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Scientists Discover Dual Challenges in DNA Replication Process

Half a century ago, scientists Jim Watson and Alexey Olovnikov independently realized that there was a problem with how our DNA gets copied.

29 Feb 2024

Discovery of a Subset of Human Short Introns That Are Spliced Out by a Novel Mechanism

The well-known essential pre-mRNA splicing factor U2AF heterodimer (U2AF2–U2AF1) has been considered to mediate early splicing reaction in all introns of different lengths.

15 Feb 2024

Identifying Phosphorylation Sites in Legume-Rhizobia Symbiosis

Legume plants are unique in that they can interact with rhizobia, which are soil-dwelling bacteria that fix nitrogen.

13 Feb 2024

Safer and More Effective Cell Therapy for Spinal Cord Injuries

For patients with spinal cord injuries, a small gadget developed by researchers at MIT and the Singapore-MIT Alliance for Research and Technology may help to increase the efficacy and safety of cell therapy treatments.

8 Feb 2024

How the Brain Controls its Cravings for Water and Salt

For terrestrial creatures, including humans, to survive, they must drink plenty of water and eat enough salt. Neural pathways comprising many brain regions intriguingly control both thirst and salt appetite.

29 Jan 2024

Boosting Central Memory T Cells with Targeted Protein Modulation

The Hackensack Meridian Center for Discovery and Innovation's (CDI) Xue Lab has made yet another advancement in the understanding of the immune system and its potential for disease-fighting modulation.

22 Jan 2024

Breakthrough 3D Vascular Sheet Mimics Atherosclerosis for High-Throughput Drug Screening

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials.

16 Jan 2024

Novel Amino Acid Nanoparticles Offer Hope for Fighting Multi-Drug Resistant Cancers

Amino acids, such as tyrosine and tryptophan, are the fundamental building blocks that make up proteins.

9 Jan 2024

Breakthrough in Synthetic Biology: Researchers Build Artificial CO2-Fixing Pathway

Synthetic biology offers the opportunity to build biochemical pathways for the capture and conversion of carbon dioxide (CO2).

3 Jan 2024

Mettl3 Drives Powerful Immune Defense of CD8 T Cells

This study is led by Dr. Shuyang Yu (College of Biological Sciences, China Agricultural University), Dr. Jingyu Xu (The Collaborative Innovation Center of Tissue Damage Repair and Regeneration Medicine of Zunyi Medical University) and Dr. Xuguang Du (College of Biological Sciences, China Agricultural University) and illustrated the key role of Mettl3 in CD8 T cell response during acute infection model.

2 Jan 2024

AI-Powered Drug Breakthrough: Insilico Unveils Potent FGFR2/3 Inhibitor for Solid Tumors

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

29 Dec 2023

Xeno-Free Monkey PSC Culture System Enables Deriving, Tracking, and Differentiating Stem Cells

Non-human primates (NHPs) have a high degree of similarity to humans compared to other animal models.

26 Dec 2023

Novel Technique for High-Resolution Spectral Analysis of the Eye Fundus

Many ocular diseases involve changes in the structure and function of different regions of the back of the eye, also known as the "eye fundus."

18 Dec 2023

Presage Biosciences and AstraZeneca Partner to Advance Immuno-Oncology Research for Head and Neck Cancer

Presage Biosciences, a pioneering translational oncology company whose mission is to use CIVO and spatial molecular profiling to understand the complexity of drug response in the tumor microenvironment (TME), has entered into an agreement with AstraZeneca, a global biopharmaceutical company.

1 Dec 2023

in vivo News and Research

Scientists Discover Dual Challenges in DNA Replication Process

Discovery of a Subset of Human Short Introns That Are Spliced Out by a Novel Mechanism

Identifying Phosphorylation Sites in Legume-Rhizobia Symbiosis

Safer and More Effective Cell Therapy for Spinal Cord Injuries

How the Brain Controls its Cravings for Water and Salt

Boosting Central Memory T Cells with Targeted Protein Modulation

Breakthrough 3D Vascular Sheet Mimics Atherosclerosis for High-Throughput Drug Screening

Novel Amino Acid Nanoparticles Offer Hope for Fighting Multi-Drug Resistant Cancers

Breakthrough in Synthetic Biology: Researchers Build Artificial CO2-Fixing Pathway

Mettl3 Drives Powerful Immune Defense of CD8 T Cells

AI-Powered Drug Breakthrough: Insilico Unveils Potent FGFR2/3 Inhibitor for Solid Tumors

Xeno-Free Monkey PSC Culture System Enables Deriving, Tracking, and Differentiating Stem Cells

Novel Technique for High-Resolution Spectral Analysis of the Eye Fundus

Presage Biosciences and AstraZeneca Partner to Advance Immuno-Oncology Research for Head and Neck Cancer

New Irreversible Inhibitor Overcomes Drug Resistance in Cancer Cells

Novel Biosensors Uncover Brain Activity

Exploring the Probiotic Potential of Fungi in Food Production

Pusan National University Scientists Explore OsMATL2 Gene as a Candidate for Haploid Induction in Rice

The Intriguing Phenomenon of Cellular Reprogramming

Study Reports High-Resolution Structures of CAF-1

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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