Metabolites News and Research

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Metabolic Insights into Immune Cell Activation and Response

Researchers from Children's Hospital of Philadelphia identified a key metabolite in cells that helps direct immune responses and explains at a single cell level why immune cells that most efficiently recognize pathogens, vaccines, or diseased cells grow and divide faster than other cells.

18 Mar 2024

New Research Highlights Gut's Role in Preventing Infections

According to a study published in the journal Nature, gut bacteria and a diet high in the amino acid tryptophan can protect against pathogenic E. coli, which can cause severe upset stomach, cramps, fever, intestinal bleeding, and renal failure.

14 Mar 2024

Study Reveals Unique Bacterial Fingerprints and Their Impact on Health

The trillions of bacteria that call your body home -; collectively known as the microbiome -; appear to be unique to you, like a fingerprint.

13 Mar 2024

Blood-Based Markers Unveil Secrets of Biological Aging

University of Pittsburgh researchers have uncovered blood-based markers linked with healthy and rapid aging, allowing them to predict a person's biological age -; how fast a person's cells and organs age regardless of their birthdate.

11 Mar 2024

Unlocking the Potential of Fonio Seed Microbiome Engineering for Climate-Resilient Crops

Fonio (Digitaria exilis), a type of millet, is the oldest indigenous crop in West Africa and one of the fastest maturing cereals.

1 Mar 2024

Gut Microbial Metabolite Linked to Increased Thrombosis Risk in COVID-19 Patients

A gut microbial metabolite called 2-methylbutyrylcarnitine (2MBC) plays a role in exacerbating thrombosis -- the formation of blood clots – researchers report February 23rd in the journal Cell Metabolism.

26 Feb 2024

The Surprising Link Between Tea Quality and Root Bacteria

The type of tea used to make a fine cup of tea will significantly impact its flavor. However, a study published in the journal Current Biology reveals that the collection of bacteria found on tea roots is another essential component needed to make a great cup of tea.

16 Feb 2024

Exploring the Potential of Gut-Derived Nisin-Like Lantibiotics

A common preservative used to kill pathogens in food has been found to also affect beneficial bacteria, endangering the balance of beneficial bacteria in the gut microbiome.

5 Feb 2024

Study Unveils Dual Role of 7-DHC in Ferroptosis and Cancer Cell Survival

Cell death is fundamental to life and, thus, healthy aging. In the realm of cellular biology, ferroptosis (a form of programmed cell death) has emerged not only as a focal point of research for its potential in eliminating cancer cells, but also its role in a plethora of other diseases, including neurodegenerative diseases such as Alzheimer's disease, eye diseases such as Retinitis pigmentosa and age-related macular degeneration, as well as ischemia, cardiovascular disease, liver disease, acute kidney injury and inflammation.

2 Feb 2024

Algal Blooms May Pose More Health Risks Than Previously Thought

Florida's 156-mile-long Indian River Lagoon (IRL) borders five different counties and has five inlets that connect the lagoon with the Atlantic Ocean.

16 Jan 2024

Honeybees Directly Provide Nutrients to Gut Bacteria

Bacteria have adapted to all terrestrial environments. Some have evolved to survive in the gut of animals, where they play an important role for their host; they provide energy by degrading indigestible food, they train and regulate the immune system, they protect against invasion by pathogenic bacteria, and they synthesize neuroactive molecules that regulate the behavior and cognition of their host.

16 Jan 2024

Boosting Post-Transplant Survival: Tailoring Gut Microbiome to Fight GvHD

After stem cell transplantation, the donated immune cells sometimes attack the patients' bodies. This is known as graft versus host disease or GvHD.

9 Jan 2024

Unlocking the Gut's Metabolic Secrets

The variety of enzymes that microbes employ to make energy in the low-oxygen environment of the gut is highlighted by a survey of bacterial genomes.

8 Jan 2024

B12-Producing Gut Bacteria Modulate Neurotransmitter Levels and Reduce Seizures in C. elegans

A new study published in Nature Cell Biology by Mark Alkema, PhD, professor of neurobiology, establishes an important molecular link between specific B12-producing bacteria in the gut of the roundworm C. elegans and the production of acetylcholine, a neurotransmitter important to memory and cognitive function.

5 Jan 2024

Breakthrough in Synthetic Biology: Researchers Build Artificial CO2-Fixing Pathway

Synthetic biology offers the opportunity to build biochemical pathways for the capture and conversion of carbon dioxide (CO2).

3 Jan 2024

New Insights Into the Microbiome's Influence on Kidney Stone Risk

A new study from Lawson Health Research Institute and Western University published in the journal Microbiome has found changes in the microbiome in multiple locations in the body are linked to the formation of kidney stones.

21 Dec 2023

Exploring Plants’ Complex Metabolic Networks

Plants have developed intricately complex metabolic networks. Over the years, researchers have concentrated on unraveling the processes through which plants generate secondary metabolites—compounds produced to bolster their defense and survival mechanisms.

19 Dec 2023

SERS Decodes Cancer's Whispers: Metabolites Reveal Tumor Communication and Potential Targets

A study conducted by pre-PhD researcher Pablo S. Valera and recently published in PNAS demonstrates the potential of surface-enhanced Raman spectroscopy (SERS) to explore metabolites secreted by cancer cells in cancer research.

19 Dec 2023

Breakthrough Research in Leishmaniasis Reveals Pain-Suppression Pathways

For the first time, scientists have begun to figure out why the disfiguring skin lesions caused by cutaneous leishmaniasis don't hurt.

1 Dec 2023

A Novel Technique for Ribonucleotide Quantification

Scientists at the Folkhälsan Research Center have devised a novel technique enabling the straightforward quantification of ribonucleotides in small tissue and cell samples within a standard laboratory setting, without the need for specialized equipment.

28 Nov 2023