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Embryonic Cells Pressed into Organizers: Mechanism Unveiled

A collaboration between research groups at the University of California, TU Dresden in Germany and Cedars-Sinai Guerin Children's in Los Angeles has identified a mechanism by which embryonic cells organize themselves to send signals to surrounding cells, telling them where to go and what to do.

4 Apr 2024

High-Resolution Map Tracks Cellular Changes During Inflammation

Cells within the intestines fulfill diverse functions, including nutrient absorption, sensing, and regulating homeostasis. Gut inflammation is a characteristic that sets certain chronic disorders apart.

3 Apr 2024

Researchers Advocate for “Pathogen Prospecting” to Fight Malaria

A team of scientists is urging colleagues worldwide to participate in what they refer to as “pathogen prospecting,” which involves locating archival mosquito specimens in collections and museums and examining them for pathogens that could have transmitted malaria to humans while feeding on their blood.

2 Apr 2024

Rare YKT6 Gene Variants Linked to New Neurological Disorder

A recent collaborative study has discovered rare variants in the YKT6 gene as the cause of a new neurological disorder characterized by developmental delays along with severe progressive liver disease and a potential risk for liver cancer.

2 Apr 2024

Acidic Fortress of Tumors Could Rebuff Immune Cells

Cancer cells release a significantly more concentrated level of acid than previously known, forming an "acid wall" that could deter immune cells from attacking tumors, UT Southwestern Medical Center scientists show in a new study.

2 Apr 2024

Study may Provide a Roadmap for Addressing Cytokine Storms in Severe COVID-19

A recent USC study provides new information about why SARS-CoV-2, the virus behind the COVID-19 pandemic, may elicit mild symptoms at first but then, for a subset of patients, turn potentially fatal a week or so after infection.

1 Apr 2024

Genetic Origins of Birth Defects Discovered

A new study led by the University of California, Irvine has revealed a potential shift in our basic knowledge of the origins of birth defects, which affect about 3 percent of babies born in the United States each year.

29 Mar 2024

Canadian-Led Study Identifies Genetic Links to Cerebral Palsy

A Canadian-led study has identified genes which may be partially responsible for the development of cerebral palsy.

29 Mar 2024

Research Sheds Light on Blood Cell Production in Mouse Skeleton

Imagine being able to count the different types of blood cells being formed inside the tiny bones of a mouse and pinpointing the strings and clusters of cells within the bone marrow that are responsible for producing specific types of blood cells.

25 Mar 2024

Baby Gut Bacteria Found to Play Crucial Role in Immune Development

Researchers at Weill Cornell Medicine have shown that certain bacteria invade the stomach soon after birth and produce serotonin, a neurotransmitter that helps teach gut immune cells.

18 Mar 2024

Machine Learning Accelerates Personalized T Cell Therapy Development for Cancer Patients

Making a personalized T cell therapy for cancer patients currently takes at least six months; scientists at the German Cancer Research Center and the University Medical Center Mannheim have shown that the laborious first step of identifying tumor-reactive T cell receptors for patients can be replaced with a machine learning classifier that halves this time.

18 Mar 2024

Metabolic Insights into Immune Cell Activation and Response

Researchers from Children's Hospital of Philadelphia identified a key metabolite in cells that helps direct immune responses and explains at a single cell level why immune cells that most efficiently recognize pathogens, vaccines, or diseased cells grow and divide faster than other cells.

18 Mar 2024

Transcriptome Profiling Reveals Age-Associated Changes in the Human Brain

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 5, entitled, "Genome-wide transcriptome profiling and development of age prediction models in the human brain."

18 Mar 2024

Exploring the Link Between Gut Health and Effective Milk Allergy Treatment

Exploring the Link Between Gut Health and Effective Milk Allergy Treatment At the RIKEN Center for Integrative Medical Sciences in Japan, researchers under the direction of Hiroshi Ohno have found a connection between gut microbiota and the effectiveness of oral immunotherapy for milk allergies.

15 Mar 2024

DNA Origami Revolutionizes Cancer Immunotherapy: The DoriVac Breakthrough

Therapeutic cancer vaccines are a form of immunotherapy in the making that could not only destroy cancer cells in patients, but keep a cancer from coming back and spreading.

15 Mar 2024

Scientists Detect Higher Bacterial Counts in Single-Serving Milks

Cornell University scientists have detected higher bacterial counts in commercial, paperboard single-serving containers two weeks after processing than milk packaged in larger containers from the same facilities.

12 Mar 2024

Researchers Unveil a Key Gene with a Central Role in Learning and Memory Across Mammalian Brain Cells

Discoveries in mice could guide the quest for treatments aimed at addressing brain developmental disorders in children with SYNGAP1 gene mutations.

1 Mar 2024

Tandem Repeat Expansions Linked to Cardiomyopathy Risk, Reveals Study

In the first study to use whole genome sequencing to examine tandem repeat expansions in heart conditions, scientists at The Hospital for Sick Children (SickKids) have laid the groundwork for early detection of and future precision therapies for cardiomyopathy.

28 Feb 2024

Study Highlights Lifelong Influence of Genetic Factors on Blood Pressure

Certain genes associated with hypertension affect blood pressure from early in life, and they increase the risk of cardiovascular disease as you get older. But you can do something about it.

26 Feb 2024

Researchers Unveil New Mechanism of Immune Cell Training in Thymus Gland

Immune cells must learn not to attack the body itself. A team of researchers from the Technical University of Munich (TUM) and the Ludwig Maximilian University of Munich (LMU) has discovered a previously unknown mechanism behind this: other immune cells, the B cells, contribute to the "training" of the T cells in the thymus gland.

22 Feb 2024