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Mapping Neurodevelopmental Disease with High-Throughput In Vivo Perturb-seq

The brain is often referred to as a "black box"-;one that's difficult to peer inside and determine what's happening at any given moment.

21 May 2024

Unraveling Gardnerella Diversity in the Vaginal Microbiome

Researchers from North Carolina State University have found that multiple species of Gardnerella, bacteria sometimes associated with bacterial vaginosis (BV) and pre-term birth, can coexist in the same vaginal microbiome.

21 May 2024

Sonification Reveals Hidden Patterns in Protein Folding Dynamics

By converting their data into sounds, scientists discovered how hydrogen bonds contribute to the lightning-fast gyrations that transform a string of amino acids into a functional, folded protein.

21 May 2024

Mesenchymal stem cell-derived exosomes carrying vincristine sulfate are effective in killing cancer stem cells

Whether loading vincristine sulfate into mesenchymal stem cell-derived exosomes could improve the targeted delivery of the drug specifically to cancer stem cells.

21 May 2024

Molecular Machinery Behind Plant Growth and Oil Production Deciphered

Proteins are molecular machines, with flexible pieces and moving parts. Understanding how these parts move helps scientists unravel the function a protein plays in living things -; and potentially how to change its effects.

20 May 2024

Brookhaven Scientists Unravel Evolutionary Origins of Plant Lignin

Scientists from the U.S. Department of Energy's (DOE) Brookhaven National Laboratory have discovered that a protein responsible for the synthesis of a key plant material evolved much earlier than suspected.

20 May 2024

Study Identifies Ruminococcus gnavus as Key Microbial Partner in Cancer Immunotherapy

Roughly one in five cancer patients benefits from immunotherapy – a treatment that harnesses the immune system to fight cancer.

20 May 2024

Study Reveals How Sweet Taste Receptor Regulates Blood Sugar and Insulin

The rich research portfolio of the Monell Chemical Senses Center on sweet taste goes way back: Monell scientists were one of four teams in 2001 that found and described the mammalian sweet taste receptor – TAS1R2-TAS1R3.

20 May 2024

Viruses Offer Efficient Delivery for Precise Plant Breeding

The application of genome editing in plant molecular breeding is hampered by the lack of straightforward and efficient methods for introducing genome editing reagents into plants, despite the technology's great potential.

20 May 2024

Phages and Zombie Cells Regulate Abundant Marine Bacteria

The movement of matter and energy required for ocean life is regulated by marine microbes, of these, approximately one-third are members of the bacterial group SAR11.

20 May 2024

Unveiling the Anti-Inflammatory and Anti-Obesity Potential of Menthol-Derived Esters

Obesity and inflammatory diseases are increasing in prevalence and contribute to the growing burden of lifestyle disorders such as diabetes and hypertension. There is a lack of naturally derived alternatives to tackle these issues

20 May 2024

Takara Bio Launches PrimeCap T7 RNA Polymerase for mRNA Therapy Development

Takara Bio announces the launch of PrimeCap™ T7 RNA Polymerase (low dsRNA), a mutant T7 RNA polymerase suitable for mRNA therapeutic research and development.

20 May 2024

Study Reveals How tRNA Modification Influences Malaria Drug Resistance

Researchers from the Antimicrobial Resistance (AMR) Interdisciplinary Research Group (IRG) at Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, in collaboration with Massachusetts Institute of Technology (MIT), Columbia University Irving Medical Center (CUIMC), and Nanyang Technological University, Singapore (NTU Singapore), have discovered a link between malaria parasites’ ability to develop resistance to antimalarial drugs – specifically artemisinin (ART) – through a cellular process called transfer Ribonucleic acid (tRNA) modification.

20 May 2024

Breakthrough in Natural Vanillin Production Using Engineered Enzyme

Vanilla extract is one of the most widely used flavoring compounds in food products and cosmetics.

17 May 2024

Discovery of New Cancer Cell Death Pathway Involving Schlafen11 Gene

Chemotherapy kills cancer cells. But the way these cells die appears to be different than previously understood.

17 May 2024

Sex-Specific Effects of Germline Regulation on Longevity and Repair in Vertebrates

The study revealed unexpected and sex-specific effects of germline regulation on longevity and somatic repair in vertebrates.

17 May 2024

Study: South African Leopards Exhibit Exceptional Genetic Diversity

Researchers say the discovery of very high genetic diversity in leopards found in the Highveld region of South Africa has increased the need for conservation efforts to protect leopards in the country.

16 May 2024

H5N1 Strain Shows Limited Airborne Transmission in Ferrets

The highly virulent H5N1 avian influenza was initially found in dairy cattle in the United States in March, and by May, outbreaks had been reported from nine states. The research was published in the journal Nature Communications.

16 May 2024

Herpes Gene Therapy Achieves 90% Viral Reduction in Pre-Clinical Studies

Researchers at Fred Hutch Cancer Center have found in pre-clinical studies that an experimental gene therapy for genital and oral herpes removed 90% or more of the infection and suppressed how much virus can be released from an infected individual, which suggests that the therapy would also reduce the spread of the virus.

16 May 2024

Repetitive Tasks Crystallize Memory Pathways in the Brain

According to a recent study conducted by UCLA Health, repeated practice not only helps to improve skills but also causes significant alterations in the memory pathways in the brain.

16 May 2024