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Research reveals how RNA elements control cleavage activity of DICER enzyme in pre-miRNA and shRNAs

A research team led by scientists from the Hong Kong University of Science and Technology has revealed how secondary structure RNA elements control the cleavage activity of the DICER enzyme in both pre-miRNA and short-hairpin RNAs, improving the understanding of the DICER cleavage mechanism and providing a foundation for the design of accurate and efficient short-hairpin RNAs for gene-silencing.

20 Apr 2022

Rewiring the inner workings of leukemia cells to reverse drug resistance

Researchers from Barts Cancer Institute at Queen Mary University of London have identified a way to reverse resistance to a group of cancer drugs, known as kinase inhibitors, in leukemia cells.

20 Apr 2022

Cryo-EM reveals the structure of fermentation enzyme phosphoketolase

Pharmaceuticals, plastics, and other industries use enzymes to help synthesize molecular feedstocks.

19 Apr 2022

A new breakthrough in the quest to improve photosynthesis in certain crops

A Cornell University study describes a breakthrough in the quest to improve photosynthesis in certain crops, a step toward adapting plants to rapid climate changes and increasing yields to feed a projected 9 billion people by 2050.

19 Apr 2022

Researchers identify a way to accelerate "handbrake" immune cells to remove disease faster

Researchers at WEHI have discovered a mechanism to boost immune cells, allowing them to remove disease and infections more quickly.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 15 Apr 2022

Max Planck researchers reveal the structure of kinetochore corona

During cell division in a mother cell, the 23 chromosomes that carry the human genome must be first copied and later delivered to two newly forming daughter cells.

From The Max Planck Institute 11 Apr 2022

Rockefeller scientists reveal how a narrow-spectrum antibiotic selectively targets C. diff

Most antibiotics are double-edged swords. Besides killing the pathogen they are prescribed for, they also decimate beneficial bacteria and change the composition of the gut microbiome.

7 Apr 2022

Breakthrough discovery provides a desirable drug target to tackle metabolic diseases

In a breakthrough discovery, scientists from The University of Texas Health Science Center at San Antonio today reported that inhibiting a liver enzyme in obese mice decreased the rodents' appetite, increased energy expenditure in adipose (fat) tissues and resulted in weight loss.

6 Apr 2022

Powerhouse-pruning protein may be a sound target to help trigger new blood vessel growth

A protein that helps keep our cell powerhouses working at a premium appears to also help make energy rapidly available when it's time to make new blood vessels.

5 Apr 2022

ATM kinase inhibitor combines with target therapies to wipe out cancer cells

While cancer therapies that target specific genes or disease pathways might prolong life span, they can also result in highly resistant tumors when tiny reservoirs of cancer cells survive therapy, develop, and spread.

1 Apr 2022

Researchers discover a novel pathway for DNA transfer in the tumor microenvironment

Scientists from the University of Notre Dame have found a new way for tumor cells to transmit genetic material to other cells in their microenvironment, allowing cancer to spread.

1 Apr 2022

Study reveals novel mechanism used by infectious bacteria to survive stressful situations

A new study led by researchers at University of Utah Health details a novel mechanism that infectious bacteria use to quickly adjust to environmental stress. The discovery could help explain why certain types of common infections-;such as urinary tract and bloodstream infections like sepsis- are hard to get rid of.

From The University of Utah 24 Mar 2022

Enzyme News and Research

Research reveals how RNA elements control cleavage activity of DICER enzyme in pre-miRNA and shRNAs

Rewiring the inner workings of leukemia cells to reverse drug resistance

Cryo-EM reveals the structure of fermentation enzyme phosphoketolase

A new breakthrough in the quest to improve photosynthesis in certain crops

Researchers identify a way to accelerate "handbrake" immune cells to remove disease faster

Max Planck researchers reveal the structure of kinetochore corona

Rockefeller scientists reveal how a narrow-spectrum antibiotic selectively targets C. diff

Breakthrough discovery provides a desirable drug target to tackle metabolic diseases

Powerhouse-pruning protein may be a sound target to help trigger new blood vessel growth

ATM kinase inhibitor combines with target therapies to wipe out cancer cells

Researchers discover a novel pathway for DNA transfer in the tumor microenvironment

Study reveals novel mechanism used by infectious bacteria to survive stressful situations

Research reveals how a marine bacterium makes a potent anti-cancer molecule

Study shows how immune systems tune antibodies to fight against infection

Scientists discover new details on vital enzyme that allows for DNA sequencing

Interactions of marine microbes and minerals may have led to oxygen build up in the atmosphere

Researchers discover protein that turbocharges gene response

Yale researchers find a way to 'supercharge' tumor-attacking T cells

Proximity-dependent biotinylation helps analyze protein interaction

Discovery provides new insights into the understanding of tolerance to endotoxic death

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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