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"Cervix-on-a-Chip" Offers Promise for New Bacterial Vaginosis Treatments

Bacterial Vaginosis (BV) has been identified as one of the many unmet needs in women's health and affects more than 25% of reproductive-aged women.

3 Jun 2024

Protein SRSF1 Plays Unexpected Role in Unwinding Complex RNA Structures

RNA transcription is the genomic process in which a cell produces a duplicate of a gene's DNA sequence.

31 May 2024

Study Reveals How tRNA Modification Influences Malaria Drug Resistance

Researchers from the Antimicrobial Resistance (AMR) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, in collaboration with Massachusetts Institute of Technology (MIT), Columbia University Irving Medical Center (CUIMC), and Nanyang Technological University, Singapore (NTU Singapore), have discovered a link between malaria parasites’ ability to develop resistance to antimalarial drugs – specifically artemisinin (ART) – through a cellular process called transfer Ribonucleic acid (tRNA) modification.

20 May 2024

New Insights Into Centromere Structure: Two Subdomains Revealed

Researchers from the Kops group in collaboration with researchers from the University of Edinburgh, made a surprising new discovery in the structure of the centromere, a structure that is involved in ensuring that chromosomes are segregated properly when a cell divides.

14 May 2024

Glutamate tRNA Fragments Play Key Role in Brain Aging and Alzheimer's Disease

A significant research paper published in the journal Cell Metabolism by the team of Prof. LIU Qiang at the University of Science and Technology of China (USTC) reveals the critical role of glutamate tRNA fragments in brain aging and Alzheimer's disease.

14 May 2024

Deep Proteomic Analysis Unveils Molecular Changes in Skeletal Muscle with Aging and Resistance Training

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 8, entitled, "A novel deep proteomic approach in human skeletal muscle unveils distinct molecular signatures affected by aging and resistance training."

2 May 2024

New Organoid Model Offers Opportunities to Study Thymus Function

Researchers from the Organoid group have developed a new organoid model that can be used to study the thymus.

30 Apr 2024

Researchers Identify Link Between Mitochondrial Depletion and Protein Build-Up in Neurons

Researchers from Tokyo Metropolitan University have identified how proteins collect abnormally in neurons, a feature of neurodegenerative diseases like Alzheimer's.

22 Apr 2024

Protein TRBP's Regulatory Role in Immune Response to Viral Infections Uncovered

Researchers have revealed the regulatory mechanism of a specific protein that plays a key role in balancing the immune response triggered by viral infections in mammal cells.

22 Apr 2024

Leveraging the Materiobiology Approach to Design Biomaterials for Aged Bone Repair

In the elderly, a multitude of factors contribute to diminished bone regeneration capabilities, including a reduction in the self-renewal and differentiation abilities of mesenchymal stem cells, an excessive accumulation of inflammatory signals, compromised blood vessel regeneration capacity, an imbalance between bone anabolism and catabolism, and inadequate bone innervation.

13 Apr 2024

Eleven New Trichoderma Species Discovered in Chinese Soil and Plant Samples

Trichoderma spp. are globally distributed and are considered significant fungal resources. They are widely studied and applied due to their economic and ecological importance, offering numerous benefits, such as producing enzymes and antibiotics, aiding in plant growth, and protecting them from pathogens.

2 Apr 2024

Multi-Tailed Strucrure Expands the Horizons of mRNA Therapeutics

Messenger RNA (mRNA) made its big leap into the public limelight during the pandemic, thanks to its cornerstone role in several COVID-19 vaccines

25 Mar 2024

DNA Origami Revolutionizes Cancer Immunotherapy: The DoriVac Breakthrough

Therapeutic cancer vaccines are a form of immunotherapy in the making that could not only destroy cancer cells in patients, but keep a cancer from coming back and spreading.

15 Mar 2024

The Impact of Catalysis for Site-Specific Protein Modification

As they recently reported in the journal Nature Chemistry, Boston College researchers have developed a new tool that can be used to develop novel biotherapeutics and protein-based research tools: the ability to precisely modify proteins using a mild charge of electricity.

6 Mar 2024

The Role of RNA Modifications in Stress Granule Dynamics

An intriguing finding regarding how human cells protect themselves under stressful conditions has been revealed in a recent study conducted by an international research team. According to the research, a little genetic alteration known as ac4C serves as an essential defender by assisting cells in producing stress granules, which are units of defense.

28 Feb 2024

Scientists Develop First Full Model of Early Human Central Nervous System with Stem Cells

The first stem cell culture method that produces a full model of the early stages of the human central nervous system has been developed by a team of engineers and biologists at the University of Michigan, the Weizmann Institute of Science, and the University of Pennsylvania.

27 Feb 2024

Decoding the Secrets of Ribosome Recycling at the Endoplasmic Reticulum

Researchers from Stanford University and LMU have uncovered how cells renew their endoplasmic reticulum’s protein factories.

26 Feb 2024

Herts Awarded Its Biggest Ever Research Grant to Develop Biodetection Technologies Against Harmful, Airborne Pathogens

The University of Hertfordshire has been awarded £13.5million – its biggest ever research grant – to expand and progress its sector-leading, research-led development of biodetection technologies against harmful, airborne pathogens.

17 Jan 2024

Messenger RNA Therapy Could be Used to Correct Rare Liver Genetic Disease

By exploiting the technology used in Covid-19 vaccines, a team led by UCL, King's College London and Moderna scientists has created an effective therapy for a rare disease, in a study in mice, demonstrating the technology's potential therapeutic use in people.

16 Jan 2024

A Dihydrofolate Reductase Single-Domain Protein Catenane

Professor Wen-Bin Zhang of the College of Chemistry and Molecular Engineering at Peking University and the Beijing Academy of Artificial Intelligence, along with Dr. Jing Fang of the same institution, are leading the study.

2 Jan 2024