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Spatial Organization of Chromosomes and the Role of DNA Tension

Two protein complexes are primarily responsible for chromosomal spatial organization in human cell nuclei. DNA tension has an unanticipated function in this. Together with Austrian colleagues, nanoscientist Cees Dekker and his PhD candidate Roman Barth of TU Delft’s Kavli Institute of Nanoscience published their detailed visualization in Nature on April 19th, 2023.

21 Apr 2023

Gene-Silencing Complexes Work Together to Render X Chromosomes Inactive

Two protein complexes are involved in the mysterious process of shutting off one X chromosome in female mammals, according to a new study from RIKEN. This result could aid in the understanding of how specific tumors in women develop.

21 Apr 2023

Changes in Gut Microbiomes of Astronauts May be Linked to Bone Loss

In space, the bone density of both the human astronauts and rodent variety decreases. Scientists published this study on April 19th, 2023, in the journal Cell Reports. It says that alterations to the gut microbiomes of space travelers may be linked to this bone loss.

21 Apr 2023

MIT Researchers Identify Brain Cells Most Susceptible to Neurodegeneration

Neurodegeneration, or the gradual loss of neuron function, is one of the key features of Alzheimer's disease.

20 Apr 2023

Scientists Discover Gene That Plays a Key Role in Determining the Risk for Vascular Diseases

University of School of Medicine researchers have identified a gene that plays a crucial role in determining our risk for heart attacks, deadly aneurysms, coronary artery disease and other dangerous vascular conditions.

19 Apr 2023

Augmenting Anatomical EM Images with Multiplexed Gene Expression Maps

Special reporter proteins created by a research team guided by the Technical University of Munich may now aid in molecular discovery.

19 Apr 2023

The Function of ANKLE1 in the Prevention of DNA Damage and Autoimmunity

The University of Hong Kong (HKU) School of Biological Sciences research team led by Dr. Gary Ying Wai Chan has uncovered the function of a unique enzyme called ANKLE1.

19 Apr 2023

Cedars-Sinai and Axiom Space of Houston Collaborate to Send Stem Cells to Space

Cedars-Sinai investigators, in collaboration with Axiom Space of Houston, are sending stem cells to space in early May to explore whether microgravity can make it easier and more efficient to produce large batches of stem cells.

18 Apr 2023

Genomics Surveillance of Wheat Blast Fungus may be an Effective Disease Management Tool

Pests and diseases may reduce global wheat yields by over 20%. A study published April 11th in the open access journal PLOS Biology by Sergio Latorre at University College London, UK and colleagues suggest that genomic surveillance may be an effective disease management tool with the ability to trace lineages of emerging crop diseases, and to identify genetic traits for breeding disease-resistant lines.

18 Apr 2023

Sickle Cell Disease Cure? Prime Editing Offers Hope for Blood Disorder

At St Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard, researchers have shown how prime editing could help correct the mutation that results in sickle cell disease in a possibly curative method.

18 Apr 2023

UH Researcher Designs New Model Expressing the Most Common Disease Mutation in USH2A

Usher syndrome, a rare inherited genetic disease, is a leading cause of combined deafness and blindness with type 2A (USH2A) being the most common form.

18 Apr 2023

Prime Target for Male Contraceptive Development Identified

As far as a highly effective, reversible, and non-hormonal male contraceptive for humans and animals is concerned, the discovery of a gene in multiple mammalian species could set the stage.

18 Apr 2023

New Embryonic Brain Circuit Offers New Insights on Circuit Abnormalities in Autism

Researchers have discovered an active multi-layer circuit that emerges in the cortex at an unexpectedly early stage of development using a new method for analyzing live embryonic mouse brains at single-cell resolution.

18 Apr 2023

New Method Uses Light to Activate Protein Functions

Scientists can now use light to activate protein functions both inside and outside of living cells. The new method, called light-activated SpyLigation, can turn on proteins that are normally off to allow researchers to study and control them in more detail.

18 Apr 2023

Leveraging Advanced Genomic Approaches for Amphibian Conservation

Morris Animal Foundation and Revive & Restore recently announced the funding of five new projects building genomic tools for amphibian conservation.

18 Apr 2023

Study Tracks How the Gut Microbiota Changes During First Three Months of Life

Details of how the gut microbiota changes during the first three months of life will be presented at this year's European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Copenhagen, Denmark (15-18 April).

17 Apr 2023

Genetic Changes Affecting Cartilage Cell Maturation may Influence Adult Height, Study Shows

When it comes to height, our fate is sealed along with our growth plates—cartilage near the ends of bones that hardens as a child develops.

17 Apr 2023

New Tool can Help Untangle Genetic Factors Associated with Shared Characteristics Among Different Species

Aston University has worked with international partners to develop a software package to help scientists answer key questions about genetic factors associated with shared characteristics among different species.

17 Apr 2023

Entry of Aging-Associated Enzymes into Human Genetic Material

An enzyme that controls aging and other metabolic processes accesses human genetic material to modify gene expression within the cell, according to a new study. Images of a sirtuin enzyme bound to a nucleosome, a tightly packed complex of DNA and proteins called histones, have been created by a team led by Penn State researchers.

17 Apr 2023

Identifying Lung Cancer Patients Who May Not Respond Well to Immunotherapy by MYC Gene Activation

Lung cancer patients who may not react well to immunotherapy (ICB) could be identified by the oncogenic activation of MYC, an important gene in the development of cancer.

17 Apr 2023

Genetic News and Research

Spatial Organization of Chromosomes and the Role of DNA Tension

Gene-Silencing Complexes Work Together to Render X Chromosomes Inactive

Changes in Gut Microbiomes of Astronauts May be Linked to Bone Loss

MIT Researchers Identify Brain Cells Most Susceptible to Neurodegeneration

Scientists Discover Gene That Plays a Key Role in Determining the Risk for Vascular Diseases

Augmenting Anatomical EM Images with Multiplexed Gene Expression Maps

The Function of ANKLE1 in the Prevention of DNA Damage and Autoimmunity

Cedars-Sinai and Axiom Space of Houston Collaborate to Send Stem Cells to Space

Genomics Surveillance of Wheat Blast Fungus may be an Effective Disease Management Tool

Sickle Cell Disease Cure? Prime Editing Offers Hope for Blood Disorder

UH Researcher Designs New Model Expressing the Most Common Disease Mutation in USH2A

Prime Target for Male Contraceptive Development Identified

New Embryonic Brain Circuit Offers New Insights on Circuit Abnormalities in Autism

New Method Uses Light to Activate Protein Functions

Leveraging Advanced Genomic Approaches for Amphibian Conservation

Study Tracks How the Gut Microbiota Changes During First Three Months of Life

Genetic Changes Affecting Cartilage Cell Maturation may Influence Adult Height, Study Shows

New Tool can Help Untangle Genetic Factors Associated with Shared Characteristics Among Different Species

Entry of Aging-Associated Enzymes into Human Genetic Material

Identifying Lung Cancer Patients Who May Not Respond Well to Immunotherapy by MYC Gene Activation

Genetics & Genomics - Second Edition eBook

Driving Support for Pharmaceutical Testing Through Continuous Innovation

From Memory to Metaplasticity: Unraveling the Brain's Secrets

Revolutionizing Mass Spectrometry: A Deep Dive into Plasmion’s SICRIT® Technology

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