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Ancestry Bias can Cause CRISPR Screens to Miss Cancer Dependencies

CRISPR/Cas9 gene editing has made possible a multitude of biomedical experiments including studies that systematically turn off genes in cancer cells to look for ones that the cancer cells heavily depend on to survive and grow.

17 Jun 2024

Bacterial Buckling: Filamentous Cyanobacteria Bend Under Pressure

Filamentous cyanobacteria buckle at a certain length when they encounter an obstacle. This was discovered by the research group of Stefan Karpitschka, group leader at the Max Planck Institute for Dynamics and Self-Organization and professor at the University of Konstanz.

17 Jun 2024

St. Jude Researchers Discover NLRC5's Role in Inflammatory Cell Death

The innate immune system is responsible for protecting the human body from threats that could cause disease or infection.

17 Jun 2024

TIMP-1 Protein Enhances Immune Defense Against Cancer

Researchers at the University of Turku in Finland have found a new function for an existing protein.

17 Jun 2024

Scientists Achieve Autonomous Control of Microscopic Machines

Tohoku and Kyoto University researchers have successfully created a DNA-based molecular controller that controls molecular robot building and disassembly autonomously.

17 Jun 2024

New Clinical Trial Offers Path to Sickle Cell Cure

The most recent results from a clinical trial were given by researchers in an effort to find a cure for sickle cell disease, a painful genetic blood illness that has few available treatments.

17 Jun 2024

Stem cell-based kidney chip revolutionizes disease modeling and research

An organ-on-chip system containing a kidney glomerulus using human-induced pluripotent stem cells and an ultrathin membrane.

17 Jun 2024

Gene Editing Yields New Insights into Tardigrade Resilience

Some species of tardigrades are highly and unusually resilient to various extreme conditions fatal to most other forms of life.

14 Jun 2024

MIT Researchers Develop Amber-Like Polymer for Room-Temperature DNA Storage

In the movie "Jurassic Park," scientists extracted DNA that had been preserved in amber for millions of years, and used it to create a population of long-extinct dinosaurs.

14 Jun 2024

Johns Hopkins Scientists Engineer Synthetic Cells to Mimic Symmetry Breaking

In a feat aimed at understanding how cells move and creating new ways to shuttle drugs through the body, scientists at Johns Hopkins Medicine say they have built a minimal synthetic cell that follows an external chemical cue and demonstrates a governing principle of biology called "symmetry breaking."

14 Jun 2024

Exploring the Potential of Bacteriophages

Bacteriophages, viruses that target and destroy bacteria, are ubiquitous in the natural world. They play a crucial role in controlling microbe populations, though the mechanisms behind this regulation are not yet fully understood.

14 Jun 2024

First Evidence of Oocyte Cohesion Rejuvenation Discovered in Fruit Flies

A Dartmouth study conducted on fruit flies reports the first evidence in any organism that oocytes-;the cells that become eggs-;regularly rejuvenate the critical protein linkages that bind chromosomes together.

13 Jun 2024

Germ Cells Found to Drive Sex-Dependent Lifespan Differences in Vertebrates

Women live longer than men. This isn't unique to humans, either; we see this trend in a wide range of other animals. Biologists have theorized that the discrepancy in life expectancy between sexes might be partly related to reproduction, but how?

13 Jun 2024

Study Uncovers Link Between Genetic Variants and Mosaic Loss of X Chromosome in Aging Women

Researchers have identified inherited genetic variants that may predict the loss of one copy of a woman's two X chromosomes as she ages, a phenomenon known as mosaic loss of chromosome X, or mLOX.

13 Jun 2024

Progress in Ingestible Microbiome Sampling Pill Technology

At the Tufts University School of Engineering, significant progress has been made in creating a tiny device that is comparable in size to a vitamin pill and can be swallowed to sample the entire population of microorganisms in a person's gastrointestinal tract.

13 Jun 2024