therapeutics News and Research

RSS

Scientists provide a complete phenotypic landscape of SCN2A-related disorders

Researchers from Children's Hospital of Philadelphia (CHOP) affiliated with the CHOP Epilepsy Neurogenetics Initiative (ENGIN) have compiled a complete genetic and clinical analysis of more than 400 individuals with SCN2A-related disorder, which has been linked to a variety of neurodevelopmental disorders, including epilepsy and autism.

18 Mar 2021

Genetic flaw shows promise for treating eye disease

A genetic flaw may hold the key to delay or prevent the onset of a serious eye disorder that can result in blindness and vision loss.

From Walter and Eliza Hall Institute of Medical Research (WEHI) 17 Mar 2021

ADAR1 protein offers a potential therapeutic target for cancer

A research team has discovered a new role of ADAR1 and found that the ADAR1p110 isoform controls genome stability at the ends of chromosomes.

15 Mar 2021

Study on AEG12 mosquito protein could lead to therapeutics against deadly viruses

Researchers have found that AEG12, a mosquito protein, strongly suppresses the class of viruses causing dengue, yellow fever, Zika, and West Nile.

11 Mar 2021

Promising drug targets identified for aggressive forms of cancers

Scientists have largely been producing transcriptomic data in an attempt to find clues about modified cellular pathways that may be fueling cancer behavior.

5 Mar 2021

Engineered safety switch reduces CAR-T immunotherapy-related side effects

UNC Lineberger Comprehensive Cancer Center researchers have successfully used an experimental safety switch, incorporated as part of a chimeric antigen receptor T-cell (CAR-T) therapy, a type of immunotherapy, to reduce the severity of treatment side effects that sometimes occur.

5 Mar 2021

New technique reveals the tricks that cancer cells use to avoid immunotherapies

By harnessing the immune system against cancer, immunotherapies have revolutionized the way some types of cancer are treated. But most patients--across cancer types--do not respond, and in most cases, scientists are at a loss as to why.

2 Mar 2021

Study reveals new therapeutic targets on SARS-CoV-2 Spike protein

Considering the recent COVID-19 pandemic, significant investigations are being made to find out how the SARS-CoV-2 Spike protein binds to a human cell.

From Penn State University 23 Feb 2021

Electron cryo-microscopy sheds light on how bioenergy makers are made in our body

Mitochondria are organelles that act as the powerhouses in our body. They use oxygen which we inhale and the food we eat to produce energy that supports our life.

22 Feb 2021

Cryogenic electron microscopy reveals shape of glutamate transporters involved in neurological diseases

An international research team has uncovered the shape of the glutamate transporter and helps explain how the human brain cells interact with each other.

18 Feb 2021

Study suggests a way to improve immunotherapy by altering immune cells’ access to sugar

Cancer cells and immune cells share something in common: They both love sugar. Sugar is an important nutrient. All cells use sugar as a vital source of energy and building blocks. For immune cells, gobbling up sugar is a good thing, since it means getting enough nutrients to grow and divide for stronger immune responses. But cancer cells use sugar for more nefarious ends.

17 Feb 2021

New understanding of tumor microenvironment could help enhance immunotherapy

A paper published today in Nature shows how chemicals in the areas surrounding tumors--known as the tumor microenvironment--subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy.

From University of Pittsburgh 16 Feb 2021

Electrochemical sensor for rapid detection of multiple sepsis biomarkers in whole blood

Many life-threatening medical conditions, such as sepsis, which is triggered by blood-borne pathogens, cannot be detected accurately and quickly enough to initiate the right course of treatment.

15 Feb 2021

New AI-based method produces new diversity of AAV capsids for optimized gene therapy

Dyno Therapeutics has demonstrated the use of AI to created an unparalleled range of adeno-associated virus capsids that can evade the immune system.

15 Feb 2021

Study may lead to alternative treatment for potentially addictive opioid pain killers

When two naturally occurring lipids are altered using a process called epoxidation, they are transformed into powerful agents that target numerous cannabinoid receptors in neurons, disrupting pathways that promote inflammation and pain.

11 Feb 2021

New way to quantify the key characteristics of RNA-binding proteins

A research team from Case Western Reserve University has discovered a new way to quantify the main characteristics of proteins that bind to RNA in cells—a finding that may enhance one’s interpretation of how gene regulation is disrupted in infections, neurodegenerative diseases, or cancer.

11 Feb 2021

An outlook on latest trends in peptide drug discovery and development

Currently, there are more than 80 peptide drugs on the global market and about twice as many in clinical development. Due to their beneficial properties, these biomolecules play already an important role in the treatment of diseases such as diabetes, cancer, hormone disorders, HIV infection, and multiple sclerosis.

11 Feb 2021

Seasonal human coronavirus antibodies not associated with protection against SARS-CoV-2

Past exposure to seasonal coronaviruses (CoVs), which cause the common cold, does not result in the production of antibodies that protect against the novel coronavirus SARS-CoV-2, according to a study led by Scott Hensley, PhD, an associate professor of Microbiology at the Perelman School of Medicine at the University of Pennsylvania.

11 Feb 2021

Scientists implicate disruption in prenatal neurogenesis in the development of autism

A new study of autism risk genes by UC San Francisco and UC Berkeley scientists implicates disruption in prenatal neurogenesis - a process in which specialized "progenitor" cells give rise to new brain cells - in the development of autism spectrum disorders (ASDs).

9 Feb 2021

Researchers propose new technique to detect SARS-CoV-2

SARS-CoV-2 infects human beings by attaching its surface-exposed spike proteins to ACE2 receptors, which in turn, are exposed on the cell membranes.

5 Feb 2021

therapeutics News and Research

Scientists provide a complete phenotypic landscape of SCN2A-related disorders

Genetic flaw shows promise for treating eye disease

ADAR1 protein offers a potential therapeutic target for cancer

Study on AEG12 mosquito protein could lead to therapeutics against deadly viruses

Promising drug targets identified for aggressive forms of cancers

Engineered safety switch reduces CAR-T immunotherapy-related side effects

New technique reveals the tricks that cancer cells use to avoid immunotherapies

Study reveals new therapeutic targets on SARS-CoV-2 Spike protein

Electron cryo-microscopy sheds light on how bioenergy makers are made in our body

Cryogenic electron microscopy reveals shape of glutamate transporters involved in neurological diseases

Study suggests a way to improve immunotherapy by altering immune cells’ access to sugar

New understanding of tumor microenvironment could help enhance immunotherapy

Electrochemical sensor for rapid detection of multiple sepsis biomarkers in whole blood

New AI-based method produces new diversity of AAV capsids for optimized gene therapy

Study may lead to alternative treatment for potentially addictive opioid pain killers

New way to quantify the key characteristics of RNA-binding proteins

An outlook on latest trends in peptide drug discovery and development

Seasonal human coronavirus antibodies not associated with protection against SARS-CoV-2

Scientists implicate disruption in prenatal neurogenesis in the development of autism

Researchers propose new technique to detect SARS-CoV-2

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

Latest in Genomics