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Breakthrough 3D Vascular Sheet Mimics Atherosclerosis for High-Throughput Drug Screening

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials.

16 Jan 2024

Novel Amino Acid Nanoparticles Offer Hope for Fighting Multi-Drug Resistant Cancers

Amino acids, such as tyrosine and tryptophan, are the fundamental building blocks that make up proteins.

9 Jan 2024

Genetic Twist in Tiny Protein Protects Against Parkinson's

A previously unidentified genetic mutation in a small protein provides significant protection against Parkinson's disease and offers a new direction for exploring potential treatments, according to a new USC Leonard Davis School of Gerontology study.

3 Jan 2024

Breakthrough in Synthetic Biology: Researchers Build Artificial CO2-Fixing Pathway

Synthetic biology offers the opportunity to build biochemical pathways for the capture and conversion of carbon dioxide (CO2).

3 Jan 2024

A Dihydrofolate Reductase Single-Domain Protein Catenane

Professor Wen-Bin Zhang of the College of Chemistry and Molecular Engineering at Peking University and the Beijing Academy of Artificial Intelligence, along with Dr. Jing Fang of the same institution, are leading the study.

2 Jan 2024

Novel Zebrafish Model Offers Efficient Tool for Norovirus Research

Food virologists from the National University of Singapore (NUS) have successfully propagated the human norovirus using zebrafish embryos, providing a valuable platform to assess the effectiveness of virus inactivation for the water treatment and food industries.

2 Jan 2024

AI-Powered Drug Breakthrough: Insilico Unveils Potent FGFR2/3 Inhibitor for Solid Tumors

Insilico Medicine, a generative artificial intelligence (AI)-driven clinical-stage drug discovery company, today announced the nomination of ISM8001, a novel molecule targeting FGFR2/3 for the treatment of tissue-agnostic solid tumors bringing the total number of PCCs nominated in 2023 to six.

29 Dec 2023

Zebrafish Embryo Model Unveils Breakthrough Cultivation Method

Researchers at the National University of Singapore (NUS) specializing in food virology have achieved successful cultivation of the human norovirus using zebrafish embryos.

29 Dec 2023

Xeno-Free Monkey PSC Culture System Enables Deriving, Tracking, and Differentiating Stem Cells

Non-human primates (NHPs) have a high degree of similarity to humans compared to other animal models.

26 Dec 2023

Novel Technique for High-Resolution Spectral Analysis of the Eye Fundus

Many ocular diseases involve changes in the structure and function of different regions of the back of the eye, also known as the "eye fundus."

18 Dec 2023

Omicron's Cellular Senescence May Explain Cytokine Storms and Long-COVID

A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 23, entitled, "Uncovering a unique pathogenic mechanism of SARS-CoV-2 omicron variant: selective induction of cellular senescence."

18 Dec 2023

Exploring the Effects of Vascularization Strategies on Brain Organoids

Researchers at Waseda University led by Assistant Professor Kosuke Kataoka, have uncovered crucial insights into brain organoids' development.

18 Dec 2023

FluidForm Bio 3D Bioprints Human Cardiac Tissue for Drug Development Breakthrough

FluidForm Bio, a leader in developing life-like human tissue to treat disease, shares recent advancements in building human cardiac tissues using FRESH 3D bioprinting.

13 Dec 2023

Misfolded Proteins: How They Damage Neurons and Cause Neurodegeneration

Neurodegenerative diseases are characterized by the deposition of clumped proteins in the brain and progressive neuronal cell death.

5 Dec 2023

Unraveling the Molecular Basis of SIDT1 and SIDT2 in C. elegans

New work thoroughly characterizes the structural features of human SIDT1 and SIDT2, revealing their existence as dimers in vitro and their tendency to form dimers or higher-order oligomers in their natural environment.

23 Nov 2023

Brunel University London Secures Japanese Patent for Gene Therapy Vector Safety Test

Gene therapy is a rapidly growing area of medical science. But there is little in the way of safety testing the vectors used to deliver gene therapy.

23 Nov 2023

Novel Biosensors Uncover Brain Activity

Researchers have employed novel biosensors to uncover neuropeptide activity in the brain, introducing innovative tools for examining the release, function, and regulation of these vital signaling molecules in vivo.

17 Nov 2023

Cancer Stem Cells Induce Macrophage Senescence, Creating Conditions for Tumor Formation

Cancer stem cells cause the aging of macrophages in mice with healthy immune systems, creating conditions for the formation of tumors.

15 Nov 2023

Novel Bacterial Protein can Prolong Cell Longevity by Acting Directly on Mitochondria

Researchers at the University of São Paulo (USP) in Brazil, partnering with colleagues in Australia, have identified a novel bacterial protein that can keep human cells healthy even when the cells have a heavy bacterial burden.

10 Nov 2023

Researchers Develop Novel Antifungal Drug with Potential to Save Lives

Scientists at the University of Illinois Urbana-Champaign, in collaboration with researchers at the University of Wisconsin-Madison, have developed a novel antifungal molecule.

9 Nov 2023

in vitro News and Research

Breakthrough 3D Vascular Sheet Mimics Atherosclerosis for High-Throughput Drug Screening

Novel Amino Acid Nanoparticles Offer Hope for Fighting Multi-Drug Resistant Cancers

Genetic Twist in Tiny Protein Protects Against Parkinson's

Breakthrough in Synthetic Biology: Researchers Build Artificial CO2-Fixing Pathway

A Dihydrofolate Reductase Single-Domain Protein Catenane

Novel Zebrafish Model Offers Efficient Tool for Norovirus Research

AI-Powered Drug Breakthrough: Insilico Unveils Potent FGFR2/3 Inhibitor for Solid Tumors

Zebrafish Embryo Model Unveils Breakthrough Cultivation Method

Xeno-Free Monkey PSC Culture System Enables Deriving, Tracking, and Differentiating Stem Cells

Novel Technique for High-Resolution Spectral Analysis of the Eye Fundus

Omicron's Cellular Senescence May Explain Cytokine Storms and Long-COVID

Exploring the Effects of Vascularization Strategies on Brain Organoids

FluidForm Bio 3D Bioprints Human Cardiac Tissue for Drug Development Breakthrough

Misfolded Proteins: How They Damage Neurons and Cause Neurodegeneration

Unraveling the Molecular Basis of SIDT1 and SIDT2 in C. elegans

Brunel University London Secures Japanese Patent for Gene Therapy Vector Safety Test

Novel Biosensors Uncover Brain Activity

Cancer Stem Cells Induce Macrophage Senescence, Creating Conditions for Tumor Formation

Novel Bacterial Protein can Prolong Cell Longevity by Acting Directly on Mitochondria

Researchers Develop Novel Antifungal Drug with Potential to Save Lives

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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