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Scientists Use Cell Density to Control Tissue Formation

Genes aren't the sole driver instructing cells to build multicellular structures, tissues, and organs.

20 Nov 2024

Magnesium-Focused Approach to Curbing Antibiotic Resistance

According to recent estimates, the number of fatal antibiotic-resistant illnesses is expected to increase significantly over the next 25 years.

18 Nov 2024

Unveiling the Mechanisms of Phenotypic Heterogeneity in M. tuberculosis

The only single-celled organism ever found to sustain a steady growth rate throughout its life cycle is the rod-shaped tuberculosis (TB) bacterium, which the World Health Organization has once again named the leading infectious disease killer worldwide.

18 Nov 2024

New Mechanism for Precise Protein Production Unveiled

A new process that is essential to the synthesis of cellular proteins has been discovered by an international research team.

15 Nov 2024

Study Shows How Genetic Variations Can Enhance Cancer Drug Effectiveness

By exploiting the genetic variation in cancer cells, an already approved cancer drug demonstrated enhanced effects against cancer cells in specific patient groups.

15 Nov 2024

AI Tool Predicts Gene Activity from Tumor Images to Guide Treatment

To determine the type and severity of a cancer, pathologists typically analyze thin slices of a tumor biopsy under a microscope.

15 Nov 2024

Unveiling the Clinical Significance of Microbial Load in Human Health

Scientists built a new machine-learning model to predict microbial load — the density of microorganisms in the guts — and used it to explain how microbial load plays an essential role in disease-microbiome relationships.

14 Nov 2024

Novel Approach to Combat Protein-Related Diseases

Researchers from Mainz and Leiden universities have devised a simple model system that can be used to break down fibrils, the cause of several diseases like Alzheimer's and Parkinson's disease, into their constituent single units or liquid droplets.

14 Nov 2024

Cow Digestive Enzyme Shown to Break Down Tough Bacterial Biofilms

Most of the disease-causing bacteria secrete matrix-like layers around themselves called biofilms. These biofilms act as thick barriers limiting the entry of drugs and helping the bacteria become resistant to antibiotics.

12 Nov 2024

Groundbreaking Research Sheds Light on Mutant RAS and Cancer Progression

Researchers at the National Institutes of Health (NIH) and their collaborators have discovered a new way in which RAS genes, which are commonly mutated in cancer, may drive tumor growth beyond their well-known role in signaling at the cell surface.

12 Nov 2024

New Strategy Reinvigorates Exhausted T Cells to Fight Cancer

As cancer cells grow, they pump out metabolic byproducts such as lactic acid into the tumor microenvironment. Exhausted T cells -; which have lost their cancer-fighting oomph -; consume this lactic acid, which further saps their energy, according to new research from the University of Pittsburgh and UPMC Hillman Cancer Center.

11 Nov 2024

Drug Adsorption on Nano-Plastics: Could Plastic Particles Reduce Antibiotic Efficacy?

Interactions between tetracycline and nano-plastics alter drug stability and bioavailability, raising concerns about antibiotic resistance in ecosystems.

11 Nov 2024

Innovative Biocatalysis Method Promises Faster, Greener Drug Manufacturing

Researchers have found a new way to use biocatalysis to improve the production of critical raw materials required for essential drugs, making the process quicker, more efficient, and environmentally friendly.

9 Nov 2024

Using Machine Learning to Understand Gene Interactions

By examining changes in gene expression, researchers gain insights into how cells operate at a molecular level, which can contribute to a better understanding of the onset of various diseases.

8 Nov 2024

UAB Develops a Polygenic Score to Predict Cancer Drug Resistance

In 1937, President Franklin Roosevelt signed the National Cancer Act, launching a nationwide effort to combat the disease.

8 Nov 2024

New Weapon in the Fight Against Antimicrobial Resistance

According to the Centers for Disease Control and Prevention, waterborne illnesses cost the healthcare system more than $3 billion a year and impact more than seven million Americans. However, not everyone is affected in the same way.

7 Nov 2024

Scientists Discover a Hidden Ally in the Fight Against Cancer

An intracellular sensor that tracks the quality of so-called MHC-I molecules which aid the immune system in identifying and eliminating dangerous cells, including tumor cells has been discovered by a global team headed by Goethe University Frankfurt.

7 Nov 2024

Gut Bacteria Influence Stress Responses Through Circadian Rhythms

A pioneering study has uncovered the vital role that gut microbiota plays in regulating stress responses by interacting with the body's circadian rhythms.

6 Nov 2024

APOE4 and Microglia Together Drive Alzheimer's Protein Deposits

In healthy brains, immune cells called microglia patrol for damage, clearing away debris and harmful proteins. But in the presence of the APOE4 protein-;the most important genetic risk factor for Alzheimer's disease-;the same cells cause harmful inflammation and clumps of misfolded proteins, according to a new study by scientists at Gladstone Institutes.

5 Nov 2024

Innovative Insights into the Interplay Between Proteins and Small Molecules

With the support of a Maximizing Investigators' Research Award, or MIRA, from the National Institutes of Health, Michigan State University researcher Aleksandra Skirycz is making fundamental discoveries linked to the health and resilience of plants and animals.

4 Nov 2024