Pathology News and Research

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Pathology is the study and diagnosis of disease through examination of organs, tissues, bodily fluids, and whole bodies (autopsies). The term also encompasses the related scientific study of disease processes, called General pathology. Medical pathology is divided in two main branches, Anatomical pathology and Clinical pathology. Veterinary pathology is concerned with animal disease whereas Phytopathology is the study of plant diseases.

New Biomarker Offers Early Detection of ALS and FTD

Two progressively degenerative diseases, amyotrophic lateral sclerosis (ALS, commonly known as Lou Gehrig's disease) and frontotemporal dementia (FTD, recently in the news with the diagnoses of actor Bruce Willis and talk show host Wendy Williams), are linked by more than the fact that they both damage nerve cells critical to normal functioning -; the former affecting nerves in the brain and spinal cord leading to loss of movement, the latter eroding the brain regions controlling personality, behavior and language.

19 Mar 2024

SIRPβ1 Gene Mutation Alters Alzheimer's Disease Progression

The scientist of the Faculty of Medicine of the University of Malaga José Luis Royo has coordinated a study that summarizes eight years of research and brings together 100 multidisciplinary specialists, identifying a mutation that alters Alzheimer's disease progression.

18 Mar 2024

Metabolic Insights into Immune Cell Activation and Response

Researchers from Children's Hospital of Philadelphia identified a key metabolite in cells that helps direct immune responses and explains at a single cell level why immune cells that most efficiently recognize pathogens, vaccines, or diseased cells grow and divide faster than other cells.

18 Mar 2024

First Whole Genome Sequencing of Male Breast Cancer Reveals Potential Treatment Targets

Male breast cancer has distinct alterations in the tumor genome that may suggest potential treatment targets, according to a study by Weill Cornell Medicine investigators.

5 Mar 2024

Study Provides Insights Into Molecular Mechanisms Underlying Healthy Aging in Drosophila

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 3, entitled, "The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut."

28 Feb 2024

Scientists Develop First Full Model of Early Human Central Nervous System with Stem Cells

The first stem cell culture method that produces a full model of the early stages of the human central nervous system has been developed by a team of engineers and biologists at the University of Michigan, the Weizmann Institute of Science, and the University of Pennsylvania.

27 Feb 2024

Induction Cooktop Technology Shows Promise in Reducing Bacterial Infection in Prosthetic Joints

The same technology at work in induction cooktops cut the amount of bacteria present in a prosthetic joint infection when used in conjunction with antibiotics in a mouse model, UT Southwestern Medical Center researchers report in a new study.

19 Feb 2024

Study Suggests a Link Between DNA Methylation Disorder and Epigenetic Clocks

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 2, entitled, "Epigenetic drift underlies epigenetic clock signals, but displays distinct responses to lifespan interventions, development, and cellular dedifferentiation."

7 Feb 2024

RNA-Seq Unveils Molecular Subtypes for Tailored Pediatric B-ALL Treatment

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer, representing more than 30% of all pediatric cases.

31 Jan 2024

Bio-Techne’s Advanced Cell Diagnostics (ACD) Sets New Standard in Spatial Biology with Protease-Free RNAscope Multiomics

Bio-Techne Corporation today announced that Advanced Cell Diagnostics (ACD), a Bio-Techne spatial biology brand, has set a new standard with the development of a next-generation, protease-free RNAscope spatial multiomics workflow.

From Bio-Techne 30 Jan 2024

Promoter Mutations and Their Association with Autism Risk

The RIKEN Center for Brain Science (CBS) employed genome mutation analysis to investigate the genetics of autism spectrum disorder (ASD) in people and their families. They found that the way a certain type of genetic mutation contributes to the illness differs from that of ordinary mutations.

29 Jan 2024

Lunaphore and Acd Revolutionize Spatial Biology Research With the Launch of the First Fully Automated, Same-Section, Hyperplex Multiomics Application

Bio-Techne Corporation (NASDAQ: TECH) today announced that its spatial biology brands, Lunaphore and Advanced Cell Diagnostics (ACD), will launch the first fully automated spatial multiomics workflow with same-section hyperplex detection of RNA and protein biomarkers.

From Bio-Techne 25 Jan 2024

New Technology Enables Minimally-Invasive, High-Resolution Recording of Brain Activity

Sensors built with a new manufacturing approach are capable of recording activity deep within the brain from large populations of individual neurons–with a resolution of as few as one or two neurons–in humans as well as a range of animal models, according to a study published in the Jan. 17, 2024 issue of the journal Nature Communications.

18 Jan 2024

‘Mini-Placentas’ Help Scientists Study the Causes of Pre-eclampsia and Pregnancy Disorders

Scientists have grown ‘mini-placentas’ in the lab and used them to see how the placenta develops and interacts with the inner lining of the womb – findings that could help scientists better understand and, in future, potentially treat pre-eclampsia.

17 Jan 2024

Exploring the Dual Role of Phosphorylated α-Synuclein in Healthy Neural Function

It has been found by researchers that phosphorylated α-synuclein, a protein linked to a number of neurodegenerative illnesses, including Parkinson's disease and Lewy body dementia, is also engaged in the regular processes of neuronal communication in a healthy brain.

10 Jan 2024

Genetic Twist in Tiny Protein Protects Against Parkinson's

A previously unidentified genetic mutation in a small protein provides significant protection against Parkinson's disease and offers a new direction for exploring potential treatments, according to a new USC Leonard Davis School of Gerontology study.

3 Jan 2024

AI Tool Offers a Deep Dive Into Tissues, Boosting Cancer Detection and Treatment

A new artificial intelligence tool that interprets medical images with unprecedented clarity does so in a way that could allow time-strapped clinicians to dedicate their attention to critical aspects of disease diagnosis and image interpretation.

3 Jan 2024

Plants Use Stealth Molecular Weapon to Attack Cells of Invading Gray Mold

UC Riverside scientists have discovered a stealth molecular weapon that plants use to attack the cells of invading gray mold.

22 Dec 2023

Sirtuin 6 Boosts DNA Repair in Aging Cartilage Cells

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Sirtuin 6 activation rescues the age-related decline in DNA damage repair in primary human chondrocytes."

20 Dec 2023

Structural Insights Unmask Novel Adaptations and Functions of Human LINE-1 ORF2

Martin Taylor, MD, PhD, a physician investigator in the Department of Pathology at Massachusetts General Hospital and an instructor in Pathology at Harvard Medical School, is the lead corresponding author of a new study in Nature, Structural Analysis and Inhibition of Human LINE-1 ORF2 Protein Reveals Novel Adaptations and Functions.