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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Novel Approach to Combat Protein-Related Diseases

Researchers from Mainz and Leiden universities have devised a simple model system that can be used to break down fibrils, the cause of several diseases like Alzheimer's and Parkinson's disease, into their constituent single units or liquid droplets.

14 Nov 2024

Cow Digestive Enzyme Shown to Break Down Tough Bacterial Biofilms

Most of the disease-causing bacteria secrete matrix-like layers around themselves called biofilms. These biofilms act as thick barriers limiting the entry of drugs and helping the bacteria become resistant to antibiotics.

12 Nov 2024

Groundbreaking Research Sheds Light on Mutant RAS and Cancer Progression

Researchers at the National Institutes of Health (NIH) and their collaborators have discovered a new way in which RAS genes, which are commonly mutated in cancer, may drive tumor growth beyond their well-known role in signaling at the cell surface.

12 Nov 2024

New Strategy Reinvigorates Exhausted T Cells to Fight Cancer

As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells -; which have lost their cancer-fighting oomph -; consume this lactic acid, which further saps their energy, according to new research from the University of Pittsburgh and UPMC Hillman Cancer Center.

11 Nov 2024

Researchers Provide Genetic Diagnosis for 30 Long-Term Undiagnosed Cases

An international team of researchers has provided a genetic diagnosis for 30 individuals whose condition was undiagnosed for years despite extensive clinical or genetic testing.

11 Nov 2024

New Insights into the Molecular Basis of Mitochondrial Diseases

A significant finding about the energy production process of human cells has been made by researchers at the Karolinska Institute's Department of Cell and Molecular Biology.

11 Nov 2024

SARS-CoV-2 Outwits Immune System, Prolonging Infection

SARS-CoV-2 inhibits the function of the complement system, a crucial element of early antiviral immunity, by hijacking three crucial host proteins, according to research from the Medical Universities of Vienna and Innsbruck.

11 Nov 2024

Domainex Integrates Nuclera’s eProtein Discovery System to Enhance Drug Discovery Services

Nuclera, the biotechnology company accelerating protein expression and optimization through its benchtop eProtein Discovery™ system, and Domainex, a multi-award winning provider of integrated, pre-clinical drug discovery services, today announced that Domainex is the first contract research organization (CRO) to have installed the eProtein Discovery system and offer protein production services using the technology.

9 Nov 2024

CRISPR Reveals Hidden Functions of Noncoding RNA

Genes contain instructions for protein production, with the central dogma of biology stating that this information flows from DNA to RNA to proteins.

8 Nov 2024

Scientists Discover a Hidden Ally in the Fight Against Cancer

An intracellular sensor that tracks the quality of so-called MHC-I molecules which aid the immune system in identifying and eliminating dangerous cells, including tumor cells has been discovered by a global team headed by Goethe University Frankfurt.

7 Nov 2024

Study Reveals How Plants Override Genetic Instructions Through DNA Duplication

Biologists at Washington University in St. Louis have discovered the origin of a curious duplication that gives plants multiple ways to override instructions that are coded into their DNA.

7 Nov 2024

Astrocytes Play Key Role in Memory Storage and Recall, Study Shows

A study published in Nature by researchers at Baylor College of Medicine changes the way we understand memory.

7 Nov 2024

How Neuroimmune Cells Modulate Immune Responses and Neuroinflammation

The brain, traditionally considered an immune-privileged organ due to the blood-brain barrier (BBB), has its own sophisticated immune defense system.

7 Nov 2024

Study Reveals How Chronic Immune Signaling Can Promote Cancer

Along with defending against pathogens, the body's innate immune system helps to protect the stability of our genomes in unexpected ways -; ways that have important implications for the development of cancer, researchers at Memorial Sloan Kettering Cancer Center (MSK) are discovering.

6 Nov 2024

16 Types of Nerve Cells Found to be Involved in Human Sense of Touch

No less than 16 different types of nerve cells have been identified by scientists in a new study on the human sense of touch.

6 Nov 2024

APOE4 and Microglia Together Drive Alzheimer's Protein Deposits

In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein-;the most important genetic risk factor for Alzheimer's disease-;the same cells cause harmful inflammation and clumps of misfolded proteins, according to a new study by scientists at Gladstone Institutes.

5 Nov 2024

Novel Approach to Isolating and Quantifying EV Cargo for Disease Diagnosis

Parkinson's disease (PD) and Alzheimer's disease (AD) are examples of brain illnesses that begin to develop in patients far earlier than the onset of their initial clinical symptoms.

4 Nov 2024

3D Tumor Microenvironment Model Highlights Role of Ischemia and Acidification in Cancer Spread

Developed 3MIC model simulates tumor microenvironments, enabling direct observation of ischemic effects on cancer cell invasiveness and drug resistance.

4 Nov 2024

Innovative Insights into the Interplay Between Proteins and Small Molecules

With the support of a Maximizing Investigators' Research Award, or MIRA, from the National Institutes of Health, Michigan State University researcher Aleksandra Skirycz is making fundamental discoveries linked to the health and resilience of plants and animals.

4 Nov 2024