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Study identifies genetic mutation in the SPTSSA gene as cause of Hereditary Spastic Paraplegia

A genetic mutation in the SPTSSA gene is identified as the cause of Hereditary Spastic Paraplegia, a rare disease that causes progressive weakness, stiffness and spasticity in the lower extremities, according to a study, "SPTSSA variants alter sphingolipid synthesis and cause a complex hereditary spastic paraplegia," published in Brain on on Jan. 30.

1 Feb 2023

Marine plankton samples can help understand the link between ocean pollution and chronic illnesses

Using samples from an almost century-old, ongoing survey of marine plankton, researchers at University of California San Diego School of Medicine suggest that rising levels of manmade chemicals found in parts of the world's oceans might be used to monitor the impact of human activity on ecosystem health, and may one day be used to study the connections between ocean pollution and land-based rates of childhood and adult chronic illnesses.

9 Jan 2023

Unique combination of transcription factors trigger cell regeneration in zebrafish

Scientists at the National Institutes of Health have identified a particular protein network required for cell regeneration to restore hearing in zebrafish.

From National Human Genome Research Institute (NHGRI) 15 Sep 2022

CNIC study uncovers a nuclear import mechanism essential for organ growth and development

Scientists at the Centro Nacional de Investigaciones Cardiovasculares have identified a nuclear import mechanism essential for organ growth and development. Manipulation of this mechanism has potential applications in the control of organ growth and organ regeneration.

4 Mar 2022

YME1L protein responsible for balancing the conversion of brain's neural stem cells

Researchers at the University of Cologne have discovered that the protein YME1L regulates the production of new nerve cells and the maintenance of neural stem cells in the adult brain.

16 Feb 2022

New gene therapy approach may help treat a wide variety of electrical heart diseases

Biomedical engineers at Duke University have demonstrated a gene therapy that helps heart muscle cells electrically activate in live mice.

7 Feb 2022

Exposure to phthalates may alter a hormone needed to sustain a healthy pregnancy

Exposure to phthalates-; a group of chemicals found in everything from plastics to personal care products to electronics-; may disrupt an important hormone needed to sustain a healthy pregnancy, according to a Rutgers study.

13 Jan 2022

Researchers develop new method to detect the onset of blood damage at sublethal stage

Red blood cells (RBCs) or erythrocytes are constantly exposed to a "shearing stress" during their circulation in the body. This stress is usually mild and the RBCs are flexible enough to accommodate shape changes in response to it.

17 Dec 2021

Study reveals the biochemistry of long-term memory consolidation

Scientists from Tokyo Metropolitan University recently gained a deeper understanding of the biochemistry of long-term memory.

14 Dec 2021

Study uncovers a protein that indicates whether emotional memories can be changed

Researchers have discovered that a particular protein can be used as a brain marker to indicate whether emotional memories can be changed or forgotten.

5 Oct 2021

Researchers generate cartilage tissue from embryonic stem cells

Scientists from the University of Southampton have identified a novel means to create human cartilage tissue from stem cells.

1 Oct 2021

Research finds an increase in prenatal cannabis usage

Kaiser Permanente analyzed more than 100,000 pregnancies and identified that there was a 25% increase in the rate of cannabis use early in pregnancy.

1 Oct 2021

Gene expression changes help understand the mechanism behind noise-induced hearing loss

A growing number of people are suffering from hearing loss due to exposure to loud noises from heavy machinery, concerts, or explosions. As a result, scientists have been working to understand the mechanism behind how the damage to hearing actually occurs.

30 Sep 2021

Western high-fat diet can increase the risk of painful conditions

A typical Western high-fat diet can increase the risk of painful disorders common in people with conditions such as diabetes or obesity, according to a groundbreaking paper authored by a team led by The University of Texas Health Science Center at San Antonio, also referred to as UT Health San Antonio.

24 Jun 2021

Novel protein interactions aid in the recovery process of brain damage

Patients suffering from brain damage largely depend on rehabilitation therapy for recovery, because no other effective treatment options are available.

21 Jun 2021

Cell adaptation to adverse conditions could differentiate survivors and non-survivors of critical illness

Creating the best conditions for cells to make energy and survive critical illness is a challenge little understood in modern medicine.

27 Apr 2021

3D biomaterial helps implanted stem cells stick around to reverse arthritis

A 3D biomaterial scaffold design to slowly release stem cells has worked to ensure implanted stem cells stick around to relieve pain and reverse arthritis in mice knee joints.

19 Apr 2021

Researchers identify gene variant associated with childhood asthma

Researchers at Henry Ford Health System, as part of a national asthma collaborative, have identified a gene variant associated with childhood asthma that underscores the importance of including diverse patient populations in research studies.

1 Mar 2021

Patients' own stem cells can be used to heal injured spinal cord

Intravenous injection of bone marrow derived stem cells (MSCs) in patients with spinal cord injuries led to significant improvement in motor functions, researchers from Yale University and Japan report Feb. 18 in the Journal of Clinical Neurology and Neurosurgery.

23 Feb 2021

New tool reveals potentially risky DNA alterations at site of CRISPR gene repair

Scientists have developed an affordable, downloadable app that scans for potential unintended mistakes when CRISPR is used to repair mutations that cause disease.

12 Feb 2021