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Global Effort Maps Genetic Makeup of Lyme Disease Bacteria

A team led by CUNY Graduate Center biologists has produced a genetic analysis of Lyme disease bacteria that may pave the way for improved diagnosis, treatment, and prevention of the tick-borne ailment.

16 Aug 2024

Researchers Uncover Role of OpgH in Bacterial Cell Shape

In what they labeled a "surprising" finding, Johns Hopkins Medicine researchers studying bacteria from freshwater lakes and soil say they have determined a protein's essential role in maintaining the germ's shape. Because the integrity of a bacterial cell's "envelope" or enclosure is key to its survival, the finding could advance the search for new and better antibiotics.

16 Aug 2024

New Insights into Memory Formation and Modification

The ability to turn experiences into memories allows us to learn from the past and use what we learned as a model to respond appropriately to new situations. For this reason, as the world around us changes, this memory model cannot simply be a fixed archive of the good old days.

16 Aug 2024

Two Genes Control Explosive Taste Bud Growth in Cavefish

Over thousands of years, cavefish evolved and lost their vision, earning the moniker "the blind cavefish," but some cavefish also developed an inordinate number of taste buds on the head and chin.

16 Aug 2024

Spontaneous Brain Activity Drives Early Neural Circuit Formation

In humans, the process of learning is driven by different groups of cells in the brain firing together. For instance, when the neurons associated with the process of recognizing a dog begin to fire in a coordinated manner in response to the cells that encode the features of a dog -; four legs, fur, a tail, etc. -; a young child will eventually be able to identify dogs going forward. But brain wiring begins before humans are born, before they have experiences or senses like sight to guide this cellular circuitry. How does that happen?

16 Aug 2024

Flavivirus Hijacks Importin-7 for Nuclear Transport and Replication

Viruses of the family Flaviviridae, including Japanese encephalitis virus (JEV), Dengue virus (DENV), Zika virus (ZIKV), West Nile virus (WNV), and Tick-borne encephalitis virus, are significant arthropod-borne pathogens.

15 Aug 2024

Study Uncovers Biomarkers for Low Muscle Mass, Offering Insights for Personalized Prevention

Machine learning models to analyze computed tomography (CT) images of the chest and a proteomics approach to determine blood protein biomarkers.

15 Aug 2024

New Approach for Targeted Genome Editing in Wild Populations

Researchers from Macquarie University and the California Institute of Technology have discovered a novel method that, when published in Nature Communications on August 13th, 2024, might make it easier and more controllable for scientists to modify the genetic composition of wild populations than when using gene drives.

14 Aug 2024

Astrocytes Emerge as Key Players in Brain Health and Development

Researchers at the Mechanobiology Institute (MBI) at the National University of Singapore (NUS) and Duke-NUS Medical School have uncovered a novel mechanism for reawakening dormant neural stem cells, which may lead to the development of new treatments for neurodevelopmental disorders like autism, cerebral palsy, and learning disabilities.

14 Aug 2024

Mechanical Manipulation of Stem Cells Promises New Treatments

New stem cell therapies may result from a novel method that McGill researchers have created for mechanically modifying stem cells, which has not yet reached its full therapeutic potential.

14 Aug 2024

Lipid Accumulation Linked to Senescence in Dopaminergic Neurons

A new research perspective was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 14 on July 19, 2024, entitled, "Lipid accumulation drives cellular senescence in dopaminergic neurons."

14 Aug 2024

Study Reveals Mechanisms Behind Lineage Restriction in Cell Development

A team of researchers from multiple institutions including the University of Chicago and VectorBuilder, has made a significant breakthrough in the understanding of lineage restriction, a biological phenomenon foundational to multicellular lifeforms as it secures the functional identities of the myriad cell types in the body.

14 Aug 2024

Driving Support for Pharmaceutical Testing Through Continuous Innovation

In this interview, Kyle James from ERWEKA highlights the company's commitment to supporting pharmaceutical sciences through advanced equipment and continuous innovation.

From ERWEKA 14 Aug 2024

Brain's Co-Rippling Activity Sheds Light on Consciousness

For many years, researchers have been concentrating on how the brain organizes information into hierarchical structures, with distinct regions of the brain designated for distinct functions.

13 Aug 2024

New Breast Cell Atlas Enhances Understanding of Cancer Origins

Scientists at the Melvin and Bren Simon Comprehensive Cancer Center at Indiana University have finished the largest mapping of healthy breast cells to date.

13 Aug 2024

New Insights into How Cell Nuclei Shape Tissue Architecture During Development

In work conducted both at UC Santa Barbara and the Physics of Life Excellence Cluster of TU Dresden, biophysicist Otger Campàs and his research group have found that cell nuclei control the architecture and mechanics of eye and brain tissues during embryonic development.

13 Aug 2024

Discovery of Efficient Glycosyltransferases for Pterocarpan Glycoside Biosynthesis

A research team has identified two highly efficient glycosyltransferases, AmGT28 and AmGT44, from Astragalus membranaceus, which convert medicarpin to medicarpin 3-O-glucoside and show a preference for pterocarpans over isoflavonoids.

13 Aug 2024

Advancing Genome Visualization with CRISPR/Cas9 Technology in Live Cells

Understanding the spatiotemporal organization of the genome in the nucleus is crucial for advancing our knowledge of chromatin structure and its functional dynamics in both normal and diseased states.

13 Aug 2024

New AI Model Predicts Protein-DNA Binding Specificity with High Accuracy

A new artificial intelligence model developed by USC researchers and published in Nature Methods can predict how different proteins may bind to DNA with accuracy across different types of protein, a technological advance that promises to reduce the time required to develop new drugs and other medical treatments.

12 Aug 2024

Scientists Discover a New Mechanism for Epithelial Tissue Development

How three-dimensional tissue forms emerge during animal development is one of the fundamental questions in biology and biophysics that remains unanswered.

12 Aug 2024