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Gaining insights into human disease biology through CRISPR platforms

In this interview, we speak with Laralynne Przybyla about how she is utilizing CRISPR platforms to understand human disease biology in greater detail.

From Society for Laboratory Automation and Screening (SLAS) 7 Feb 2023

Experimental optimization of prime editing to achieve high efficiency

Genome editing technologies have enormous potential for treating genetic diseases. Techniques like the extensively used CRISPR/Cas9 gene scissors target the source of the disease directly in the DNA.

3 Feb 2023

Deletion of p16Ink4a cells does not negatively impact β-cell mass and proliferation in mice

A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 2, entitled, "Clearance of p16Ink4a-positive cells in a mouse transgenic model does not change β-cell mass and has limited effects on their proliferative capacity."

1 Feb 2023

Key immune alarm protein that regulates inflammation identified

Trinity researchers have made a significant advance in understanding how inflammation is controlled. They recently discovered that a crucial immunological alarm protein that was previously thought to quiet the immune response apparently performs the opposite.

20 Dec 2022

Analyzing progenitor fate and dynamics long after embryonic development

According to Johns Hopkins Medicine researchers, they have devised a computer model called quantitative fate mapping that looks back in time to track the origin of cells in a fully grown organism.

14 Dec 2022

Investigating new ways to grow food in space

Growing food in space is fraught with daunting challenges, including extreme environmental stressors like radiation and microgravity.

2 Dec 2022

Gene editing technique makes new kinds of research possible in animal models

Working in teeny tiny worms, scientists can now test the effects of thousands of genetic mutations in one fell swoop.

3 Nov 2022

Novel technique expedites research into the genetics of aging

A novel technique for identifying the genes that are important for aging has been discovered by scientists at North Carolina State University.

3 Nov 2022

Conserved vacuolar sorting hub regulates autophagic flux in plants

A “hub and spoke” system allows plant cells to effectively coordinate cellular trafficking, especially for cellular recycling, also known as autophagy. Autophagosomes are specialized vesicles that capture hazardous molecules and transport them to the vacuole, where they are destroyed.

21 Oct 2022

Coral genome reveals cysteine biosynthesis pathways

Model animals, such as mice and fruit flies, have provided scientists with powerful insights into how cellular biology works. However, model animals are really just a guide, and it can be risky to generalize findings across animals from studying a selection of model organisms.

26 Sep 2022

Researchers modify the root structure of plants with synthetic genes

Crops need to be more adaptable than ever as extreme weather events like floods, droughts, and heat waves grow more frequently.

15 Aug 2022

Scientists demonstrate a new function of an enzyme that connects to age-related diseases

Aging and age-related diseases present a complex challenge to biomedical researchers.

20 Jul 2022

Rochester biologists show a selfish “supergene” using population genomics

There are several “selfish genetic elements” in the human genome that do not appear to benefit their hosts but instead appear to exist only to reproduce themselves.

8 Jul 2022

Study reveals how amphioxus model analyze the genesis and vertebrates evolution

The two rounds of whole-genome duplication that occurred throughout the evolution of vertebrates were followed by functional divergence in terms of regulatory circuits as well as gene expression patterns.

27 Jun 2022

Scientists identify factors that regulate the development of brain cells in a specific order

Researchers have identified the complete series of 10 factors that regulate the development of brain cell types in the visual system of fruit flies-; including in what order these neurons develop.

From New York University (NYU) 7 Apr 2022

ISU researchers receive major funding to go forward on blood stem cells research

For years, scientists have been unable to create a patient’s blood cells to cure blood illnesses, but a recently implemented federal funding might help IOWA State University researchers take important steps toward making that prospect a reality.

21 Mar 2022

Biosynthesis of cannabinoid precursor and other polyketides from amoebae

A research team at the Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute in Jena, Germany has developed a new method to produce complex natural products in amoebae.

7 Mar 2022

Producing New Antibiotics Through Gene Editing

In this interview, we speak to Professor Jason Micklefield about his latest research that may be able to produce new antibiotics through gene-editing technologies.

From The University of Manchester 24 Jan 2022

Green tea catechins extend the lifespan of C. elegans

Aging-US published "Green tea catechins EGCG and ECG enhance the fitness and lifespan of Caenorhabditis elegans by complex I inhibition" which reported that green tea catechins are associated with a delay in aging.

15 Nov 2021

New smart microscope developed for the imaging of biological surfaces

Modern biology relies on our ability to observe living cells using microscopes. The latest advances in optical microscopy allow cellular and sub-cellular imaging within model organisms such as the vinegar fly, zebrafish or mouse.

13 Oct 2021