at different periods of life while staying silent elsewhere, this is feasible. Some genes from a former life stage are hidden deep within the nuclear perimeter, while others manage to break out.

1 Jun 2022

Researchers shed light on development and treatment of brain diseases

It is highly regulated what goes into the brain and what does not. The phagocytes that encapsulate the blood arteries in the brain and maintain the blood-brain barrier have been examined by researchers at the University of Freiburg’s Faculty of Medicine.

25 Apr 2022

Progenitor Cells News and Research

Extended generation of blood cells in wild-type animals from pluripotent stem cells

Reversal of ADAR1 hyper-editing with small molecule inhibitor

Role of clonal hematopoiesis as a broad driver of atherosclerosis

Molecular regulation underlying emergency hematopoiesis uncovered

Using nanotechnology and magnetic manipulations to bioengineer 3D neural networks

RNA-edited regions in brain shed light on neurodevelopment and disease

Researchers reveal key developmental difference between the brains of modern humans and Neanderthals

Spatial transcriptomic data highlights the features of the axolotl brain

Scientists discover latent stem cells that respond to injury in the central nervous system of mice

Novel molecule probe accomplishes live B cells distinction over T cells

Research identifies the main gene that causes developmental disability syndrome

Researchers conduct a comprehensive survey of the aging epigenome across the chromatin hierarchy

Researchers shed light on development and treatment of brain diseases

Bone growth protein may help treat newborns with rare genetic lung condition

Scientists reveal the origins and provide a detailed ID card of pancreatic endocrine stem cells

Bioprinting bone along with two growth factor encoding genes improves bone repair

Biologists unravel the mystery behind nuclear anomaly in blood cancer cells

Researchers discover new type of cell that may play a key role in human lung diseases

Researchers discover abnormal gene mutations that lead to cancer development

One-time infusion of stem cells from bone marrow improves sepsis survival in mice

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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