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Location is the key for psychedelic drugs to work

Location, location, location is the key for psychedelic drugs that could treat mental illness by rapidly rebuilding connections between nerve cells.

17 Feb 2023

New method for studying mitochondria using advanced imaging technology

Scientists at Scripps Research have developed an advanced imaging-based approach that provides a unique perspective on mitochondria, which are best known as the “powerhouses” of cells.

17 Feb 2023

New approach to better target cellular proteins

By studying how enzymes move from one membrane compartment to another inside a cell, scientists at the University of Illinois Chicago have figured out a way to better target cellular proteins, which play a role in many diseases.

16 Feb 2023

The essential protein needed for immune evasion and tumor cell metabolism

Typically, tumor cells change their energy metabolism and take in more glucose to enable their rapid division and spread. As a result, the body’s immune response to cancer is suppressed by limiting the immune cells’ access to glucose.

15 Feb 2023

How the immune response in the brain aggravates epilepsy

Biologists at the University of Iowa have conclusively connected epilepsy with the brain’s immune system.

15 Feb 2023

New method triggers and analyzes the dynamics of brain protein linked to Alzheimer’s

Scientists are not yet clear on how the tau protein changes from a benign protein essential for normal function in our brains into the toxic neurofibrillary tangles that are a signature of Alzheimer's and other neurodegenerative diseases.

15 Feb 2023

Versatile molecular toolbox expands the scope of gene regulation

Rice University scientists have enlisted widely used cancer therapy systems to control gene expression in mammalian cells, a feat of synthetic biology that could change how diseases are treated.

15 Feb 2023

New ways to diagnose learning and memory disorders

By showing Welles's movie "Touch of Evil" to mice, Chinmay Purandare, PhD, and Prof. Mayank Mehta of UCLA have uncovered surprising and important new insights about how neurons form memories. The discovery points to new ways to diagnose Alzheimer's and other learning and memory impairments, while also improving artificial intelligence.

15 Feb 2023

Study charts seasonal and circadian genetic variation across the human body

The daily rotation of Earth and its yearly voyage around the Sun marks the natural rhythm of life on the planet.

14 Feb 2023

Study explains why cancers stop responding to kinase inhibitors and come back stronger

More than 70 FDA-approved cancer drugs are kinase inhibitors, which work by blocking kinases-;enzymes that add phosphate groups to molecules in the cell-;and preventing the chemical activity necessary for signaling and growth in cancer cells.

14 Feb 2023

Study reveals the mechanisms that prevent effective cancer cell death

Cancer is a disease driven by gene mutations. These mutated genes in cancer fall into two major categories: tumor suppressors and oncogenes. Mutations in tumor suppressor genes can allow tumors to grow unchecked – a case of no brakes – while mutations in oncogenes can activate cell proliferation, pushing the gas pedal all the way to the floor.

14 Feb 2023

Robust new method accurately identifies eight antidepressants

In recent years, a mass spectrometry process that can detect the amounts of drugs in a biological sample, such as blood, has become a powerful diagnostic tool for helping medical professionals identify and monitor levels of therapeutic drugs in patients, which can cause unwanted or dangerous side effects.

14 Feb 2023

Extracts from two common wild plants block SARS-CoV-2 from entering human cells

Two common wild plants contain extracts that inhibit the ability of the virus that causes COVID-19 to infect living cells, an Emory University study finds.

13 Feb 2023

A treatment strategy to hasten cancer cell death

Gene mutations are the cause of cancer. Tumor suppressors and oncogenes are the two main groups of these altered genes in cancer. Mutations in oncogenes can drive cell proliferation, pushing the gas pedal to the floor, whereas mutations in tumor suppressor genes can cause tumors to grow unchecked—a situation in which there is no control.

13 Feb 2023

Identifying the molecular switch that regulates autophagy in plants

Autophagy, commonly known as “self-eating,” is a cellular quality control mechanism that relieves the cell of protein aggregates and damaged organelles. This system is inert under ordinary conditions and is only activated in the presence of persistent cellular stress.

13 Feb 2023

Research reveals gene expression changes in two brain regions of individuals with cocaine use disorder

Individuals with cocaine use disorder exhibit gene expression changes in two brain regions: the nucleus accumbens, a region associated with reward, and the caudate nucleus, a region mediating habit formation, according to research conducted at the Icahn School of Medicine at Mount Sinai and published February 10 in Science Advances.

13 Feb 2023