Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

New Study Identifies Aerobic Glycolysis Vital for Eye Development

According to a recent Northwestern Medicine study published in Nature Communications, aerobic glycolysis, the process by which cells convert glucose into lactate, is essential for eye development in mammals.

17 Jul 2023

Glutaminase 2 Plays a Key Role in Glucose Homeostasis

Glutaminase 2 (GLS2) is a master regulator of glutaminolysis. GLS2 converts glutamine to glutamate, thereby playing a role in cellular energy production. GLS2 is abundant in the liver, and is also found in pancreatic β-cells. However, the role of GLS2 in pancreatic islets – in which both ɑ- and β- cells are present – associated with glucose metabolism is currently unknown.

6 Jul 2023

Microalgae Grown in the Lab for Producing Biofuel

A group of researchers at the State University of Campinas (UNICAMP) in Brazil have grown microalgae under controlled conditions in a laboratory in order to use their metabolites, especially lipids, with the prime purpose of producing biofuel.

20 Apr 2023

Eye color genes play important roles in maintaining retinal health

Metabolic pathways consist of a series of biochemical reactions in cells that convert a starting component into other products.

24 Mar 2023

Identifying biomarkers that help treat fatty liver patients with a personalized diet

Recent research from the University of Jyväskylä contrasted the gut microbiota and gut-derived metabolites of healthy controls and fatty liver patients. The findings show that some microbial metabolites are linked to liver fat content.

23 Mar 2023

Influence of molecular component of caffeine on gut health

Certain microbes are considered to play a role in the development of inflammatory disorders such as inflammatory bowel disease (IBD).

16 Mar 2023

New therapeutic approaches to treat autoimmune diseases using a metabolite

Researchers have revealed the modulatory effect of the anti-inflammatory metabolite itaconate on T helper and T regulatory cells, which may lead to new therapeutic approaches to treating some autoimmune diseases.

16 Mar 2023

Experts unravel a vast network that shows how cells adjust in real-time to withstand stresses

Every minute of every day, our body adapts to meet the needs of each moment. When we binge on carbs, exercise, or become sick, chemical reactions inside our cells switch on, slow down, or shift strategy so that we have the energy and strength we need.

14 Mar 2023

Study shows link between a mitochondrial metabolite and activation of inflammatory response

A new study shows for the first time a connection between a mitochondrial metabolite and the activation of an inflammatory response.

9 Mar 2023

Researchers show how the production of different macromolecules peaks at different times

Textbooks will tell you that in dividing cells, the production of new DNA peaks during the S-phase, while production of other macromolecules, such as proteins, lipids, and polysaccharides, continues at more or less the same level.

28 Feb 2023

Study shows why a specific gene mutation has opposite effects on mice and human cancers

A small but significant metabolic difference between human and mouse lung tumor cells, has been discovered by Weill Cornell Medicine researchers, explaining a discrepancy in previous study results, and pointing toward new strategies for developing cancer treatments.

27 Feb 2023

Scientists receive $2.5 million NIH grant to define the role of lipid droplets in muscle stem cell function

A team of Purdue University scientists led by Shihuan Kuang has received a $2.5 million grant from the National Institutes of Health to define the role of lipid droplets in muscle stem cell function, a study with implications in both humans and livestock.

24 Feb 2023

New compound found in cigarette smoke damages human lung cells’ DNA

Once in a while, people are exposed to possibly detrimental substances in the environment or through their habits or diets. For instance, a compound discovered in cigarette and industrial smoke, benzo(a)pyrene (BaP), is responsible to damage DNA.

23 Feb 2023

Using fungi to transform ocean plastic waste into key pharmaceutical components

Research on fungi underway at the University of Kansas has helped transform tough-to-recycle plastic waste from the Pacific Ocean into key components for making pharmaceuticals.

18 Jan 2023

Analyzing the success rate of cell-cell metabolite exchange

It is said that when there is an exchange of metabolic products of the cells with other cells, their lifespan gets longer. This discovery has been given by a research group at Charité – Universitätsmedizin Berlin, which made the breakthrough in a study with the help of yeast cells.

11 Jan 2023

Pill-shaped ingestible biosensing system enables continuous monitoring in the intestinal environment

Engineering researchers have developed a battery-free, pill-shaped ingestible biosensing system designed to provide continuous monitoring in the intestinal environment.

6 Dec 2022

New method reveals how photosynthetic microalgae interact with their environment

Microalgae are algae too small to see with the human eye that live in both fresh and sea water. They are responsible for half of fixation of carbon that occurs on Earth through photosynthesis.

2 Nov 2022

Metabolite from pomegranate to boost immune cells that fight tumors

Researchers from the Georg-Speyer-Haus in Frankfurt am Main, Germany, and Goethe University Frankfurt have succeeded in developing a new strategy for the treatment of colorectal cancer as part of an interdisciplinary initiative of the LOEWE Center Frankfurt Cancer Institute (FCI).

28 Oct 2022

Organic chemical compounds impact the abundances, compositions of reef microorganisms differently

Stumbling upon a new source of underwater caffeine was just an added bonus of a new study examining the impact of chemical compounds that corals release into the seawater.

20 Oct 2022

Drug discovery method facilitates promising treatment approaches for metabolic diseases

The body’s chemical processes known as “metabolism” produce the raw materials needed for development and general health.

17 Oct 2022