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Prime Editing System Could Accelerate the Study of Cancer-Linked Mutations

Genomic studies of cancer patients have revealed thousands of mutations linked to tumor development.

12 May 2023

Argonne's Advanced Photon Source Helps Identify New Antibodies Against Coronaviruses

Results could speed development of new antivirals or vaccines that could counter many different coronavirus variants.

2 May 2023

Blocking Necroptosis Could Lead to the Inhibition of Cancer Metastasis

A new editorial paper was published in Oncotarget's Volume 14 on April 10, 2023, entitled, "Tumor necroptosis promotes metastasis through modulating the interplay between tumor and host immunity."

25 Apr 2023

Experts Unravel the Crystal Structure of CENP-E

Anticancer drugs are essential in cancer treatment, but their toxicity is not always restricted to cancer cells, resulting in serious side effects.

5 Apr 2023

Researchers Explain How a Single Mutation Causes Ataxia

Worldwide, only a handful of patients are known to suffer from episodic ataxia type 6, a neurological disease that causes transient loss of muscle control.

4 Apr 2023

Researchers uncover how DNA double-stranded breaks are repaired

A team of researchers from Michigan State University's College of Veterinary Medicine has made a discovery that may have implications for therapeutic gene editing strategies, cancer diagnostics and therapies and other advancements in biotechnology.

3 Mar 2023

Proteins’ movement and the spread of antibiotic resistance

Umeå University researchers have figured out how a particular type of protein travels during DNA replication. The discovery could affect the current understanding of how bacteria propagate antibiotic resistance genes.

30 Jan 2023

Potential to rectify various disease-causing mutations enhanced by CRISPR-based enzymes

Designing genome editing strategies for each patient’s mutation would be impractical and expensive because many genetic diseases are induced by diverse mutations spread across an entire gene.

18 Jan 2023

Structure of the complete virion of S. epidermidis–infecting phage revealed

Scientists from the University of Alabama at Birmingham used cryo-electron microscopy to reveal the structure of a bacterial virus in extraordinary detail.

20 Dec 2022

Preventing protein-protein interactions with a new tool

Proteins constantly interact with one another inside cells to perform various tasks. Blocking the binding of two or more proteins appears as a potential treatment for some diseases where these functions are altered.

1 Dec 2022

Revealing the unappreciated role of POLQ in responding to DNA replication stress

Researchers at the Francis Crick Institute, in partnership with Artios, have discovered how an enzyme involved in DNA repair (POLQ) becomes critical to the survival of some tumors when the cancer cells lose the ability to employ a more frequent way of DNA repair.

1 Dec 2022

Research could advance our understanding of evolution and the origins of cell motility

The origin of all biological movements, including walking, swimming, or flying, can be traced back to cellular movements; however, little is known about how cell motility arose in evolution.

1 Dec 2022

Enzymes hold the answer to understanding how DNA mutates

According to recent research from the University of Surrey, enzymes, which are essential for regulating how cells replicate in the human body, could be the very component that encourages DNA to spontaneously mutate, leading to potentially permanent genetic errors.

From University of Surrey 17 Nov 2022

Genetically modifying plant protein to yield more vegetable oil

At the Nanyang Technological University, Singapore (NTU Singapore), researchers have been successful in genetically modifying a plant protein that is accountable for oil accumulation in edible nuts and plant seeds.

From Nanyang Technological University Singapore (NTU Singapore) 11 Nov 2022

Carp virus provides significant insights into immunology

In an article published in the journal Nucleic Acids Research, the team led by Prof. Alain Vanderplasschen, a virologist and immunologist at the University of Liège, describes 10 years of research on how a carp virus uses a protein domain called Zalpha (Zα) to inhibit the host cell’s defense mechanisms.

26 Sep 2022

Novel means to prevent and treat gonorrhea

According to scientists from the Georgia State University’s Institute for Biomedical Sciences, producing a mutation that impedes the way the bacterial pathogen Neisseria gonorrhoeae transmits gonorrhea might provide a novel means to prevent and treat the disease.

26 Sep 2022

Study highlights retrotransposition in CRISPR gene therapy clinical trials

Worldwide clinical studies for gene therapy utilizing CRISPR/Cas9 gene editing are now underway for a number of disorders. A study from Boston Children’s Hospital that was released in Nature Communications on June 27th, 2022, alerts readers to a possible CRISPR editing risk that has not yet been identified.

8 Jul 2022